University of Minnesota

Characterization of genetically effective cells and EMS mutagenesis on the novel winter oil seed Pennycress ( Thlaspi arvense )

Abstract We investigated the impact of Ethyl methanesulfonate (EMS) on genetically effective cells (GECs) to characterize the intra-individual genetic variation of EMS mutagenesis in the novel intermediate crop pennycress (Thlaspi arvense L.). We identified that pennycress contai...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Discovery of Energy‐Localized Trap States via Opto‐Electrical Spectroscopy in UWBG Perovskite La:SrSnO 3 FETs

ABSTRACT Strontium stannate perovskite (SrSnO 3 ) is emerging as a promising material for next‐generation ultra‐wide bandgap (UWBG) semiconductors due to its high electron mobility and optical transparency. However, despite the critical importance of defect analysis to utilize La...

Multi-stakeholder perspectives on acceptability and delivery of buprenorphine for women who use drugs

Women who use drugs (WWUD) face substantial barriers to accessing medications for opioid use disorder (MOUD), including buprenorphine. As part of a formative evaluation to co-design a community-based intervention for MOUD delivery, we explored multi-stakeholder perspectives on th...

eDNA-based assessment of microbial dynamics in response to persistent contaminants and degraded water quality in a hypereutrophic urban reservoir

Abstract Urban freshwater ecosystems are increasingly exposed to mixtures of pollutants, including per- and polyfluoroalkyl substances (PFAS). However, their ecological effects remain poorly understood, especially in tropical regions with limited sanitation infrastructure. This s...

A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.

serves as an exemplary commensal mycobiota model, revealing distinct mechanisms for host tolerance and immune modulation.

A Dynamic Auroral Ionospheric Density Profile Reveals a Planetary-Scale Cavity at Jupiter

Low-altitude measurements above Jupiter’s main auroras have shown the presence of persistent auroral density depletions. This low density regime strongly favors auroral acceleration by inertial Alfvén waves to explain the predominance of energetic (100–1000 keV) broadband electro...

Reversible Switching due to Attraction and Repulsion: Clusters, Gaps, Sorting, and Mixing

Abstract. We describe a phase transition in continuum limits of interacting particle systems that exhibits a vertical bifurcation diagram. The transition is mediated by a competition short-range repulsion and long-range attraction. As a consequence of the transition, infinitesima...

Evaluating Bayesian Variable Selection Approaches for Nonlinear Random Effects Models

Longitudinal data modeling attracts special interest from researchers and practitioners because of its capacity to help understand individual and mean trends of growth and development over time. One feature of longitudinal design is the collection of extensive information on part...

Efficacy and Safety of Time-Restricted Eating in Adults With Type 1 Diabetes: A Randomized Controlled Trial

OBJECTIVE: Many adults with type 1 diabetes (T1D) have overweight or obesity, underscoring the need for effective dietary weight loss strategies in this population. Time-restricted eating (TRE) has emerged as a popular approach for weight loss; however, its efficacy and safety in...

Changes in resting-state functional connectivity between large-scale brain networks after an intensive arts intervention for adolescents with depression

Emerging data support the benefits of creative arts interventions for addressing depression in adolescents, but the neural mechanisms are poorly understood. This study examined changes in connectivity among large-scale brain networks implicated in both depression and creativity,...

Airborne eddy covariance measurements of ocean-air VOC fluxes: Distinguishing signal from noise

Abstract. Ocean-atmosphere exchange plays an important but uncertain role for many volatile organic compounds (VOCs). Airborne eddy covariance (EC) enables direct flux quantification over large areas, but VOC applications have largely been performed over land. Here we combine the...

A Review ofAmmonia (NH3) Adsorption inPorous Solids

Abstract Ammonia (NH3) plays a crucial role in the agricultural sector as a fertilizer and is a dense hydrogen carrier that offers a potential renewable and carbon-free energy source. These significant advantages necessitate the development of efficient NH3 synthesis and separati...

Breaking voltage-controlled magnetic anisotropy–magnetoresistance trade-off for ultralow-energy switching in magnetic tunnel junctions

Electric-field control of spin states offers a promising route to ultralow-power, ultrafast magnetization switching in spintronic devices such as magnetic tunnel junctions (MTJs). However, enhancing voltage-controlled magnetic anisotropy (VCMA) through interfacial engineering oft...

Theta deep-brain stimulation improves cognitive performance in Parkinson’s patients with cognitive impairments

ABSTRACT Background Patients with Parkinson’s disease (PD) almost inevitably experience cognitive impairments. These deficits have been linked to low frequency “theta” cortical activity ∼4 Hz, previously associated with cognitive control. Objective Our study investigated effects...

Promotion of sensorimotor and attentional development for infants at elevated likelihood of autism: single case experimental design of novel caregiver implemented NDBI

Infants with familial autism are at elevated likelihood for future neurodevelopmental needs, including autism spectrum disorder, attention deficit hyperactivity disorder, and clinically significant cognitive and behavioral challenges. Science is advancing the near-future ability...

Electron Transferto Colloidal ZnO Nanocrystals fromthe Excited State of a Perylene Chromophore Formed by Direct Excitationor Triplet–Triplet Annihilation Upconversion

Abstract Upon binding 4-(perylen-3-yl)benzoic acid 1, to oleate-capped ZnO nanocrystals (NCs), significant broadening of the perylene absorption spectrum and fluorescence quenching were observed. In contrast, no broadening of the absorption spectrum or fluorescence quenching was...

Haplotype phasing of de novo chromosome-level assembly of ‘Antonovka’ facilitated the identification of candidate genes for apple scab resistance

Malus genomic resources with improved quality are becoming an integral part of candidate gene identification and functional validation. Recently, we released a reference-based phased chromosome-level genome assembly of ‘Antonovka’ 172670B Malus domestica cultivar from the ‘Antono...

Tackling anti-tumor macrophage function through genome engineering

In the realm of cellular immunotherapies, the synthetic chimeric antigen receptor (CAR) has proven to be a revolutionary modality, leading to the US Food and Drug Administration approval of multiple autologous CAR T cell products. Despite their remarkable success in hematological...

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date

Breakdown of the blood–retinal barrier (BRB) is implicated in many blinding retinal diseases, including diabetic macular edema, neovascular age-related macular degeneration, and retinal vein occlusion. Anti-vascular endothelial growth factor (anti-VEGF) therapies or laser photoco...