University of Hong Kong

Nigral DJ-1 gene knockout in tree shrews can induce phosphorylated α-synuclein aggregation and all key phenotypes of Parkinson’s disease

Abstract DJ-1 is a genetic factor associated with Parkinson’s disease (PD), and altered DJ-1 function has been implicated in PD pathogenesis. However, DJ-1 knockout mice fail to reproduce robust PD-like phenotypes or neuropathology, leaving the contribution of DJ-1 deficiency to...

From policy debate to empirical evidence: a proof-of-concept bibliometric and LLM-assisted abstract-level content analysis of OTC hearing aid research before and after FDA regulation

Objective To characterise temporal patterns in over-the-counter (OTC) hearing-aid research before and after U.S. Food and Drug Administration (FDA) implementation of the OTC category (effective October 2022), using bibliometrics and large language model (LLM)–assisted abstract-le...

A Wearable Multimodal Assistive Interface for Virtual Cursor Control in Stroke Survivors with Upper-Limb Impairment

Stroke survivors with upper-limb impairments often have difficulty using conventional computer interfaces, which limits their ability to perform daily computer-related activities independently. This study developed a wearable multimodal assistive interface that enables computer i...

Can Information Design Resolve Electric Vehicle Charging Chaos?

Charging remains an obstacle to the mass adoption of electric vehicles (EVs), especially for long-distance travel. If many EV drivers take to the road around the same time, their "range anxiety" may create a self-fulfilling prophecy. As drivers anticipate uncertainty and congesti...

Modelling injury severity of pedestrian crashes on urban road networks: a random-parameter spatial-joint logistic regression approach

Pedestrian crashes on urban road networks are commonly modelled separately for intersections or road segments, potentially overlooking the network-level dependence between physically connected entities. This study developed a random-parameter spatial-joint logistic regression app...

Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members

Study Design Cross-sectional survey. Objective Outcomes research has significantly shaped patient management in spine deformity care, while the dissemination of research remains a challenge. To guide future research directions, this study surveyed AO Spine members to identify the...

Exploring mathematics educational values (MEV) differences in experienced mathematics teachers’ narratives of critical incidents

Abstract Teachers’ instructional decisions reflect underlying pedagogical values, yet limited research examines how teachers recognise and interpret value differences in classroom practice. This study investigates how nine experienced Malaysian secondary mathematics teachers inte...

Dibutyl phthalate disrupts ESR1-GPX4 redox signaling and aggravates ovarian dysfunction in a PCOS-like mouse model

Dibutyl phthalate (DBP), a widely used phthalate plasticizer, has been implicated in reproductive toxicity, but the molecular mechanisms by which experimental DBP exposure affects ovarian granulosa-cell function remain incompletely defined. In an exploratory clinical cohort, urin...

Hotspot to Homogeneous: Amorphous Interfacial Current Redistribution Enables Stable Solid-State Lithium-Metal Batteries

Abstract Interfacial instability in oxide ceramic electrolyte (OCE)-based solid-state lithium metal batteries (SSLMBs) is conventionally attributed to chemical incompatibility or mechanical failure, yet the underlying atomic-scale mechanisms remain elusive. Here, we reveal that g...

Health utility and equity-related correlates among adults with rare diseases in Foshan City, China: an exploratory cross-sectional study using the EQ-5D-5L

Rare diseases (RDs) are associated with substantial and potentially avoidable health inequities related to chronic disability, social disadvantage, and high non-medical costs. Evidence on health-related quality of life (HRQoL) among adults living with RDs in China remains scarce,...

Autophagy in the Regulation of Placental Development: From Trophoblast Differentiation to Metabolic Stress Adaptation

Successful pregnancy depends on precise placental development, where trophoblast differentiation, syncytialization, invasion, and adaptation to metabolic stress are critical. Autophagy, a lysosome-mediated degradation pathway, has emerged as an important regulator of cellular hom...

Multiplicative irreducibility of shifted multiplicative subgroups

Abstract In a recent breakthrough, Kalmynin resolved conjectures of Lev–Sonn and Sárközy on additive decompositions of multiplicative subgroups of prime fields. In this paper, inspired by a related conjecture of Sárközy, we prove multiplicative analogues of Kalmynin's results. We...

Rare Variants May Influence Disease Risk and Clinical Features in Sporadic Late-Onset Chinese Parkinson’s Disease Patients

BackgroundThe heritability in Parkinson’s disease (PD) may be contributed by rare variants (RVs) in candidate genes. Currently there is limited genetic data on Chinese PD patients.ObjectiveWe aim to identify RVs in Chinese PD patients and investigate their relationships with risk...

An exploration of collaboration strategies across levels of co-presence in VR exergames

Abstract Exergames in virtual reality (VR) combine physical activity with engaging social play. \rev{While the benefits of social play are clear, the increasing shift toward remote interaction creates a critical need to understand how embodied collaboration functions when physica...

Optimised murine model of influenza-induced respiratory sepsis for studying acute kidney injury

Abstract Background Viral respiratory sepsis, driven by influenza and COVID-19, is increasingly prominent clinically. However, there is a lack of preclinical models that reliably replicate its associated acute kidney injury (AKI), a major contributor to morbidity and mortality. M...

Does online informal social capital enhance healthcare technology adoption among older adults? The mediating role of attitudes

Healthcare technology adoption is critical for older adults to enhance healthcare access and autonomy. Limited research has examined the effect of social capital on healthcare technology adoption among older adults. Adopting the technology acceptance model and social capital theo...

Gender differences in prolonged grief: a network perspective on symptom interconnections and functional impairment

Background: While prior studies have reported gender differences in prolonged grief symptom severity, less is known about symptom interconnections and their associations with functional impairment. Clarifying these may inform more targeted bereavement care.Methods: A total of 1,0...

Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BRCA Multi-Gene Panel Testing and Cancer Surveillance

Breast cancer remains highly prevalent, where the lifetime risk before age 75 is one in 13. However, known genetic factors were only identified in 14.7% of cases in our Hong Kong Hereditary Breast Cancer Family Registry. Our current local policy for genetic testing does not cover...

Object biography of war relics: a case study on the Japanese pillboxes on Luk Keng Knoll

Abstract In the research context of the growing interest in the object biographies of World War II relics, this case study of the field surveys of the Japanese pillboxes on Luk Keng Knoll, Starling Inlet, in Hong Kong, is a good illustration of an object biography “written” by mi...

The Salience of Entrepreneurship: Evidence from Online Business

We examine the decision to become an entrepreneur in the context of online business. Using data on entrepreneurs from a large e-commerce marketplace in China, we find that individuals are more likely to start online businesses after observing the salient success of nearby stores....