University of Lausanne

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show...

Digital transformation in the global south: Balancing risks and building resilience

Digital transformation (DT) is increasingly recognized as vital to enhancing the organizational performance of public sector worldwide. Yet many DT projects fail to achieve their intended outcomes. We argue that these failures are partly attributable to the risk environments surr...

Unveiling fake artworks: using automatic classification based on freely available information

Purpose In the dynamic art market, fake artworks pose a significant threat to cultural heritage preservation. This article aims to introduce a novel approach to enhancing art fraud prevention through the application of computer-based art classification techniques. Design/methodol...

Validation of a modular low-fidelity training model for biportal endoscopic spine surgery

OBJECTIVE: Spinal endoscopy is associated with a steep learning curve, in part owing to its limited depth perception, which increases the need for training models. This study aimed to investigate construct and predictive validity of the Endobox as a low-fidelity training model fo...

A novel classification system for anterior femoral notching in total knee arthroplasty

Abstract Background Femoral notching in Total Knee Arthroplasty (TKA) is traditionally associated with an increased risk of periprosthetic fracture in cases of excessive anterior resection. Beyond fracture risk, notching can influence implant fit, patellofemoral and tibiofemoral...

Session-by-session client feeling and clarification processes over the course of emotion-focused therapy

Background: Emotion-Focused Therapy (EFT) is an effective form of psychotherapy for a range of psychological problems.While earlier research demonstrated the effect of in-session processes as being central for explaining the effects of EFT, it is unclear what the role of client's...

Defining fever-related discomfort in children: an international Delphi consensus

Fever is one of the most common symptoms in childhood and a frequent reason for medical consultation. Current guidelines recommend treating fever only when discomfort is present. However, the concept of fever-related discomfort remains poorly defined and inconsistently applied in...

Laboratory and wild Drosophila sechellia have conserved niche specialization phenotypes

Abstract Many studies investigating the proximate causes of evolutionary adaptations dissect potentially adaptive phenotypes under laboratory conditions where organisms are more easily experimentally manipulated. For such models, it remains unclear if organisms maintained long-te...

Functional metatranscriptomics of the rhizosphere: Towards an understanding of metabolic processes of the microbial carbon pump

Abstract The soil microbiome drives soil organic carbon (SOC) transformation, shaped and impacted by plant growth stage and soil management such as tillage. The soil microbial carbon pump conceptually links the degradation of plant- and microbe-derived compounds and the neosynthe...

Architectural traits constrain the evolution of unisexual flowers and sexual segregation within inflorescences: an interspecific approach

ABSTRACT Male and female unisexual flowers have repeatedly evolved from the ancestral bisexual flowers in different lineages of flowering plants. This sex specialization in different flowers often occurs within inflorescences. We hypothesize that inflorescence architecture may im...

Should valve leaflet thickening be considered a characteristic lesion of infective endocarditis?

BACKGROUND: Valve leaflet thickening was recently incorporated into the 2023 version of the Duke criteria by the European Society of Cardiology (ESC) as a potential imaging marker of infective endocarditis (IE). The study aimed to assess the impact of valve leaflet thickening on...

Long-term occupational upgrading and party support in German districts

Abstract While the structural transformation of Western economies has deepened spatial inequality and polarised voting behaviour, we lack a nuanced understanding of how the resulting regional occupational change maps onto electoral outcomes. Focusing on Germany, this article exam...

Impact of living and training at low altitude for several years on endurance performance at higher altitude: Myth or reality

Abstract The physiological adaptations of long‐term high‐altitude residents without high‐altitude genetic ancestry remain poorly characterized. This study investigated whether permanent residence at low altitude (1200 m) influences performance at higher altitude (2500 m). We comp...

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The re...

The influence of El Niño-Southern Oscillation on cool-season precipitation variability in the arid Middle East

Abstract. Interannual variability in precipitation across the Middle East is of high societal and environmental relevance given the region's arid climate and limited water resources. While previous studies have linked the El Niño-Southern Oscillation (ENSO) to interannual precipi...

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

From digital to physical model: testing of a workflow for case-specific 3D-printed bone simulants

Bone simulants are used for a variety of purposes in wound ballistic experimentation. Synthetic simulants have several advantages over biological (either human or animal) material. Generic synthetic simulants are available, but the shapes and sizes of these materials cannot cover...

Microbial inoculants for soil restoration: A Risk-Proportional Stewardship Framework Integrating Strain-Resolved Genomics and Adaptive Governance

Abstract Global soil degradation and increasing reliance on chemical inputs threaten agricultural sustainability, driving interest in microbial inoculants as tools for soil restoration. These biological products have the potential to enhance nutrient cycling, improve soil structu...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...