University of Lausanne

Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells

Abstract Multicellular self-organization depends on interactions across multiple length scales, yet mapping protein states at high spatial resolution in whole-mount embryos remains challenging. Here, we introduce high-throughput 3D in toto iterative immunofluorescence imaging (3D...

The Road to Nowhere: Being Rooted in a Region Does Little to Predict Support for Populist Parties or Opposition to Migration and Social Change

ABSTRACT In his influential book The road to somewhere David Goodhart claims that a split between a majority of people who are rooted in particular places or groups (the “Somewheres”) and a minority of people who are or can be at home anywhere in the world (the “Anywheres”) is at...

Long-term outcomes of balloon dilation of the eustachian tube under local anesthesia

PURPOSE: To evaluate the long-term outcomes, safety, and feasibility of balloon dilation of the Eustachian tube (BDET) performed under local anesthesia in patients with baro-challenge-induced and obstructive Eustachian tube dysfunction (ETD). METHODS: This prospective observation...

A disulfide bond sculpts the CTNIP4 phytocytokine fold for recognition by the receptor kinase HSL3

Abstract Precise ligand recognition by closely related leucine-rich repeat receptor kinases (LRR-RKs) is essential for plants to coordinate immunity, development and environmental adaptation. Here we show how the LRR-RK HSL3/NUT specifically recognizes the folded, disulfide-stabi...

Anomalous fading correction in luminescence dating – a mathematical reappraisal

Anomalous fading is a power law decay of trapped charge over time that is commonly observed in wide-bandgap semiconductors, leading to age underestimation in luminescence dating if unaccounted for. In this paper, we reappraise the mathematical foundations of luminescence signal c...

Estimation of NATM excavation-support classes at tunnel excavation faces using a deep learning algorithm

Accurate determination of the geotechnical conditions at the tunnel face is essential for ensuring safe and effective excavation and support operations during tunnel construction with New Austrian Tunnelling Method (NATM). Therefore, engineering geologists carefully and systemati...

Nutrient stress reduces the extent but increases the intensity of root-driven destabilization of mineral-associated organic matter

Abstract Mineral-associated organic matter (MAOM) constitutes a vast terrestrial carbon reservoir, yet its vulnerability to plant root activity remains poorly constrained. Here, we show that MAOM destabilization by plant roots is governed by two distinct factors: the overall exte...

Desire for group supremacy: the role of social dominance orientation for social policy attitudes

Abstract A key concern in the social policy literature is to understand the causes of support for – but also opposition to – egalitarian and inclusive policies and for political parties that champion such policies. While objective socio-economic factors such as class and gender h...

Characterization and Applications of the Protein Corona Forming on the Naturally Occurring Nanoparticles, Low-Density Lipoproteins

Abstract Low-density lipoproteins (LDL) are naturally occurring, monodisperse nanoparticles composed of proteins and lipids with an average diameter of 18–25 nm. Their biological functions such as cholesterol trafficking and their role in various diseases have been extensively st...

The role of multisensory integration in child development: Perception, cognition, and action

Multisensory integration (MSI) is a cornerstone of human development, essential for how children perceive, interact with, and understand the world. This review proposes that the developmental trajectory of MSI is characterized by asynchronous maturation of the different sensory s...

Self-tracking inequalities in public health: Mapping the landscape and identifying avenues for research

While extensive research has been conducted on self-tracking (using devices like smartwatches to monitor behaviours), few studies have investigated the question of inequalities within this area. This creates a critical knowledge gap at a time when self-tracking is rapidly expandi...

Real-time volatilomics reveals microbiota and pathogen fingerprints in the honey bee

ABSTRACT Understanding the complex relationship between gut microbiota and their hosts often relies on invasive sampling techniques. Honey bees provide a tractable model for host-microbe studies. Here we establish single-bee volatilomics using secondary electrospray ionization (S...

The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia

Abstract Amphioxus (Cephalochordata) are small marine chordates that have broad ecological ranges, yet as adults form local settlements and exhibit limited mobility. Genomic surveys of two amphioxus species have suggested that they rank among the most genetically diverse metazoan...

Long-term temperature, oxygen and water clarity trends in Swiss lakes

Abstract. Water temperature, electrical conductivity, dissolved oxygen concentration, and water clarity are key variables routinely measured in Swiss lakes by lake monitoring programs run by cantonal environmental offices and international lake commissions. In most lakes, data is...

Invited perspectives: Towards usable compound event research

Abstract. Supporting stakeholders with science-based decision-making to mitigate and adapt to climate change impacts is a central mandate of the climate research community. In particular, mapping out scenario-dependent climate risk landscapes is one of the most pressing challenge...

Higher-order interactions in brain microstructure reveal a redundancy-to-synergy crossover in quantitative MRI for multimodal biophysical modelling

Abstract Multi-parameter mapping (MPM) magnetic resonance imaging (MRI) provides parameters sensitive to myelin, iron and water. Conventional analyses treat these parameters individually or via pairwise correlations. We introduce O-information ( $$\Omega$$ Ω ) as a proof-of-princ...

Bringing the child's and parents’ voices together: French validation of the SMU and STU quality of life questionnaires in pediatric obesity

Background Childhood obesity is associated with significant impairments in health-related quality of life (HRQoL), yet culturally adapted, weight-specific tools are lacking in French-speaking settings. Aim This study aimed to validate French versions of the Sizing Me Up (SMU) and...

Use of Mediterranean Diet Adherence and Physical Activity for Refining Cardiovascular Risk Prediction in the General Population - Insights from the CoLaus/PsyCoLaus Study

Abstract Aim The SCORE2/SCORE2-OP, recommended for estimating 10-year risk of first atherosclerotic cardiovascular disease (ASCVD), does not include lifestyle factors. We investigated whether adding self-reported physical activity and Mediterranean diet adherence improves predict...

Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinoma

There is limited understanding of the epigenetic drivers of tumor evolution in hepatocellular carcinoma (HCC). Here we characterize the epigenetic contribution of methylation to intra-tumoral heterogeneity (mITH) using regional enhanced reduced-representation bisulfite sequencing...

From grounded consolidation to active detachment: the evolution of work centrality during involuntary career change

Purpose The aim of this paper is to understand how the work centrality of involuntary career changers is shaped by and evolves during the change process. Design/methodology/approach We conducted a qualitative longitudinal study leaning on three waves of semi-structured interviews...