University of Manchester

Autonomy, agency and value: an intrinsic approach to the value of autonomy does not escape the expressivist objection – a reply to Long

Long’s argument that an intrinsic approach to the value of autonomy could allow an autonomy-based approach to assisted dying to avoid the expressivist objection fails because autonomy is not the only morally valuable goal, so moral values other than autonomy also require consider...

The influence of hypoxia on cancer lipid metabolism: a scoping review

Abstract Background Hypoxia, a hallmark of solid tumours, profoundly alters cellular metabolism to enable survival in the harsh tumour microenvironment. Whilst effects on carbohydrate and protein metabolism are well characterised, the hypoxic regulation of lipid metabolism remain...

Comparison of treatment pathways for isolated mesh associated pain syndrome (I‐ MAPS ) secondary to pelvic mesh devices for stress urinary incontinence ( SUI )

OBJECTIVE: The aim of this retrospective observational cohort study was to compare the outcome of surgical, combined and non-surgical pathways of isolated mesh associated pain syndrome (I-MAPS) following insertion of a single continence tape. METHODS: Women with a single continen...

Reimagining land system science in seascapes

Abstract Context Terrestrial concepts often guide the science and management of marine systems, as exhibited by the influence of landscape ecology on seascape ecology. However, the theoretical assumptions that inform these concepts have not been sufficiently interrogated within t...

Analysis of drug development risks for metabolic dysfunction-associated steatotic liver disease from a sustainable accounting perspective

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most common chronic liver diseases worldwide [1], and its targeted therapy and new drug development have drawn extensive global attention. Prior relevant studies mainly focus on the...

Ketamine Uropathy: Critical Role of Imaging and Lessons from an Iatrogenic Complication: A Case Report

Introduction: Ketamine-induced uropathy (KIU) is an increasingly recognised condition with significant implications for urological health. It may present insidiously, particularly when patients conceal recreational drug use, posing diagnostic and procedural challenges. Case Repor...

Priorities for breast cancer risk assessment in UK women under age 50: a survey and discrete choice experiment

BACKGROUND: National guidelines recommend English women between 30 and 49 years with moderate/high risk of breast cancer (BC) be offered screening and prevention interventions. Identification largely relies on family history-based criteria amongst women self-presenting in primary...

Analysis of cancer mutations introduced into the Drosophila melanogaster Notch negative regulatory region uncovers a diversity of regulatory outcomes

Activating mutations of Notch are drivers of the blood cell cancer, T-ALL, and some solid tumours. The negative regulatory region (NRR) of the extracellular domain (ECD) and the PEST region of the intracellular domain (ICD) are mutation hot spots which can act synergistically in...

Implementation of minimum unit pricing for alcohol in Scotland and subsequent rates of hospital-admitted self-harm: controlled interrupted time series analysis

BACKGROUND: Harmful alcohol use is a major modifiable risk factor for self-harm. We aimed to examine associations between minimum unit pricing for alcohol, introduced in Scotland in 2018, and rates of hospital-admitted self-harm. METHODS: Data were obtained from Public Health Sco...

Exploring Decisional Factors to Include Approaches in a Patient Decision Aid for Juvenile Idiopathic Arthritis Symptom Management

Objectives Youth with juvenile idiopathic arthritis (JIA) experience physical and mental health symptoms that negatively impact their participation in daily life activities. The JIA Option Map is a web-based patient decision aid (PDA) created to facilitate decision-making for JIA...

Exploring Training Needs to Facilitate Shared Decision Making in Juvenile Idiopathic Arthritis Symptom Management and the Use of the JIA Option Map

Objectives Our team developed the JIA Option Map, a web-based patient decision aid (PDA) designed to support shared decision-making (SDM) for juvenile idiopathic arthritis (JIA) symptom management. Since training for health care providers (HCP) can enhance SDM and the use of PDAs...

Periprosthetic joint infection

Infection is one of the most devastating complications following arthroplasty. The National Institute for Health and Care Research (NIHR) funded the multinational INFection ORthopaedic Management (INFORM) research programme to study this problem comprehensively, and then funded I...

Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring

Abstract Liquid biopsy has emerged as a transformative development in oncology, enabling the minimally invasive detection and monitoring of cancer through the analysis of tumor-derived material in blood. Moving beyond single-variable analysis, multifeature sequencing-based liquid...

Flow diagnostic-free methodology for identifying propeller recirculation onset in anechoic chambers

Acoustic testing of propellers in enclosed environments presents a fundamental challenge in reproducing static free-flight conditions due to the onset of flow recirculation, as reported in previous studies. Building on the concept of a facility time-scale parameter, this paper pr...