University of Manchester

Shear‐Thinning Rheology Reshapes Hydrodynamic Dispersion in Heterogeneous Fractures

Abstract Hydrodynamic dispersion of shear‐thinning fluid in fractured rocks is jointly governed by fracture heterogeneity and fluid rheology, yet the way aperture correlation length alters dispersion mechanisms remains unclear. Here, we carry out pore‐scale lattice Boltzmann simu...

Social mobility and long-term episodic memory in Britain

ABSTRACT Population ageing increases the importance of cognitive capacity for making decisions about retirement and living independently beyond it. We tested whether post-war educational expansion and working-life social mobility eliminate the association between social class of...

Prion-like transmission of human tau strains in the mouse brain

Abstract Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding 1 . Distinct conformations of amyloid filaments may provide the physical basis for the strains th...

Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial

Abstract Werner syndrome helicase (WRN) is a synthetic lethal target for microsatellite instability (MSI) cancers. In part 1 of this ongoing first-in-human, phase 1 trial, escalating doses of RO7589831 (VVD-133214), a first-in-class, WRN covalent inhibitor, were evaluated in 88 p...

Satellite-based global monitoring of urban-scale methane emissions

Quantifying and understanding methane emissions of cities are of great importance given their role in current and future mitigation efforts to reduce climate-forcing emissions. However, it remains challenging to routinely and accurately characterize and verify city-scale methane...

Bayesian power spectrum estimation with modelling of systematic effects in delay-fringe rate space

Abstract Observing the Epoch of Reionisation using 21cm radio interferometry has proven to be a challenging task. Extraction of the extremely faint redshifted signal is complicated by the presence of bright foregrounds, radio frequency interference (RFI), and systematic artefacts...

Race as a status marker in contemporary international society: The case of the ‘Japan Threat’ thesis

Abstract This article advances the debate on race and hierarchy in international politics. It explores the continued salience of racial hierarchies in maintaining or elevating a state’s status within the international system and examines how ‘racial social fields’ operate in the...

A multidisciplinary perspective on digital health interventions in schizophrenia care: Expanding the 2026 Grading of Recommendations, Assessment, Development and Evaluations guidelines

In this paper, we aim to provide a multidisciplinary and lived-experience-informed perspective on existing evidence for the utilisation of digital health interventions in schizophrenia care. We have integrated the findings from the most recent meta-analysis of digital health inte...

The effects of increasing and decreasing dopamine on inhibition of return: a psychopharmacological investigation

Abstract Inhibition of Return (IOR) is the phenomenon of being slower to re-attend to previously attended locations, and is thought to improve the efficiency of attention. Previous studies of dopaminergic disorders indicate that excessive or insufficient dopamine signaling in the...

A 4′‐Thioribouridine Modification Mimics 2′‐ O ‐Methoxyethyl in ASO‐Like 20‐Mers Targeting PTEN Knockdown

Gapmer antisense oligonucleotides (ASOs) represent a clinically validated therapeutic platform, with a 2′‐ O ‐methoxyethyl modification commonplace within the flanking regions. An alternative sugar modification, incorporation of 4′‐thioribose, has demonstrated enhanced nuclease r...

In vitro evaluation of pH, calcium ion release and interfacial characterization of calcium silicate–based and epoxy resin–based sealers

Abstract This in vitro study evaluated the physicochemical properties and interfacial behavior of four calcium silicate–based sealers (CSBS) compared to an epoxy resin–based sealer. Specimens were prepared under standardized conditions, and pH and calcium (Ca 2+ ) ion release wer...

Conserved circadian membrane rhythms arise from divergent cellular mechanisms in pacemaker neurons of mice and Drosophila

Abstract Circadian clocks align physiology and behaviour with daily environmental cycles, requiring neuronal networks that encode and transmit time-of-day information. Whether conserved electrophysiological principles underlie circadian output across evolution remains unclear. We...

Deception in care giving: legal and ethical complexities in the administration of covert medication

Covert medication (CM) - the surreptitious administration of drugs in food or drink is often framed as a ‘moral gamble’ and remains a pervasive yet controversial necessity in the care of older people with cognitive impairments. As global populations age and neurodegenerative cond...

The Gravitational-wave Optical Transient Observer (GOTO) Fast Analysis and Spectroscopy of Transients (FAST) Surveys

Abstract The study of young and fast astronomical transients is often limited by the difficulty of acquiring data, particularly spectra, within hours to days of explosion. Historically, follow-up programmes have rarely obtained spectra until many days after discovery; coupled wit...

A New Species of Box Jellyfish (Cnidaria: Tripedaliidae: Tripedalia) from Hong Kong, China

sp. nov. as a distinct species. This new species represents the fourth described species of Tripedaliidae, and the first record of the family in Chinese coastal waters.

Procurement as an Innovation Lever for Big Science: Mechanisms, Measurement, and an Agenda for Change

Abstract Public procurement is one of the most direct and traceable channels through which Big Science investments generate wider socio-economic benefit, yet it remains significantly underexploited as an innovation lever. Drawing on the public procurement of innovation (PPI) lite...

Combined crystal plasticity–phase field fracture simulation to understanding particle cracking in recycled 6xxx aluminium alloy

Increasing the use of recycled aluminium alloys in wrought applications requires increasing tolerance to impurities such as iron. These impurities form brittle constituent particles that can crack or de-bond, leading to a reduction in formability. The fraction, size, shape, and d...

Land transformation driven by wind and solar development in Brazilian municipalities

Abstract In the last decade, Brazil’s energy sector has been moved from an exclusively hydroelectric and thermal mix to incorporate large-scale production of wind and solar photovoltaic energy. This energy transition is synchronized with the global imperative to reduce greenhouse...

Revisiting fully residually free Demushkin groups

Abstract We establish new examples and non-examples of pro- $$p$$ p limit groups among the class of Demushkin groups, that is, pro- $$p$$ p Poincaré duality groups of dimension $$2$$ 2 .

Conjugate heat transfer and melting mechanisms of a metallic phase change capsule with an internal cavity under external forced convection

Conjugate heat transfer during charging of encapsulated metallic phase-change materials (PCMs) is controlled by external convection, shell conduction and transport within the melt. Previous studies commonly prescribe uniform shell temperatures or neglect the influence of internal...