University of Colorado Anschutz

Addressing turnover in the child welfare workforce: a research note on high-attenders in a cluster-randomized trial of Resilience Alliance

Introduction: United States’ child welfare agencies have been challenged with workforce turnover. We previously tested an adaptation of Resilience Alliance (RA), a program designed to mitigate the impact of secondary traumatic stress. Results from the randomized trial showed no s...

Outcomes of a Multi-campus, Multi-semester Applied Critical Care Research Elective

Objective The Research in Critical Care Pharmacotherapy elective implemented a novel approach that promoted collaborative research across four campuses for up to four semesters of credit. The impact of a multi-semester research elective on pharmacy student confidence and experien...

Omic risk scores are associated with COPD-related traits across three cohorts

Background: Chronic obstructive pulmonary disease (COPD) exhibits marked heterogeneity in lung function decline, mortality, exacerbations, and other disease-related outcomes. Omic risk scores (ORS) estimate the cumulative contribution of omics, such as the transcriptome, proteome...

Comparative Effectiveness of Continuous Glucose Monitoring Versus Blood Glucose Monitoring in Pregnancy With Diabetes: Systematic Review and Meta-analysis With Trial Sequential Analysis

OBJECTIVE The value of adding continuous glucose monitoring (CGM) to blood glucose monitoring (BGM) during pregnancy is unclear. PURPOSE To clarify CGM's role in pregnancy using meta-analysis, Grading of Recommendations Assessment, Development and Evaluation (GRADE) ratings, harm...

Redefining atrial fibrillation treatment success: patient-defined goals for arrhythmia burden and health-related quality of life

Background: Despite the use of atrial fibrillation (AF) cutoff of 30s as the standard for success in most AF clinical trials, patients consider an AF Severity Scale (AFSS) of ≤ 5 or AF duration ≤ 1 hour as treatment success. Prevalence and factors associated with these patient-de...

Reframing obesity in aging people with HIV: sarcopenic obesity, muscle quality, and frailty

Purpose of review As people with HIV (PWH) age, obesity is increasingly prevalent, yet body weight alone inadequately captures the functional and metabolic consequences of adverse body composition remodeling. This review examines emerging evidence supporting a shift from weight-c...

Placental sphingolipids are altered by maternal obesity and GDM and associated with fetal overgrowth

Maternal obesity and GDM increase the risk of fetal overgrowth. It has been shown that maternal adiponectin, decreased with these pregnancy pathologies, stimulates ceramide synthesis regulating placental nutrient transfer and fetal growth. We hypothesized that placental sphingoli...

Pilot Voided Volume Validation Study: Sound-Based Smartphone Applications Can Accurately Measure Voided Volume

Background/Objectives: The objective of this study was to test the accuracy of two sound-based voided volume measurement applications compared to voided volume based on the measurement of pre- and post-void weight using a high-resolution scale. Methods: Seven male and four female...

Get With The Guidelines–Heart Failure Hospital Participation and Its Association With Guideline-Directed Medical Therapy and Outcomes

Abstract Purpose Despite strong evidence, real-world adoption of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) remains suboptimal. The Get With The Guidelines–Heart Failure (GWTG-HF) program was designed to close gaps in care....

Age and Cannabis Co-Use Are Associated with Differences in Experience and Perceived Benefits of Psilocybin: A Retrospective Study

As psychedelic use increases, understanding how demographic and behavioral factors influence the effects of psychedelics is essential for both research and public health. This cross-sectional retrospective study examined 365 people who currently use psilocybin, analyzing differen...

Combining Commercial Cancer Protein Biomarkers and Benign Fungal Antibodies Improves Diagnostic Accuracy in Pulmonary Nodules.

OBJECTIVE: To evaluate whether adding cancer and histoplasma biomarkers to existing clinical prediction models improves diagnostic accuracy for malignancy in indeterminate pulmonary nodules (IPNs). SUMMARY BACKGROUND DATA: IPNs remain a diagnostic challenge, particularly in regio...

Transcriptional landscape of canine hematopoiesis and cross-species comparisons revealed by single-cell RNA sequencing

Abstract Hematopoiesis is a complex process that begins with hematopoietic stem cells (HSCs) that progressively differentiate into the cellular components found in blood. Dogs develop spontaneous, biologically similar hematopoietic diseases as humans, yet transcriptomic maps of n...

Balancing privacy and performance: the impact of facial defacing on AI in medical imaging

Background Recent NIH Data Management and Sharing (DMS) policy updates and NIH controlled-access data security requirements have increased attention to facial anonymization and controlled-access handling of shared head imaging data. This is particularly relevant for datasets subm...

Genetic modulation of oxycodone self-administration trajectories: from initiation to escalating burst patterns

Opioid Use Disorder (OUD) remains a prominent threat to global health. Genetic background influences the susceptibility of developing OUD, although specific genetic factors remain elusive. Rodent models that differ in susceptibility to escalation and dysregulation of opioid use a...

Extreme Risk Protection Orders Among Military Service Members and Veterans

Importance Service members and veterans who die by suicide disproportionately use firearms. Extreme risk protection orders (ERPOs) temporarily restrict firearm access for individuals deemed at risk of harming themselves or others. Despite elevated firearm-suicide risk among servi...

Extended Follow-Up of Botensilimab Plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer Without Active Liver Metastases

PURPOSE: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti-CTLA-...

Perceptions of surrogate decision-makers of cardiac arrest patients on engaging in research during high emotional distress

The perception that individuals in crisis experience undue psychological burden by participation in research is a barrier to including surrogate decision-makers to critically ill patients in research studies. Importantly, perceptions from those who have engaged as surrogates are...

Comparison of Machine Learning-Based Reporting with Surgeon Reporting of Postoperative Complication in Cardiothoracic Morbidity and Mortality Conferences

BACKGROUND: Traditional morbidity and mortality (M&M) conferences incompletely capture postoperative complications, potentially limiting quality improvement efforts. We developed and validated the Automated Surveillance of Postoperative Infectious and Non-Infectious Complications...

Altered tonsillar microbiome in children with Down syndrome and obstructive sleep apnea

Abstract Background and Objectives Children with Down syndrome (DS) have a high prevalence of obstructive sleep apnea (OSA) due to anatomic, neuromuscular, immunological and metabolic factors, yet the contribution of the tonsillar microbiome to airway obstruction in this populati...

EphA4 Mediates Pro- and Antitumoral Effects Through Upstream Negative Regulation of AKT in Head and Neck Squamous Cell Carcinoma

Head and Neck Head and Neck Squamous Cell Carcinoma (HNSCC) is driven by an immunosuppressive tumor microenvironment (TME). We examined the immune-modulatory role of EphA4 in HNSCC using spatial analysis, multi-compartment RNA-sequencing from Oral Cavity Squamous Cell Carcinoma (...