University of Colorado Anschutz

Barriers to Reducing Subthreshold Phototherapy for Neonatal Jaundice

OBJECTIVE: In a national, multicenter quality improvement (QI) collaborative to reduce subthreshold inpatient phototherapy, the proportion of subthreshold encounters was high at baseline and remained high after the intervention period. This study aimed to assess why clinicians st...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Improving Community-Based Pediatric Health Care Professionals’ Confidence in Providing Suicide Prevention Services

OBJECTIVE: Community-based health care has a vital role in identifying youths at risk for suicide, providing initial interventions, and connecting patients to appropriate services. This study aimed to evaluate the reach and effectiveness of a youth suicide prevention training ser...

GSTT2 Switches from a Homeostatic Antioxidant to a Cell-Cycle-Coupled Factor in Therapy-Resistant Esophageal Adenocarcinoma

Background/Objectives: Glutathione S-transferase theta 2 (GSTT2) is highly expressed in esophageal tissues from African American (AA) compared with European American (EA) individuals, but its localization, regulation, and relevance to esophageal adenocarcinoma progression remain...

Evaluation of a Commercial Pediatric Sepsis Early Detection Alert in the Emergency Department

Importance Screening tools have been implemented with the goal of improving early detection of pediatric sepsis, with limited evidence of effectiveness. The Epic Systems Pediatric Sepsis Early Detection Model (PESM) and its associated clinical alert have been widely implemented i...

Infant and early childhood mental health professionals’ attitudes toward a system of professional endorsement: A quantitative examination of personal factors, professional support, and perceived benefits

Abstract Demand for recognition of the specialized knowledge and skills required of Infant and Early Childhood Mental Health (IECMH) practitioners, researchers, and policymakers resulted in the establishment of standardized professional credentials that document this expertise. H...

TMEM174 deficiency reduces longevity by promoting phosphate-driven vascular calcification

Dysregulation of phosphate homeostasis contributes to reduced longevity and vascular complications in chronic kidney disease and aging. This study investigates the role of TMEM174, a proximal tubule-specific protein, in regulating the phosphate co-transporter NPT2A and its subseq...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Management of Combined Vascular Malformations.

Combined vascular malformations are complex, heterogeneous lesions increasingly classified by anatomic components and genetic drivers, specifically the PI3K/AKT/mTOR pathway (PROS) and RASA1 mutations. These syndromes, including Klippel-Trenaunay, CLOVES, and capillary malformati...

Early and Mid-Term Outcomes of Zone 2 Thoracic Endovascular Aortic Repair With Open Left Subclavian Revascularization Versus Zone 2 Thoracic Branch Endoprosthesis

Objectives: The Gore TAG Thoracic Branch Endoprosthesis (TBE) was the first commercially available device designed for thoracic aortic repair to offer a fully endovascular alternative to open left subclavian artery (LSA) revascularization. In this study, we compared early and mid...

Comparative analysis of endoscopic endonasal far-medial, far-lateral transcondylar and combined approaches to the foramen magnum region: volumetric analysis and quantitative insights on surgical exposure and maneuverability

Abstract Background Surgical access to the anterior craniovertebral junction (CVJ) and foramen magnum region remains technically challenging due to dense neurovascular anatomy and limited working corridors. Although the far-lateral transcondylar and endoscopic far-medial approach...

Cannabis Hyperemesis Syndrome in the Differential Diagnosis of Bathtub Deaths

Cannabis hyperemesis syndrome (CHS) is a condition caused by chronic use of cannabis in which individuals develop severe cyclic vomiting, nausea, and abdominal pain. This report presents two case fatalities of a 38-year-old male and a 44-year-old male, both found in bathtub and s...

Single Cell Cytometry of Mouse Brain Tissue

Suspension mass cytometry can measure 50 or more markers per cell and is not impacted by cellular autofluorescence, making it an appealing platform for comprehensive phenotyping of single cells in tissue with high innate fluorescence, such as brain. However, this organ is challen...

A Phase II Trial Using Grape Seed Extract for Prostate Cancer Patients With Nonmetastatic Prostate‐Specific Antigen Progression After Local Therapy

ABSTRACT Prostate cancer (PCa) is a major cause of cancer‐related death among American men. While androgen deprivation therapy (ADT) is commonly used in the treatment of rising prostate‐specific antigen (PSA) levels after primary therapy, its adverse systemic side effects support...

Demographic correlates of high-concentration cannabis use in Colorado

Abstract Background As cannabis legalization expands, high-concentration cannabis products (such as wax, dabs, and THC oils) are increasingly available. Despite concerns over their heightened risks, limited research has examined who uses high-concentration cannabis and how these...

Behavioral nudges and feedback lead to improved pre-primary teacher practices in Kenya

Many national pre-primary curricula call for classroom practices that support children’s autonomy and teacher-child dialogue, but these practices are observed inconsistently. Teachers in low-resource settings often lack affordable, scalable support and professional development to...

Women’s Attitudes toward the 2024 US Preventive Services Task Force Mammography Screening Guideline

Background: From 2009 to 2024, the US Preventive Services Task Force (USPSTF) recommended that women aged 40 to 49 y make an informed choice about when to begin having mammograms. In 2024, the USPSTF changed its guidelines, recommending biennial screening from age 40 to 74 y. Thi...

Real-world cardiovascular effects of liraglutide: transportability analysis of the LEADER trial

Abstract Appropriate use of recently approved type 2 diabetes treatments depends on external validity of landmark clinical trials (RCTs) in real-world populations that may differ from trial participants. This study transported effect estimates from the Liraglutide Effect and Acti...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...