University of Manchester

A fast radio burst at redshift 2, three billion years after the Big Bang

Fast radio bursts (FRBs) are millisecond-duration radio transients from extragalactic sources. Their frequency and polarization properties are affected by plasma and magnetic fields along the line of sight to Earth. We report radio observations of FRB 20240304B and near-infrared...

Beyond the locus coeruleus: pupil dynamics as a systems-level marker of neuromodulatory influences on hippocampal memory

Dopamine and norepinephrine regulate hippocampal plasticity through molecular, cellular and circuit mechanisms that shape which experiences are encoded and later remembered. Translating these mechanisms into human memory research remains challenging because direct measures of end...

A Bistable UV-Sensitive Opsin from a Reef Building Coral Showing a Switchable and Tunable Regulation of Gs-Signaling by Different Wavelengths of Light

Abstract Cnidarians possess a large number of opsins in their genomes for their various photoreceptive functions. In particular, they uniquely possess Gs-coupled opsins that induce intracellular cAMP accumulation in a light-dependent manner. These Gs-coupled opsins, cnidopsins, a...

Mothers’ experiences of bonding with their subsequent child following a previous perinatal bereavement

Introduction Perinatal bereavement can significantly affect a woman’s psychological wellbeing and shape subsequent experiences of pregnancy and motherhood. However, no studies to date have qualitatively explored the impact of different types of perinatal bereavement experiences o...

Creating an Ear and Hearing Health Culture for Professional Ear Users: Current Perspectives on Challenges, Management, and Recommendations

Professional ear users (PEUs), including musicians, instrument makers, or sound engineers, depend on highly trained auditory abilities for occupational performance. Given these demands, PEUs may benefit from tailored prevention, diagnostics, and treatment. Ear and hearing disorde...

Spatiotemporal dynamics and fatality risk patterns of road traffic crashes in Nigeria (2020–2024)

Abstract Background Road traffic crashes pose a significant public health issue in Nigeria, but there is limited national-level analysis of their spatial and temporal patterns. This study investigates the distribution, temporal trends, and severity of reported road traffic crashe...

Bandwidth-Limited Critical Currents in Electrically Tunable Moire Bands

Abstract Moiré superlattices host narrow minibands whose bandwidth governs correlated and topological phases. Here, we demonstrate that the bandwidth also sets the critical current for the onset of out-of-equilibrium transport. In bilayer graphene aligned to hexagonal boron nitr...

Mapping equity-relevant inputs of AI mental health tools to routine primary care data: a population-based study of 7.19 million adults with multiple long-term conditions in England

Abstract Background Artificial intelligence-enabled tools are increasingly used to support mental health diagnosis, triage and clinical decision-making. However, limited evidence exists on whether these tools incorporate equity-relevant population characteristics, particularly am...

Parallel retinal and circadian signalling channels organise mouse hypothalamic activity

Abstract Background Mammalian physiology exhibits pronounced daily changes, canonically under control of a primary clock in the suprachiasmatic nucleus (SCN). Retinal signals align robust diurnal rhythms in SCN output that are commonly viewed as acting to suppress daytime activit...

Tunable Raman Scattering of Fe(II) Coordination Networks With Magnetic Fields

ABSTRACT Controlling terahertz (THz) waves is important for next‐generation communications, sensing, and imaging technologies. However, it is still unclear precisely how THz signals can be manipulated by various materials. Herein, we report the design and synthesis of four coordi...

Developing Sustainable Chemistry with AI

Conspectus Today we are experiencing an unprecedentedly rapid transformation of science, driven by advances in computing and artificial intelligence (AI). At the same time, there are growing cumulative pressures of climate change impacts that not only affect economies but are cre...

Benchmarking ZenoSWATH-DIA and Rapid-Gradient Workflows for Plasma Proteomics

Abstract Proteomics is the large-scale study of proteins. Mass spectrometry (MS) is one of the most informative techniques for analyzing proteins. Proteomics-based MS examines biological changes in diseases. It also identifies potential biomarker candidates in early disease stage...

Research on Metal Surface Defect Evaluation Based on DualBranch-SSMNet and Supervised Contrastive Learning

Surface defect assessment of metallic workpieces is critical for industrial production and structural safety. Although eddy current testing provides non-contact and nondestructive inspection advantages, existing deep learning methods still suffer from insufficient long-range depe...

Bulk ferroelectric heterostructures

Interfaces in oxide heterostructures act as critical regions to induce emergent and novel types of functionality in thin films. Herein, we demonstrate the creation of bulk ferroelectric heterostructures (BFHs) in monolithic ferroelectrics by nanoscale elemental partitioning, unlo...

A crystalline uranium Fischer-type carbyne

Abstract Since their discovery in 1973, transition metal Fischer carbynes have become a foundational class of metal–carbon triple bond in organometallic chemistry. However, even though the uranium Fischer carbyne bonding motif has been a fundamental target in f -element chemistry...

Representation and Structural Change in Physical Modelling

This paper examines how different physical modelling frameworks represent structural change and asks when the organisation through which physical interactions occur should itself form part of the model state. The literature spans classical continuum mechanics and internal-variabl...

Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection

Many helminth parasites migrate through multiple host organs during infection, but how immune responses are relayed across these tissues is still poorly understood. To investigate the immune aspects of intertissue communication during infection, we established a percutaneous infe...

Generalized Nonlinear Bayesian Pulsar Timing with ENTERPRISE

Abstract We use the Bayesian methods in the ENTERPRISE package to examine the fully general parameterization of pulsar timing models in tandem with noise. We investigate four pulsars, PSRs J1600–3053, J2043+1711, J0740+6620, and J1640+2224, through the lens of Bayesian timing. We...

Targeted community screening in areas of high socioeconomic deprivation enhances the detection of liver fibrosis.

BACKGROUND: Risk-factor-based community screening has been used to identify early liver disease. Risk-factor prevalence and liver-related outcomes are significantly affected by socioeconomic deprivation. However, the impact on targeted community screening is unknown. We evaluated...

Shear‐Thinning Rheology Reshapes Hydrodynamic Dispersion in Heterogeneous Fractures

Abstract Hydrodynamic dispersion of shear‐thinning fluid in fractured rocks is jointly governed by fracture heterogeneity and fluid rheology, yet the way aperture correlation length alters dispersion mechanisms remains unclear. Here, we carry out pore‐scale lattice Boltzmann simu...