University of Manchester

Expanding the BiocatalyticToolbox: A Singular P450Enzyme Efficiently Produces Diverse Pharmaceutical Metabolites

Abstract P450 BM3 is a natural fusion protein with a P450 domain fused to its necessary redox partner and capable of binding a range of fatty acids at high catalytic rates. The flexibility of the active site and catalytic efficiency have led to extensive research aimed at modifyi...

Modelling dynamic blade loads on scaled tidal turbines due to wave-induced unsteady kinematics

Accurate prediction of wave-induced unsteady loads on tidal turbines is essential for reliable fatigue assessment and load mitigation design. These loads arise from the turbine rotating through a depth-varying flow field that oscillates at the wave frequency, requiring detailed m...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Optimizing safety and efficacy of asparaginase and blinatumomab therapy in frontline acute lymphoblastic leukemia regimens in diverse health care settings—international expert consensus

Frontline blinatumomab combined with chemotherapy has resulted in improved outcomes in both pediatric and adult patients with acute lymphoblastic leukemia and is considered the new cornerstone of acute lymphoblastic leukemia treatment. The role of asparaginase in this new landsca...

Temporal- and Spatial-Resolved Characterization of Zeolite-Based Catalysts

Abstract Zeolites and metal-zeolite catalysts are the cornerstones of heterogeneous catalysis, where performance is governed by the structural dynamics and spatial distribution of active sites. However, conventional characterization often lacks the spatiotemporal resolution neede...

Top, Bottom, or Versatile? Sexual Role Trends Across Generations and Regions on a Gay Dating App

Understanding how men who have sex with men (MSM) identify with sexual role labels such as Top, Bottom, or Versatile offers descriptive insights into how sexuality, identity, and self-presentation intersect on dating platforms. Drawing on cross-sectional data from 141,156 active...

Parental socioeconomic position, childhood poverty and healthy aging: retrospective and prospective study of six cohorts across 32 wealthy and developing nations

Background and aim Children who were poor in wealthy countries have reported worse cognitive, muscle, and mental functions, as well as greater frailty and multimorbidity, in later life. However, it remains unclear whether those who were poor in childhood worldwide fall short of h...

A national-scale assessment of the impact of canals on urban temperatures

Abstract Urban populations are particularly vulnerable to heat-related mortality and morbidity. Climate-responsive urban design, which can include development of green and bluespaces, has the potential to offset climate change-related impacts. Compared to greenspaces, the effects...

The Role of Neurofilaments in Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS), the most common type of motor neurone disease (MND), is a devastating diagnosis that often leads to mortality within 2–5 years of symptom onset. Respiratory failure and aspiration pneumonia both associated with respiratory muscle w...

Correlated insulator Moiré bolometer

Light incident on an insulator is generally not expected to turn it into a metal without invoking intense ultrafast excitation that leads to transient structural transitions. Here we show that magic-angle twisted bilayer graphene tuned to half filling of the moiré band provides a...

Technical note: reconstructing dose distributions from manually planned electron boosts in breast radiotherapy

Purpose In breast radiotherapy, delivery of manually-calculated electron boosts limits retrospective dose–response analyses as dose distribution is unavailable. This work evaluates the feasibility of reconstructing dose distributions from manually planned electron boosts in breas...

Observation of single antiferromagnetic magnon modes through tunneling spectroscopy of spin-1/2 Kitaev system α-RuCl3

The small-gap room-temperature semiconductor α-RuCl3, which is known to undergo a Mott-Hubbard transition at low temperatures, is one of the most promising candidates for realization of an exotic matter form, the quantum spin liquid state, which may have applications in quantum c...

Holocene hydroclimatic variability and multi-frequency analyses at Lake Sidi Ali (Morocco)

Abstract. The North African desert margin is considered one of the most sensitive areas to future climate changes, yet the periodicities, coupling mechanisms and external forcing of Holocene environmental variability remain poorly understood. To investigate millennial- to centenn...

Unstructured time as a pathway from disadvantage exposure to crime: The role of time away from school

This study analyzes linked administrative data for 4,926,067 individuals born in England between the 1990/91 and 1997/98 school-year cohorts, followed up to age 30, to examine whether the effect of exposure to economic disadvantage during childhood on later crime involvement is m...

Exploring the sociological determinants of large family size and population growth in Northern Nigeria

Large family size and population growth have been shown to impact the global disease burden and contribute to underdevelopment, especially in low-resource settings, such as Northern Nigeria. This study explored the determinants of large family size and population growth in Northe...

Conceptual schema inference for tabular datasets using large language models

Abstract Large collections of tabular data from data lakes, web tables and open data portals often originate from heterogeneous sources, leading to representational inconsistencies. Understanding and organizing such repositories therefore remains a major challenge. While prior wo...

Cognitive-behavioral suicide prevention for psychosis in community mental health: A pilot randomized clinical trial

Adults with schizophrenia spectrum disorders (SSDs) have substantially elevated suicide risk, yet few suicide prevention interventions have been developed or tested for this population. The effectiveness of Cognitive-Behavioral Suicide Prevention for psychosis (CBSPp) in US commu...

Understanding Caregivers’ Experiences of Rett Syndrome: A Multinational Study of Symptoms and Meaningful Outcomes of Potential Treatments

Caregivers have first-hand experience of facing the daily challenges of Rett syndrome (RTT). The aim of this study was to understand caregivers’ experiences of RTT, including challenging symptoms that caregivers hope novel therapies will address. This non-interventional, qualitat...

Frontotemporal dementia with right temporal predominance: a clinical comparison with left-predominant FTD

BACKGROUND: The right-temporal variant of frontotemporal dementia (FTD) is well characterised. Whether it should be considered a distinct clinical entity, separate from other syndromes of FTD, remains an open question. The study addressed the issue through a retrospective compari...

The Role of Autophagy and Potential Drug Targets in Cardiovascular Disease

Autophagy is integral in the protection and survival of cardiomyocytes in heart disease. If impaired, it can lead to apoptosis of healthy cardiac tissue. This review discusses the role of autophagy in heart disease. Primary mechanisms and their benefits for cellular homeostasis i...