University of Manchester

Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications

PURPOSE OF REVIEW: This review examines the mechanistic, epidemiological and therapeutic evidence underpinning liver integration into the cardiovascular-kidney-metabolic (CKM) construct. For the purposes of this review, we use the term cardiovascular-renal-hepatic-metabolic (CRHM...

Elementary characterization of the Galois groups of x 12 + ax 6 + b

Abstract Let f ( x ) = x 12 + a x 6 + b ∈ Q [ x ] $f\left(x\right)={x}^{12}+a{x}^{6}+b\in \mathbb{Q}\left[x\right]$ be an irreducible polynomial, g 4 ( x ) = x 4 + ax 2 + b , g 6 ( x ) = x 6 + ax 3 + b , and let G 4 and G 6 be the Galois groups of g 4 ( x ) and g 6 ( x ), respect...

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

BACKGROUND: Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and atte...

Psychological interventions for individuals affected by Huntington’s disease: effects on depression, anxiety, and emotional well-being

Abstract Introduction The literature provides limited evidence on the effectiveness of psychological interventions for individuals living with Huntington’s Disease (HD). This study aims to examine the role of psychological support in improving the well-being of individuals and fa...

Coordinated control of heterogeneous grid-connected energy storage systems

In this paper, it is demonstrated how the coordinated control of heterogeneous grid-connected Energy Storage Systems (ESSs) can result in increased profits compared to operating the ESSs independently when participating in the UK frequency market. A heterogeneous set of ESSs is m...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Attendance Among People With Hepatitis B in UK Secondary Care: A Scoping Review.

Chronic Hepatitis B disease requires lifelong monitoring to prevent complications such as cirrhosis and hepatocellular carcinoma. Despite structured care pathways, non-attendance within UK secondary care remains challenging. This scoping review aimed to synthesise existing eviden...

Scaling Up Molecular Electron Spin Qubits Around a Core‐Shell Quantum Dot

ABSTRACT Attachment of molecular nanomagnets (MNMs) to surfaces is an essential step toward multi‐qubit assemblies for the implementation of quantum information technologies. Here, thiol‐monofunctionalized {Cr 7 Ni} molecular antiferromagnetic rings that have potential as electro...

Preoperative Factors Associated with Weight Loss and Recurrent Weight Gain after Bariatric Surgery: A Longitudinal Study in a UK Public Healthcare Setting

OBJECTIVE: Bariatric surgery is an effective treatment for obesity. This study aims to identify demographic factors of weight loss and recurrent weight gain over a 10-year follow-up period. METHODS: This retrospective observational study includes 2092 patients for overall trends,...

Comparison of Methods for Incorporating Related Data When Developing Clinical Prediction Models: A Simulation Study

Clinical Prediction Models (CPMs) compute an individual's risk of an outcome, given a set of predictors. Guidance states CPMs should be constructed using data sampled from the target population. However, researchers might have access to ancillary data sets from different time poi...

Semi-pessimistic Reinforcement Learning

Offline reinforcement learning aims to learn an optimal policy from pre-collected data. However, it faces challenges of distributional shift, where the learned policy may encounter unseen scenarios not covered in the offline data. Additionally, numerous applications suffer from a...

A RAC1 SUMOylation switch governs breast cancer metastasis

Despite the major advances in breast cancer management over the past few decades, metastatic breast cancer continues to be a major concern and the main cause of mortality associated with this disease. The Rho GTPase RAC1 has been implicated in breast cancer aggressiveness, yet th...

Lost in translation: understanding of jargon used in clinic-patient correspondence

To establish the level of older adults’ understanding of medical jargon used in letters sent to patients from audiology departments after an audiology assessment appointment. Participants were asked to define commonly used audiology jargon terms via an online survey platform. The...

Axial dysprosium cyclopentadienyl-amide single-molecule magnets with hysteresis up to 92 kelvin

Abstract Molecules showing magnetic memory effects at high temperatures could be used in high-density data storage devices. A magnetic hysteresis temperature ( T H ) of 100 K has been achieved for a near-linear dysprosium bis(amide)-alkene single-molecule magnet (SMM), and a bent...

SurgAnt-ViVQA: learning to anticipate surgical events through GRU-driven temporal cross-attention

Abstract Purpose Anticipating forthcoming surgical events is vital for real-time assistance in endonasal transsphenoidal pituitary surgery, where visibility is limited and workflow changes rapidly. Most visual question answering (VQA) systems reason on isolated frames with static...

A qualitative exploration of researchers’ efforts to record healthcare encounters

Recordings of healthcare encounters are a rich source of data, providing high-quality evidence to guide improvement in communication. Through a survey, we explored UK researchers’ experience of attempting to employ this method. Findings highlight challenges throughout the researc...

The distribution of the ratio of products of independent zero mean normal random variables

Abstract Let $$X_1,\ldots ,X_M$$ X 1 , … , X M and $$Y_1,\ldots ,Y_N$$ Y 1 , … , Y N be independent zero mean normal random variables with variances $$\sigma _{X_i}^2$$ σ X i 2 , $$i=1,\ldots ,M$$ i = 1 , … , M , and $$\sigma _{Y_j}^2$$ σ Y j 2 , $$j=1,\ldots ,N$$ j = 1 , … , N ,...

Has the situation changed? Spatio-temporal analysis of green spaces change and socioeconomic status in Liverpool, UK

Although the benefits of green space to residents’ wellbeing are well documented, more evidence is needed to track socio-spatial inequalities. This paper applied exploratory spatial data analysis and multiscale geographically weighted regression (MGWR) to analyse the relationship...

Efficacy of mRNA-based HPV Vaccines in Inducing Immune Response and Preventing Oncogenic Outcomes: A systematic review and meta-analysis

Background Human papillomavirus (HPV) infection represents a substantial global health burden, being the primary etiological agent of cervical cancer, anogenital and oropharyngeal malignancies. Although prophylactic virus-like particle (VLP) vaccines have been successfully implem...

The diagnosis and management of primary mediastinal B‐cell lymphoma: A British Society for Haematology guideline

Summary Primary mediastinal B‐cell lymphoma (PMBCL) is a distinct clinicopathological entity within the spectrum of aggressive B‐cell lymphomas, characterised by unique clinical, immunophenotypic and molecular features. Since publication of the 2019 British Society for Haematolog...