University of Minnesota

Structure-Based Insights into the Molecular Mechanisms of LuxR-Type Quorum Sensing Receptors

Quorum sensing (QS) enables bacteria to coordinate collective behaviors in response to population density. LuxI/R QS systems, common among gram-negative bacteria, consist of a LuxI-type synthase that produces an N- acyl L -homoserine lactone (AHL) signaling molecule and a LuxR-ty...

Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy

Abstract A bidirectional relationship has been proposed between sleep and Alzheimer’s disease pathology, such that disruption to sleep can lead to increases in the expression of tau or its phosphorylation. Over the long term, this can potentially lead to greater expression of neu...

Plasma wave observations from Juno spacecraft at the Jovian bow shock

Recent observations of Jupiter’s bow shock have provided new insights into the energy dissipation mechanisms associated with bow shocks of outer planets. At greater distances from the Sun, the typically increasing super-Alfvénic nature of the solar wind leads to higher-energy bow...

Discontools supplement Mycoplasma hyopneumoniae infections in pigs: update and knowledge gaps

This manuscript reviews current knowledge on Mycoplasma hyopneumoniae , the primary agent of enzootic pneumonia in pigs, integrating advances in epidemiology, pathogenesis, immunity, diagnostics, and control. The pathogen is globally endemic, with transmission driven mainly by di...