University of Hong Kong

Standard- versus low-dose CBCT in evaluating mandibular canal visibility and its impact on assessing the spatial relationship with mandibular third molars: a comparative analysis

Abstract Objectives To compare the visibility of the mandibular canal (MC) at three mesial-distal levels adjacent to the mandibular third molar (M3M) using standard-dose and four low-dose cone-beam computed tomography (CBCT) protocols, and evaluate their impact on assessing the s...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Distinct constraints but shared dynamics shape the macroevolution of volatile organic compound chemodiversity

Complex metabolic systems have evolved across the tree of life, producing remarkable chemodiversity, yet the structure and evolutionary modes underlying this diversity remain poorly understood. Here, we investigate the macroevolution of chemodiversity using a comprehensive datase...

Optimal Mixing for Randomly Sampling Edge Colorings on Trees Down to the Max Degree

Abstract. We address the convergence rate of Markov chains for randomly generating an edge coloring of a given tree. Our focus is on the Glauber dynamics, which updates the color at a randomly chosen edge in each step. For a tree [Formula: see text] with [Formula: see text] verti...

Understanding Barriers and Motivators of Familial Hypercholesterolemia Genetic Testing: Insights From the Singapore Public

Familial hypercholesterolemia (FH) is a common monogenic disorder associated with elevated low-density lipoprotein cholesterol and premature cardiovascular disease. Despite Singapore's high FH prevalence and the launch of the National FH Genetic Testing Programme in 2025, uptake...

Marital Status, Cohabitation and Intentions of Workers to Move to Less Developed Areas

ABSTRACT While migration for ‘love in destinations’ has gained attention, the link between partnerships, beyond the married‐unmarried dichotomy, in home societies and migration intentions remains underexplored. Meanwhile, economies in the Global South are becoming attractive for...

Far From Home? Accessing Everyday Places in Rural and Urban Communities

OBJECTIVES: Rural residents are believed to experience greater social isolation than their urban counterparts. This isolation is typically attributed to the structural conditions that distinguish rural communities from urban communities. In the present study, we direct attention...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

A Taxonomy and Systematic Review of Driving Automation Failure Scenarios

Before human drivers are fully removed from the vehicle control loop, transitioning control between automation and human drivers in safety-critical scenarios remains a major challenge. Although existing research has proposed several taxonomies to categorize safety-critical scenar...

Epitope-conditioned generation of T-cell receptor β-chain CDR3 candidates using a pre-trained transformer model

Prioritizing T-cell receptor (TCR) candidates for defined peptide-HLA targets is an important step in TCR-based immunotherapy development, but it still relies heavily on laborious and expensive experimental screening. Recent advancements in generative artificial intelligence have...

Metagenome-scale modeling to assess microbiome metabolic complementarity for precision microbiota transplantation therapies

Fecal microbiota transplantation (FMT) holds therapeutic promise beyond recurrent Clostridioides difficile infection, but clinical outcomes remain unpredictable, in part because existing computational models do not fully capture the metabolic compatibility between donor and recip...

Feasibility of Generatively Designed Patient-Specific Implants for Orthognathic Surgery: An In Silico Comparative Study

ABSTRACT Introduction and Aims To investigate whether generatively designed (GD) patient-specific implants are equivalent to manually designed (MD) PSIs for orthognathic surgery in the in silico setting. Methods Twelve pairs of GD and MD fixation plates for Le Fort I osteotomy an...

Fairness‐aware insurance pricing: A multi‐objective optimization approach

Abstract Machine‐learning models can provide accurate predictions in insurance pricing, but can also increase disparities between protected groups. Existing fairness‐aware pricing approaches typically target one fairness notion at a time, making it difficult to compare trade‐offs...

Digitally enabled GP-specialist collaborative care helped improve hypertension outcomes and reduced hospital referrals in China

As China deepens health system reform to strengthen primary care by integrating hospital-based specialist services into community settings, empirical evidence is still limited. This quasi-experimental difference-in-differences analysis examined the effect of the digitally enabled...

Quality or convenience? Behavioral evidence on how facility grade influences urban destination choice

Modeling non-work activity destination choices is essential for urban transportation planning, as these activities involve greater flexibility and more complex behavioral decision-making than mandatory activities. However, existing studies often treat all facilities within the sa...

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

ABSTRACT Planar cell polarity (PCP) signaling is an evolutionarily conserved mechanism regulating polarized cellular and tissue behaviors in diverse morphogenetic and physiological processes. Disruption or aberrant activation of PCP signaling can cause developmental defects or pr...

Intersex variations, social class, and the postcolonial geopolitics of language and healthcare in Hong Kong

In this study I examine how clinicians’ talk about intersex variations in Hong Kong constructs parents as differently educable biopolitical managers of their children, in ways closely tied to social class and to the colonial language economy of English and Cantonese. Using intera...

Exploring meaningful work as a buffer for psychological well-being for women entrepreneurs: does caregiving responsibility matter?

Purpose Drawing on the job demands-resources (JD-R) model, this study explores how meaningful work mitigates caregiving responsibility and psychological well-being among women entrepreneurs. Design/methodology/approach A cross-sectional survey was conducted among 360 women engage...

Nanofibrous aerogels with continuous conductivity gradient for ultrabroadband absorption-dominant electromagnetic interference shielding

Electromagnetic interference (EMI) shields are limited by a severe impedance mismatch with free space, leading to strong reflections and secondary radiation. Here, we introduce ultralight all-polymer aerogels featuring a continuous through-thickness conductivity gradient (MCAs),...

Freestanding Hierarchical‐Porous BCZT Thin Films Enable Efficient Ultrasonic Energy Harvesting in Soft Tissue

ABSTRACT Excellent electromechanical properties of piezoceramic thin films facilitate ultrasonic energy harvesting in bioelectronic systems. However, most piezoceramic thin films are fragile and cannot maintain mechanical integrity under deformation, hindering their application i...