University of Colorado Anschutz

Prenatal cannabis exposure associated with altered brain connectivity: neural correlates of cognitive and mental health variability in offspring

Emerging evidence from human and preclinical studies suggests that prenatal cannabis exposure (PCE) may be associated with offspring neurodevelopmental outcomes. Although prior studies have linked PCE to cognitive and mental health differences in offspring, the large-scale functi...

Calibration and count rate performance of NaI(Tl) gamma counters for quantifying the activity 89 Zr radiopharmaceuticals

Abstract Background Quantification of low activity samples using gamma counters is a common technique when investigating the biodistribution of experimental radiopharmaceuticals. Several human and pre‐clinical trials have investigated 89 Zr labeled compounds, utilizing gamma coun...

Linear antibody epitope prediction using AlphaFold2

Defining the binding epitopes of antibodies is essential for understanding how they bind to their antigens and perform their molecular functions. However, while determining linear epitopes of monoclonal antibodies can be accomplished utilizing well-established empirical procedure...

Modified radiation lobectomy as a bridge to curative surgery: tumor response, future liver remnant hypertrophy, and surgical outcomes

Abstract Background Few studies support modified radiation lobectomy (mRL) as a bridge to curative resection. This retrospective study reviews outcomes after mRL. Methods Patients with primary hepatic tumors undergoing mRL 90 Y radioembolization to grow the future liver remnant (...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

Safety Considerations for Hospitalized Children and Adolescents With Obesity

Children and adolescents with obesity make up a growing proportion of hospitalized patients. As a result, pediatric hospital providers are increasingly providing care for patients whose weight meaningfully influences safety during admissions. This review provides practical, evide...

An Fc receptor and IgA functional signature identifies TB disease in children living with HIV

Abstract Background Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). TB disease is difficult to detect with current clinical microbiological, immunological, and radiographic tools. Serological assays that determine levels of...

SPEF1 mediates assembly of central pair microtubule complexes in cilia of Tetrahymena

SPEF1 is a conserved calponin-homology domain protein that decorates the seam of central pair microtubules in the distal segment of motile cilia. Here, we show that in the ciliate Tetrahymena, loss of SPEF1 disrupts the central pair throughout the middle segment, which comprises...

Clinicians’ Experiences With Law Enforcement in a Pediatric Emergency Department

BACKGROUND AND OBJECTIVES: Law enforcement officers (LEOs) are frequently present in emergency departments, where their roles may include accompanying patients, investigating injuries, or responding to safety concerns. Existing research on LEO presence in health care has focused...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...

Sexually Dimorphic Role of Estrogen Receptor α in Preserving Right Ventricular Endothelial Integrity

Abstract Right ventricular (RV) function and adaptation to afterload increase determine survival in pulmonary hypertension (PH). RV adaptation in PH is sexually dimorphic and more preserved in females, mediated by protective estrogen receptor α (ERα) signaling in cardiomyocytes....

MetaHQ: v1.2.0-rc1

Release candidate for v1.2.0 of the MetaHQ data package - data required to utilize the metahq-cli Python package. Changes made: Adds over 360,000 samples and 16,000 studies to the MetaHQ database Harmonized over 89,000 DiSignAtlas sample-level tissue annotations Harmonized over 3...

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort

Background: Increasing exposure to wildfire fine particulate matter (PM 2.5 ) may pose unique risks to fetal development. We assessed associations between prenatal wildfire PM 2.5 exposure and fetal growth outcomes, including birth weight at term, birth weight for gestational age...

Potential Harms of Ocular and Periorbital Topical Vitamin A Application: A Systematic Review and Meta-Analysis

Purpose: Topical vitamin A derivatives (retinoids) are widely used for dermatologic and cosmetic indications and are often applied to the face and periorbital region. Although vitamin A is essential for epithelial integrity and tear film homeostasis, concerns exist regarding pote...

Management strategies in endogenous fungal endophthalmitis: a multi-institutional retrospective cohort study

Background/aims Standardised treatment guidelines for endogenous fungal endophthalmitis (EFE) are lacking. The purpose of this study is to describe treatment strategies and clinical outcomes of eyes with EFE. Methods Retrospective cohort study performed at eight academic institut...

Menopause in the All of Us Research Program: a descriptive summary of electronic health record and survey response across sociodemographic characteristics

ABSTRACT Objective Menopause is a significant physiological transition with implications for health outcomes (e.g., cardiometabolic), yet gaps remain in understanding the menopause transition, including how menopause timing and type influence health outcomes. Large-scale cohort s...

Population genomics reveals multi-scale mechanisms sustaining schistosomiasis re-emergence in a near-elimination setting

Abstract In China, sustained snail control, environmental management, and mass drug administration with praziquantel reduced schistosomiasis to near-elimination levels, yet re-emergence in Sichuan Province during the early 2000s exposed vulnerabilities in late-stage control. We c...

Contribution of Skull Fractures to Traumatic Brain Injury: A Descriptive Analysis of Skull Fracture Classification Within the modified Brain Injury Guidelines

Background Skull fractures are a common heterogenous finding in patients with traumatic brain injury (TBI). Their clinical significance, particularly of displaced and nondisplaced fractures, remains a topic of debate. This study aims to compare injury severity and clinical outcom...

Fragmentation patterns of human telomeric chromatin in plasma cfDNA

ABSTRACT The unique chromatin structure at telomeres protects the linear ends of chromosomes from DNA surveillance machineries. Here, we demonstrate that circulating cell-free DNA (cfDNA) from plasma can map chromatin structure at telomeres. We find that the telomeric 6-mer repea...