University of Colorado Anschutz

Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression

Abstract Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. This observational follow-up study examines brain development and subsequent negative emotionality among 109 infants born to mother...

Social Risk Screening and Referrals in the Pediatric Inpatient Setting

BACKGROUND/OBJECTIVES: Many professional organizations recently recommended inpatient screening for social risks. Although prior studies have explored social risk screening rates in children's hospitals, many excluded community hospitals and lacked detail on screening practices....

Change in hearing loss and its association with general health in a community-based longitudinal study of middle-aged individuals: The Busselton healthy ageing study

Introduction With the ageing of the global population, disabling hearing loss is a major health concern. While age and sex are established determinants, the relation between general and environmental health factors and the progression of hearing loss remains incompletely understo...

ACTN3 Variants Beyond Performance: Metabolic and Inflammatory Implications

Background: Athletic performance is a result of interaction between genetic and environmental factors, including training, nutrition, rest, hormonal and psychophysiological status. Numerous genes and polymorphisms can influence key physiological processes, such as muscle contract...

Intermittent hypoxia interventions for inducing ventilatory acclimatization to high altitude?

Accumulation of ∼200 h of hypoxia exposure (pre-acclimatization) has been suggested to prevent the development of acute mountain sickness when a person is subsequently exposed to high altitude. These pre-exposures are typically undertaken intermittently at or near the place of re...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

From Resection to Transplantation: Rethinking Training and Certification for the Modern HPB Surgeon

Hepatopancreatobiliary (HPB) surgery has evolved beyond the confines of traditional liver and pancreatic resection. Contemporary practice increasingly encompasses advanced vascular reconstruction, extended hepatectomy in compromised livers, transplantation for malignancy, and com...

Use of Anticoagulation Among Patients With Atrial Fibrillation or Atrial Flutter in the United States

BACKGROUND: Oral anticoagulation (OAC) remains underused in patients with atrial fibrillation or flutter at high risk of ischemic stroke. We aimed to characterize documented OAC prescribing at diagnosis and during 1-year follow-up and identify factors associated with baseline OAC...

Hospital wastewater-based antimicrobial resistance epidemiology: a scoping review

Abstract Introduction: Wastewater-based epidemiology (WBE) offers pooled biological samples of defined populations, complementing clinical surveillance for infectious diseases. Hospitals are hotspots for antimicrobial resistance (AMR). We performed a scoping review assessing hosp...

Therapeutic Horseback Riding for Youth With Autism and Psychiatric Comorbidities: A Randomized Trial

OBJECTIVE: Autism spectrum disorder care is often complicated by co-occurring psychiatric symptoms. Equine-assisted services show promise for improving behavioral outcomes in this population. We aimed to examine benefits of equine-assisted services for youth with autism at higher...

The relationship between lean mass and protein intake in females of African and East Asian descent

Low lean mass (LM) is associated with increased cardiometabolic disease risk and increased injury risk. Protein (PRO) intake is an important strategy to build and maintain LM. There is limited data quantifying PRO intake and evaluating the association between PRO intake and LM in...

A single-aortotomy end-to-side technique simplifies murine aortic transplantation

Background Transplant arteriosclerosis remains a major cause of late graft failure after solid organ transplantation. Murine aortic transplantation models have provided important insights into the mechanisms underlying chronic allograft rejection, but the surgical procedure remai...

Gut microbial metabolism of peanuts generates immunoregulatory metabolites

Background. Complementary feeding practices and timing are thought to significantly influence early life immune development, with the early introduction of allergenic foods being especially important for prevention of food allergy. We hypothesized that allergen-containing foods s...

In silico experiments uncover a novel mechanism underlying mutation rate evolution in sexually reproducing populations

Abstract Natural selection is believed to universally work to lower mutation rates (MR) due to the negative impact of mutations on individual fitness. Mutator alleles can be co-selected by genetic linkage with adaptive alleles in asexual organisms. However, sexual reproduction di...

Isolation of diverse nontuberculous mycobacteria from Hawai’i feral pigs and identification of Mycobacterium abscessus subsp. bolletii

Abstract Background Nontuberculous mycobacteria (NTM) are environmentally acquired opportunistic pathogens that can cause recalcitrant pulmonary disease, particularly in susceptible individuals. Hawai’i has a high incidence of NTM infections, meriting a better understanding of th...

Improved Outcomes and Low Rate of Medical Discharge at a Minimum 10‐Year Follow‐Up After Arthroscopic Bankart Repair With Remplissage for “Off‐Track” Engaging Hill‐Sachs Lesions With Subcritical Glenoid Bone Loss in Active‐Duty Servicemembers

Purpose To evaluate long‐term outcomes after arthroscopic Bankart repair with remplissage among active‐duty servicemembers under 45 years old with engaging Hill‐Sachs lesions (HSLs) and subcritical glenoid bone loss (GBL). Methods A retrospective review of prospectively collected...

Race and Ethnicity Are Associated With Physical Impairment Among ICU Survivors

Objectives: To evaluate whether race and ethnicity are associated with increased odds of physical impairment among post-ICU survivors and to assess how impairment influences healthcare utilization after hospital discharge. Design: This was a retrospective cohort study. Setting: T...

Evaluating the Effect of Chromatographic Chelator Modifiers on Metabolite Levels in Untargeted Liquid Chromatography–Mass Spectrometry

Abstract Metal-sensitive metabolites frequently exhibit poor chromatographic performance during liquid chromatography–mass spectrometry (LC-MS) due to analyte interactions with stainless-steel components of the chromatographic system. Although mobile phase chelators are widely us...

Myeloid cell reprogramming drives enhanced defense against Streptococcus pneumoniae lung infection following exposure to commensal Prevotella

Clinical data link the prevalent respiratory tract anaerobe Prevotella with reduced pneumonia mortality, but the mechanisms directing Prevotella regulation of lung immune homeostasis are unclear. Here, single-cell RNA sequencing was employed to define the transcriptional immune s...

Survival and Reoperation After Intralesional Procedures Versus Resection and Reconstruction for Renal Cell Carcinoma Bone Metastases

Background: The management of renal cell carcinoma (RCC) long-bone metastases often involves surgery with either resection and reconstruction (R&R) or intralesional (IL) procedures. Some literature suggests that R&R improves survival and reduces the risk of recurrence and reopera...