University of Hong Kong

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targ...

More than 79.47% of the zeros of the Riemann zeta function are simple and on the critical line

This preprint presents a certified-candidate proof that, with ineffective constants, more than 79.47% of the nontrivial zeros of the Riemann zeta function are simple and lie on the critical line, and more than 89.73% lie on the critical line. Building on the "two-thirds theorem"...

Unpacking the state-private nexus in China’s AI development path

The Chinese AI regulatory model has been described as state-driven, where the Chinese government seeks technological supremacy by deploying AI to entrench power through surveillance, control, and cooptation of public and private sectors. It is portrayed as a comprehensive, top-do...

EngageCue: Enabling Balanced Engagement in Face-to-Face Group Collaboration via AI Cues Through Smart Glasses

In face-to-face group collaboration, uneven engagement often undermines efficiency and interaction quality. Although AI and wearable devices are increasingly applied to support collaboration, existing approaches largely remain confined to online or screen-based environments, leav...

Peak Shaving and Valley Filling: Reconstructing Cognitive Load in Cultural Heritage VR Through Contextualized Scaffolding

Virtual reality supports immersive cultural heritage communication, yet engagement outpaces understanding. A structural cause is that information about an object is scattered across transient carriers (NPC dialogue, annotations, triggered videos), requiring working-memory integra...

Developing Structurally Uniform Nitrogenous Model Systems to Interrogate the Metal-Free Oxygen Reduction Reaction

Abstract Oxygen reduction reaction (ORR) is a kinetically sluggish reaction under uncatalyzed conditions. Numerous studies have revealed that mixtures of N-doped moieties in graphene improve ORR activity and selectivity. However, due to the surface heterogeneity of N-doped carbon...

Trans-Percept: robust perceptive locomotion in the wild via spatiotemporal causal transformers

The integration of exteroceptive perception with proprioceptive control has revolutionized legged robot locomotion, enabling navigation through complex, non-flat terrains. Miki et al. (2022) established a seminal paradigm by fusing vision and proprioception using Recurrent Neural...

Accuracy assessment of Chinese large language models in psoriasis management: a multicenter expert evaluation study

Psoriasis patients in China face severe barriers to disease knowledge acquisition and limited access to medical resources, creating an urgent demand for reliable, evidence-based patient education tools. This multicenter expert evaluation study aimed to systematically assess the q...

The new first listener: Daydreaming styles and self‐compassion predict adolescent disclosure to AI , differently in ADHD

AI chatbots are rapidly becoming a common place where adolescents first disclose personal experiences, because the interaction is private, always available, and often feels lower-stakes than telling another person. Recent U.S. evidence suggests that about one in eight adolescents...

Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications

Cardiac-related pain, including angina pectoris and pain accompanying myocardial infarction, remains clinically important, and existing treatments are inadequate for some patients. Animal and primary-tissue studies provide important mechanistic evidence, but species differences a...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Redefining Success and Characterizing Midterm Growth Modulation: Analysis of Radiographic Outcomes in 2 Years Following Vertebral Body Tethering.

Background: Vertebral body tethering (VBT) offers fusionless correction for idiopathic scoliosis, yet midterm growth modulation remains poorly characterized. This study established a clinically relevant success criterion and characterized growth modulation kinetics with associate...

Nonlinear Entropy–Enthalpy Correlation forMethane Adsorption on Shale

Abstract The enthalpy–entropy compensation effect is widely recognized in shale gas adsorption studies, where the standard adsorption entropy change is typically reported to vary linearly with the standard adsorption enthalpy change. However, this study reveals that such linear a...

Therapeutic Effects of Forced Running on Osseointegration in Rats With Diabetes

BACKGROUND: Poor osseointegration in diabetes is a significant challenge faced by dental implants; existing strategies are still limited in their effectiveness to fully promote osseointegration. Physical exercise is an important treatment for diabetes and has shown its effect in...

State entrepreneurialism under economic transition: Bounded rationality in China’s high-speed rail new town governance

Drawing on 16 high-speed rail (HSR) new towns along the Beijing–Shanghai corridor, this paper develops a middle-range explanation of how state entrepreneurialism is practiced and differentiated under conditions of economic transition in China. While the notion of state entreprene...

Tokenizing Loyalty Programs: The Role of Tradability

Problem Definition. Loyalty programs (LPs) are widely used to enhance customer retention and firm profitability. With technological advancements like blockchain, many brands are exploring tokenized LPs. Unlike traditional LPs, where rewards can only be redeemed for future purchas...

Empowering PolymericMaterials Discovery by ArtificialIntelligence

Abstract Polymeric materials underpin modern technologies spanning energy storage, microelectronics, healthcare and sustainable manufacturing. Yet their rational design remains exceptionally challenging because material performance emerges from complex interactions among molecula...

Enhanced Antibiotics Sieving by Exfoliated TiS2 Membranes via Surface Functionalization and Passivation

Abstract Transition metal dichalcogenide (TMD) nanolaminate membranes hold great promise for molecular sieving due to their two-dimensional capillary structures, which facilitate size-restricted diffusion. However, many transition metal sulfides exhibit intrinsic instability and...

Automated In-InjectorPort Conversion of AristolochicAcids to Aristolic Acids for Enhanced HPLC Fluorescence Detection

Abstract Aristolochic acids (AAs) and the herbs containing them are recognized human carcinogens. Emerging evidence indicates that AAs are also food and environmental contaminants, posing significant risks to human health. This study developed a highly sensitive AA detection meth...

Outsiders within: exploring integration strategies of international faculty in chinese higher education institutions

Abstract International faculty (IF) are increasingly recruited to Chinese universities to support knowledge transfer and internationalisation, yet they frequently report experiencing persistent marginal positions. This study examines how IF in Chinese higher education navigate th...