University of Michigan

Insulin-Regulated Actin Dynamics is Disrupted in a Human Keratinocyte Model of Hailey Hailey Disease

Abstract Hailey Hailey Disease (HHD) is an autosomal dominant cutaneous disorder caused by mutations in ATP2C1 , the gene encoding the Golgi/secretory pathway Ca 2+ -ATPase SPCA1. Characterized by suprabasal acantholysis and intertriginous blistering of the skin, HHD treatment fo...

Smart Lithotripsy: Lasers, Energy Sources and Efficiency

PURPOSE OF REVIEW: To examine the evidence on contemporary lasers and provide a practical framework for platform selection, parameter optimization, and thermal safety based on the principles of smart lithotripsy. RECENT FINDINGS: Holmium: yttrium-aluminum-garnet (Ho:YAG) remains...

Noise protected logical qubit in an open chain of superconducting qubits with ultrastrong interactions

To achieve a fault-tolerant quantum computer, it is crucial to increase the coherence time of quantum bits. In this work, we theoretically investigate a system consisting of a series of superconducting qubits that alternate between XX and YY ultrastrong interactions. By consideri...

Game Developments [Simulation and Convergence Scenarios]

There are tools to fastly simulate the Universe in Diverse Scenarios : among those tools, are mainly the Game Development tools. We will introduce few notes about them.

Persistence in GLP-1–Based Therapy Among Adults with Obesity and Type 2 Diabetes: A Narrative Review of Definitions, Real-World Outcomes, and Determinants

Abstract Purpose of Review Persistence with glucagon-like peptide-1 (GLP-1)–based therapies is important for sustained weight loss and glycemic control in adults with coexisting obesity and type 2 diabetes. This narrative review examined how persistence has been defined and measu...

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Who’s a “Good” Victim of Gender-Based Violence?: Credibility, Worthiness, and Ideal Victimhood in Victim Compensation Law

Abstract Scholars have argued that institutions privilege “good” victims of gender-based violence – those deemed sympathetic, morally upstanding, and worthy of public support. We extend existing research by synthesizing theories of good victimhood and theoretically distinguishing...

Racial and Ethnic Differences in Classic and 11-Oxygenated Androgens in Men

BACKGROUND: Androgen-dependent prostate pathology, including prostate cancer and benign prostatic hyperplasia, differs in prevalence and phenotype across races/ethnicities. Adrenal-derived 11-oxygenated C19 steroids (11-oxyandrogens) are relevant to several androgen-dependent pat...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Gender disparities among general surgery residents’ ACGME case logs develop over the course of training

Abstract Background Gender disparities in operative autonomy and case volume persist in general surgery residency training. Compared to their male counterparts, female trainees graduate with lower ACGME case log totals and perceive lower intraoperative autonomy. While prior studi...

Interpreter Use and Challenges in Primary Care

This survey study investigates use of interpreters and challenges experienced by physicians treating patients with limited English proficiency.

Properties of Multidimensional Vector Zeckendorf Representations

A generalization of Zeckendorf’s theorem states for integer k≥3, every nonnegative integer has a unique k-Zeckendorf representation as a sum of distinct k-bonacci numbers, where no k consecutive k-bonacci numbers are present in the representation. Anderson and Bicknell Johnson ex...

Psychological and Educational Outcomes of Chinese Rural Migrant Youths in Urban Schools: A Person-Centered Examination of Cross-Time Transitions

Abstract This study adopts a person-centered approach to examine how profiles of relationships with parents, teacher recognition, and peer relationships conjoin and influence the academic and psychological wellbeing of Chinese migrant adolescents. Drawing upon two-wave data from...

A permeable protein nanocage enables facile cargo loading and cytosolic protein delivery

Abstract The cytosolic delivery of therapeutic proteins remains one of the most persistent challenges in modern drug delivery. Here, we report the discovery and characterization of an encapsulin-based protein nanocage, QtEnc, with unexpected permeability properties and the abilit...

Recurrent Deliberate Foreign Body Ingestion: Psychiatric Comorbidities, Management Strategies, and Ethical Considerations

PURPOSE OF REVIEW: Recurrent deliberate foreign body ingestion (DFBI) is a high-risk, resource-intensive behavior most often associated with underlying psychiatric conditions. Although medical and surgical complications are well documented, the psychiatric drivers and optimal man...

Neuropathy With Demyelinating Features in a Patient With Biallelic HARS1 Variants

ABSTRACT Background and Aims The HARS1 gene encodes cytoplasmic histidyl‐tRNA synthetase, which catalyzes the ligation of histidine to tRNA HIS in the cytoplasm as an early step in protein biosynthesis and is essential for cell viability. Pathogenic variants in HARS1 have been as...

Genomic catalogue of giant viruses reveals expanded diversity and functional potential

Nucleocytoplasmic large DNA and Mirusviricota viruses exhibit taxonomic richness which continually expands due to metagenomic sequencing. Here we curate a database of giant virus metagenome-assembled genomes (GVMAGs V2), comprising 8,508 species-level representatives from 18,727...

Affidavit of Support [SponsorShip Path]

We are grateful for the Opportunity to apply to Biola University. The platform is requesting an affidavit of Support. In the Internet Guidelines, Some Institutions can offer Affidavit of Support as SponsorShip Investments.

LncPNdeep: A long non-coding RNA classifier based on large language model with peptide and nucleotide embedding

Abstract Long non-coding RNA plays an important role in various gene transcription and peptide interactions. Classifying lncRNAs from coding RNA is a crucial step in bioinformatics analysis which seriously affects the post-analysis for transcriptome annotation. Although several m...

Controls on Solar Wind Entry Identified Through Wind–ACE Heavy‐Ion Diagnostics

Abstract Solar wind (SW) entry into the magnetosphere occurs through several mechanisms, but their dependence on the properties of different ion species is unknown. We compare measurements from Wind‐STICS (magnetosphere) with ACE‐SWICS (L1) to test for any preferential entry betw...