University of Chicago

Canonicalizing the Wrong Thing: Quotient-Aligned Gauge Fixing for Semantic Representations

This preprint studies when prediction-equivalent representations are interchangeable under a declared downstream interface. It formalizes quotient-aligned representative selection, shows that factor-balance invariants can fail to distinguish operationally different coordinates, a...

From α,β-Unsaturated Amide to Enamide: Intramolecular Alkene Translocation via Iridium-Catalyzed Transfer Hydrogenation

Abstract Site-selective alkene translocation between two separate segments of a molecule has been a rare and mechanistically intriguing transformation. Herein we report the direct conversion of electrophilic α,β-unsaturated amides to nucleophilic enamides via an Ir-catalyzed alke...

Cotranslational membrane protein biogenesis by an EMC-bound translocon

Secretory and membrane protein biogenesis occurs at ribosome-bound translocons in the endoplasmic reticulum (ER) membrane. Translocons consist of the Sec61 protein-conducting channel and various maturation factors including chaperones, modification enzymes and membrane insertases...

Improving the Timeliness of Test Result Management After Hospital Discharge

BACKGROUND: Failure to follow up on test results pending at discharge (TPAD) is a well-documented patient safety issue, affecting 20% to 61% of hospitalized patients. At our institution, TPAD management practices varied, and no standardized process existed. OBJECTIVE: To increase...

Community Flood Perceptions in the Context of Flood Risk and Flood Hazard Indicators

Abstract Floods have and continue to cause severe damage to property and loss of life globally and in the US. The perceived risk of flooding, defined as an individual’s subjective assessment of the likelihood and severity of a flood event, can influence their preparedness and res...

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Application to Dalhousie University September 2026 : A Quick Note About Information System Classifications

We have started an Application into The Dalhousie University English Program. We notice for the first time a very intelligent information system. Some documents that we did save in our Google Drive Account [but not published elsewhere*] have contributive value in the system. As f...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Discovering how ice crystals grow using neural ODEs and symbolic regression

Depositional ice growth strongly influences the evolution and lifetime of ice-containing clouds on Earth and Mars, yet its physics remain uncertain because the earliest stages of ice-crystal growth cannot be directly observed and are sparsely sampled in laboratory settings. Here,...

Connexin46-enriched extracellular vesicles facilitate cargo delivery and promote angiogenesis

Abstract Extracellular vesicles (EVs) are constantly released from cells. Their contents vary depending on conditions and cell type, influencing their effects on recipient cells. They have been implicated in several diseases, being currently recognized as key mediators of interce...

Deflecting Suicide Calls From Law Enforcement With an Embedded Crisis Line Specialist at a 911 Center: A Synthetic Control Analysis

Law enforcement are the default responders to suicide-related calls, and law enforcement can escalate mental health crises to hospitalizations, uses of force, and deaths. Mental health crisis lines, such as 988, are an alternative underutilized mental health crisis resource compa...

Rule Development in Online Communities Amidst Growth and Generative AI

Online community moderators continually adapt their rules to meet changing realities. The dynamics of these micro-level governance actions reflect various community needs and online moderation strategies. Understanding how online communities adapt their moderation rules as they g...

Method, Mind, and Morality: How People Make Sense of Artificial Intelligence

How can humans make sense of the rapid takeoff of artificial intelligence (AI)? We studied the sensemaking dynamics of AI through an open-ended, mixed-methods study with computational text analysis of millions of AI-related newspaper articles and social media posts grounded in 57...

Coerced Labor, Caste, and Aspirations for Liberty in Early Nineteenth-Century Bengal: Revisiting the Antislavery Debate from South Asia

Abstract This article revisits the debate on the relationship between capitalism and abolition from the perspective of South Asia. It argues that bringing the antislavery debate into conversation with the extensive literature on caste opens up new comparative possibilities. Comme...

The PancreaSure Multianalyte Blood Test Performs Well at Distinguishing Early-Stage Pancreatic Ductal Adenocarcinoma from High-Risk Controls: A Retrospective Secondary Analysis

Background/Objectives: Biomarkers that can facilitate early detection of pancreatic cancer and extend patient survival are a significant unmet need. PancreaSure is a serum biomarker signature that performed well at distinguishing Stage I and II pancreatic ductal adenocarcinoma (P...

N6-Methyladenosine and 5-Methylcytosine Epitranscriptomic Regulation of Male Reproduction and Fertility

Functional spermatozoa production depends on spermatogenesis, a complex developmental process that requires precise regulation of gene expression at multiple levels. Although considerable progress has been made in understanding the transcriptional and epigenetic mechanisms govern...

A Technique for Hardness Amplification Against $$\textsf{AC}^0$$

Abstract To show that a function h is hard to approximate for $$\textsf{AC}^0$$ AC 0 circuits, one method is to (a) design some distribution over random restrictions or random projections, (b) show that $$\textsf{AC}^0$$ AC 0 circuits simplify to shallow decision trees under thes...

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrat...

Reliability of computational versus noncomputational metrics of working memory and episodic memory in serious mental illness.

= 76). These participants were tested in working memory and episodic memory paradigms. We applied a computational model that yielded parameters corresponding to memory storage capacity, memory precision, and the rate of attention lapses. We also examined a noncomputational metric...