University of Michigan

Platelet Reactivity and Sex Differences: Clinical Implications for Women

Platelets are central to hemostasis and thrombosis. Excessive platelet activation contributes to arterial thrombotic events, including myocardial infarction, ischemic stroke, and complications of peripheral artery disease, whereas excessive platelet inhibition increases bleeding...

Quantitative computed tomography improves prediction of survival across ILD subtypes

Background Quantitative computed tomography (CT) methods are recognized as valuable tools for risk stratification in fibrotic interstitial lung disease (ILD). Data-driven textural analysis (DTA) is one such approach that correlates with worse lung function and shorter survival in...

Stereoselectivity inLiquid Aerosols through Acid-MediatedEpoxide Ring-Opening Reactions

Abstract Stereoisomers in aqueous atmospheric aerosols are assumed to be present in equal concentrations, as aerosols are most commonly mixtures of simple inorganic salts with a range of organic species that lack obvious pathways to induce stereoselectivity. Further, since submic...

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date

Breakdown of the blood–retinal barrier (BRB) is implicated in many blinding retinal diseases, including diabetic macular edema, neovascular age-related macular degeneration, and retinal vein occlusion. Anti-vascular endothelial growth factor (anti-VEGF) therapies or laser photoco...

Co-Encapsulation of Indocyanine Green J-Aggregate and Paclitaxel in Biodegradable Polymersomes for Photoacoustic-Guided Chemotherapy

Abstract Treatment of solid tumors remains one of the biggest challenges in oncology. Targeted nanotherapeutics could significantly improve treatment efficacy and reduce side effects. However, their efficient implementation requires knowledge of pharmacokinetics (PK) and biodistr...

Searching the Literature by Meaning: Benchmarking Free and Commercial Word Embedding Models on Social Work Text

<p><b><i><span>Purpose</span></i></b><span>: Locating relevant studies is the first step of evidence-based practice, yet most searching relies on keyword matching. Artificial intelligence (AI) tools called embedding models search by...

Configuring the Geography of Social Service Provision: Neighborhood Characteristics, Nonprofit Spatial Strategies, and Public Funding

Social services in the United States are delivered jointly by government and nonprofits. Prior research examines either the location or the resources of nonprofits; it rarely examines how these factors jointly influence social service availability or access. We leverage a unique...

suPAR Identifies Treatment-Resistant Inflammatory Risk Beyond hs-CRP in Type 2 Diabetes With Coronary Artery Disease: An Ancillary Analysis of BARI 2D

OBJECTIVE To determine whether soluble urokinase plasminogen activator receptor (suPAR) is modified by randomized diabetes and revascularization strategies in patients with type 2 diabetes and coronary artery disease and whether combined suPAR and hs-CRP classification refines re...

Variation in Thyroidectomy Use in Low-Risk Thyroid Cancer: Analysis of a Statewide Claims Registry

Introduction Studies have shown variation in thyroidectomy use across geographic settings but have not examined statewide, procedure-specific (total thyroidectomy [TT] versus thyroid lobectomy [TL]) rates for thyroid cancer at the surgeon or facility level. This study aimed to ch...

Size-DependentChemical Speciation in CementitiousQuarry Waste

Abstract Quarry waste, especially adjacent to cementitious rock formations, presents an underutilized mineral resource given that geo-processes generate gradients in composition across vast scales. We inferred, and demonstrate, that mechanical breakdown depends on chemical compos...

Bank Systems

We are introducing the Axiomatization Framework of Bank Systems. Some theorems are completed about Housing, and other Assets Management.

Traumatic Catheter Removal‐ At‐Risk Populations, Outcomes and Prevention: A Retrospective Medical Record Review

AIMS: Traumatic catheter removal (TCR) occurs when a urinary catheter is removed with the balloon inflated, causing urethral injury. We aim to identify cases of TCR, determine at-risk populations and describe outcomes and interventions. DESIGN: Retrospective medical record review...

Bank Systems

We are introducing the Axiomatization Framework of Bank Systems. Some theorems are completed about Housing, and other Assets Management.

Rural-Urban Disparities in Contemporary Systemic Therapy for Advanced Prostate Cancer

This cross-sectional study examines the associations of rural-urban residence and race with receipt of systemic therapy for advanced prostate cancer.

Going Green online: how higher education institutions use Instagram to communicate sustainability

As institutions of higher education increasingly seek to differentiate themselves through sustainability initiatives, social media platforms such as Instagram offer a powerful channel to reinforce these commitments. This study explores the differences in sustainability-related me...

Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy

Gut microbial metabolites play crucial roles in regulating systemic immunity, but their mechanisms and limited drug-like properties remain unresolved. Here we report an oral nano-formulation that leverages gut microbial metabolites to modulate T cell metabolism and amplify antitu...

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Exploring Social Determinants of Cognitive Functioning: History of Criminal Legal System Involvement and Processing Speed Among Older Black Americans

Cognitive impairment disproportionately impacts Black Americans in later life. Black Americans are also disproportionately in contact with the criminal legal system (CLS; e.g., arrest, incarceration). Emerging research indicates that CLS involvement has negative implications for...

Modular Electrochemical Sensing via In Situ Reduced Carbon Quantum Dot–Nanotube Molecular Hybrids

Abstract Electrochemical sensing is a promising route to non-invasive, point-of-care health monitoring, yet practical multiplexing remains limited by electrode materials that cannot simultaneously deliver high conductivity, high densities of electrochemically active sites, and mo...

Exploring the protective role of school peers in substance use prevention among American Indian adolescents

Social network scholars have long recognized the role that social connections play in the substance use behavior of adolescents as they rely less on their parents/caregivers and more on their school peers. In this article, we explore the role of social networks as they relate to...