University of Cologne

Determinants of mutation susceptibility along the genome are largely invariant across human tissues

Abstract Background The propensity for accumulating somatic mutations varies along the genome, which critically influences somatic mosaicism, tumor evolution and the potential role of somatic mutations in the context of age-associated diseases. Genomic factors contributing to the...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

Atomic‐Scale Detection of Néel Vector Switching in the Single‐Layer A‐Type Antiferromagnet Cr 2 S 3 ‐2D

ABSTRACT The detection of Néel vector switching in a single‐layer A‐type antiferromagnet marks an important step toward functional two‐dimensional spintronics. Here, ‐2D, grown on graphene on Ir(110), is established as a first single‐layer A‐type antiferromagnet. Spin‐polarized s...

Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz

ABSTRACT With the growing number of metabolomics and lipidomics studies, robust strategies for bioinformatic analyses are increasingly important. However, the absence of standardized and reproducible workflows, coupled with ambiguous metabolite annotations, hampers effective anal...

‘Oh Dhar Obaran , Oh Cemetery of Bones!’ An Anti-Colonial Song from the Moroccan Rif as a Counter-Archive of Diasporic Memory

This article examines the transnational circulation of the anti-colonial Riffian song Dhar Obaran in contemporary socio-political contexts between Morocco and the Netherlands. Originating from the Rif region of northern Morocco, this epic poem is an essential part of Riffian oral...

SEQUENCES WITH INEQUALITIES

Abstract We consider infinite sequences of positive numbers. The connection between log-concavity and the Bessenrodt–Ono inequality has been the focus of several papers. It has applications in the white noise distribution theory and combinatorics. We improve a recent result by Be...

Benchmarking MeSH-augmented embeddings for biomedical document similarity

<title>Abstract</title> <bold>Background</bold> : The extensive volume of biomedical scientific literature requires efficient methods for retrieving relevant documents based on semantic technologies and biomedical concepts. While embedding-based methods have shown improvements ov...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Kinship Terms and Person Address in the English‐Speaking Sri Lankan Tamil Diaspora

ABSTRACT This article examines the impact of migration, globalization and digitalization on the use of nominal address terms in the English‐speaking Sri Lankan Tamil (SLT) diaspora community by undertaking a corpus analysis of English fiction authored by diaspora members with SLT...

Pre-service teachers' general pedagogical knowledge and pedagogical learning opportunities at entry into induction: comparing traditional and alternative teacher education programs

Globally, increasing numbers of individuals enter the teaching profession through alternative teacher education programs without prior university studies in teacher education or pedagogy. Compared to traditional programs, these alternative programs—for example, lateral entry prog...

Development of a multi-species luciferase-based double-antigen ELISA for the detection of antibodies against influenza A virus H5 clade 2.3.4.4b

ABSTRACT The highly pathogenic avian influenza viruses of subtype H5N1 represent a major threat to animal and public health. The current panzootic with H5 clade 2.3.4.4b has caused numerous, widespread outbreaks in various domestic and wild avian species with high mortalities, ma...

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

Abstract Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs. Phages represent a promising therapeutic alternative to antibiotics owing to their host specificit...

Bovines, buffers and barriers: A social scientific perspective on rewilding in the Kavango‐Zambezi Transfrontier Conservation Area

Abstract Rewilding is an increasingly popular nature conservation strategy globally. Originally, the strategy was formulated around the three C's of Carnivores, Cores and Corridors, which captured the ecological aim of rewilding to restore trophic interactions across large connec...

Conservative and surgical treatment of wrist osteoarthritis: a systematic review

INTRODUCTION: Wrist osteoarthritis leads to pain and functional impairment. Despite conservative treatment options, surgery remains a central therapeutic component. In Germany, the number of patients rose from over 472,000 cases in 2018 to more than 580,000 in 2024. This review e...

Female psychiatrists on screen: Cinematic stereotypes and therapeutic authority, 1935–2021

Throughout the 20th century, women entered psychiatry, yet cinematic representations remained structured by masculinised archetypes such as Dr Evil, Dr Wonderful, and Dr Dippy. This article interrogates depictions of female psychiatrists in nineteen films and one paradigmatic tel...

Stand structural differences along a degradation gradient in the National forest inventory of Georgia

Abstract Forest degradation assessments grounded in measurable structural indicators provide a more reproducible basis for management decisions than qualitative field classifications alone, particularly in ecologically diverse forest systems. Based on data from the first National...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

A genotype-first approach reveals the molecular basis of pyrin inflammasome activation

Mutations in the MEFV gene, which encodes pyrin, are associated with a spectrum of inflammatory conditions called pyrin-associated autoinflammatory diseases (PAADs). Of the 400 MEFV variants listed in the Infevers database, most are classified as variants of uncertain significanc...

Outside Back Cover: Cycloazulenylene

Cycloazulenylene exhibits a remarkably narrow HOMO–LUMO gap, intense absorption in the visible range, and a unique tubular packing in the solid state. In Research Article e2204400, Tomáš Slanina, Oliver Dumele, and co-workers strained the nonalternant azulene, known for its anti-...

Warum finanzielle Anreize verpuffen: Verhaltensökonomische Perspektiven auf wirtschaftspolitische Maßnahmen in der Energiekrise

Zusammenfassung Vor dem Hintergrund der Energiekrise 2022/23 und der Gefahr einer Gasmangellage suchte die deutsche Wirtschaftspolitik das Verbrauchsverhalten der Haushalte durch finanzielle Anreize zu beeinflussen. Markus Dertwinkel-Kalt und Matthias Sutter analysieren, warum hi...