University of Lausanne

A TERRA-NONO axis drives fibroblast reprogramming in cancer

The molecular mechanisms linking chromosome homeostasis to fibroblast reprogramming into cancer-associated fibroblasts (CAFs) remain poorly understood. Here, we identify a clinically relevant, telomere-associated nuclear pathway driving CAF activation across multiple human cancer...

Characterization of chemoresistant cell populations improves risk stratification and therapy prediction in pediatric acute myeloid leukemia

Most pediatric acute myeloid leukemia (pAML) patients achieve complete remission after chemotherapy, yet nearly 40% ultimately relapse and die from their disease. High risk cases are typically referred for stem cell transplantation (SCT) in first remission, but because SCT is ass...

CSR officers as heterodox brokers in Kanaky New Caledonia: Travelling models and spatialising effects

Abstract Nickel extraction and processing have profoundly shaped Kanaky New Caledonia's social, political and colonial/decolonial trajectory over the past 150 years. This activity has transformed material and mental landscapes while generating intermediary officers whose roles ev...

Mediterranean cyclones from pre-industrial to future climate: changes in extreme wind, precipitation and compound precipitation–wind events

The Mediterranean is a major extratropical cyclone hotspot and heavily impacted by climate change. The aim of this study is to investigate the impact of future climate change with respect to pre-industrial conditions on extreme cyclones (EXCs) which induce extreme wind, precipita...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

Simultaneous Inference of Flora‐Wide Nuclear and Plastid Phylogenies Using Angiosperms353 Sequence Capture Data

ABSTRACT Accurate knowledge of phylogenetic relationships and divergence time among plant species composing a regional flora is crucial for understanding the origin of the biodiversity patterns we observe today. Despite advances in phylogenomics, resources available for reconstru...

Mountain glacier evolution since the last interglacial

Abstract. Mountain glacier evolution since the last interglacial remains poorly constrained, with limited spatial and temporal coverage. Conventional modelling approaches typically target major climatic events, operate at coarse spatial resolution over limited spatial domains, or...

Afghanite: A New Silicate‐Matrix Reference Material for In Situ Halogen and Sulfur Microanalysis

Sulfur (S) and the halogens (F, Cl, Br, I) play key roles in geochemical processes that govern volatile cycling, redox evolution, phase reactions and ore formation in the Earth's crust and mantle. Quantifying these elements in situ requires well‐characterised reference materials...

Impact of a Specialized Care Pathway for ICU Patients With Disorders of Consciousness: Observational Insights From an Expert Center

ABSTRACT Background Management of lasting disorders of consciousness (DoC) is complex and sometimes requires referral of patients to an expert team. We aimed to evaluate the impact of such specialized expert assessment through the description of a single‐center experience. Method...

Is it safe to resume continuous positive airway pressure therapy early after endoscopic transsphenoidal surgery? An illustrated narrative review

Background Although the timing of continuous positive airway pressure (CPAP) resumption after endoscopic transsphenoidal surgery (ETSS) remains controversial in the absence of definitive evidence, recent literature suggests early CPAP resumption may be safer than historically ass...

Intensity and instability of affective and cognitive states in borderline personality disorder compared to remitted mood disorders and population-based controls: an Ecological Momentary Assessment study

Abstract Background Ecological Momentary Assessment (EMA) is one of the methods of choice for the evaluation of affective dynamics. Several studies have been conducted on the subject focusing on borderline personality disorder (BPD). However, most have only compared BPD to health...

Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ

Abstract The arms race of bacteriophages and their bacterial hosts has inspired major breakthroughs in biotechnology and shaped phages as fierce predators with great clinical potential to fight multidrug-resistant bacterial pathogens. However, the large amount of genes of unknown...

Which senses do wild vervet monkeys (Chlorocebus pygerythrus) use to evaluate potential food?

Abstract Traditionally, primates have been considered primarily visual animals. However, studies across a variety of taxa suggest that, in the context of food evaluation, reliance on this sense might be more nuanced that previously thought, with dietary specialization and food it...

Multimodal imaging reveals no evidence for magnetite-based magnetoreceptors in the mole-rat eye

Magnetoreception is widespread across animals, but its sensory mechanism remains unresolved. One leading hypothesis proposes that single-domain magnetite is coupled to mechanosensitive ion channels. In subterranean Ansell's mole-rats, such receptors have been proposed to reside i...

Rethinking norms in the Outer Circle: The case of Namibian English

Abstract The article revisits Schneider and Schröder’s (2021) assessment of Namibian English (NamE) as a ‘non‑postcolonial’ variety that has moved from a phase of diffuse normative input into a yet uncompleted Phase 3 (‘nativization’) and that – due to ‘ethnic variation’ – remain...

Repulsive serial dependence in visual working memory modulated by target fidelity

Visual representations are open to systematic functional biases. In visual working memory, representations of serially presented stimuli can either attract or repel each other. Such serial dependence biases are thought to reflect adaptive Bayesian processes yielding optimal perce...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Retinalysis-Vascx: An Explainable Software Toolbox for the Extraction of Retinal Vascular Biomarkers From Color Fundus Images

Purpose: Automatic extraction of retinal vascular biomarkers from color fundus images (CFIs) is crucial for large-scale studies of the retinal vasculature. We present VascX, an open-source software toolbox that extracts biomarkers from CFI artery-vein segmentations. Methods: From...

SAGE: An Expert-Annotated South Asian GI Endoscopy Dataset for Multimodal Learning and Hallucination Analysis

Gastrointestinal cancers represent a growing health burden in the South Asian region, driven largely by rapid changes in socio-economic conditions and lifestyle habits. However, early diagnosis remains limited by inadequate equipment, financial resources, and scarce GI expertise....

Evolution of zinc biomarkers and impact on clinical nutrition and public health

Purpose of review Zinc deficiency is a major modifiable nutritional and public health burden worldwide. Because zinc participates in a wide range of biochemical functions, the physiological consequences of deficiency are diverse and nonspecific, complicating the identification of...