University of Chicago

Evaluating Mechanical-EmbeddingML/MM for PredictingMutation Effects in Chorismate Mutase Catalysis

Abstract Predicting how mutations alter enzyme catalysis remains a central challenge in enzymology and enzyme engineering. Although quantum mechanics/molecular mechanics (QM/MM) simulations can in principle compute the activation free energy associated with enzymatic reactions, t...

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

ElectrocatalyticHydrogenation with NanoparticlesDerived from a Cobalt Metal–Organic Framework

Abstract Electrocatalytic hydrogenation (e -H) provides a sustainable route for converting unsaturated organic substrates under mild conditions using renewable electricity as the driving force. Here, we report an MOF-derived cobalt catalyst for the e -H of acetone and pyridine. A...

The Concept of ākupeyar in Tamil Grammar A Historical and Comparative Perspective

This paper traces the history of the concept of the syntactic category ākupeyar ‘referent shifting noun’ in Tamil grammatical tradition and its transformation into a semantic category and the role of Sanskrit grammatical thoughts in the transformation. Theoretically limited numbe...

Desiccation tolerance as a driver of environmental persistence and transmission in nosocomial bacterial pathogens

Hospital-acquired infections (HAIs) represent a major global health burden, leading to increased patient morbidity, mortality, and healthcare costs. These infections frequently occur following patient contact with microbial pathogens persisting on indwelling devices and other abi...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...

Varieties of anti-establishment appeals: valence, ideology, and support for outsiders

Outsider candidates who criticize political elites have surged globally. While most studies treat anti-elite rhetoric as a “thin” ideology, I examine variation in its content. I distinguish between two types of anti-establishment appeals: valence-based appeals, which highlight th...

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay

Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...

Mapping the Korean national R&D system: a capability-based network approach to actor heterogeneity

Abstract This study introduces a capability-based network framework for analyzing actor heterogeneity in the Korean national R&D system. Using project-level data from the National Science and Technology Information System (NTIS)—comprising 63,305 R&D projects conducted by...

The Legitimacy of Popular Domination: Democracy and Puritan Political Theology in the Massachusetts Bay Colony, 1630-1691

This dissertation investigates the issue of the legitimacy of the Massachusetts Bay Colony's social order between 1630 and 1691. Based on archival research, it analyzes the Massachusetts puritans' entangled ideational, institutional, and agentic modes of expression throughout the...

Peritoneal Dialysis Outcomes in Autosomal Dominant Polycystic Kidney Disease

Background: Peritoneal dialysis (PD) is a form of home dialysis that is underutilized in the United States. Patients with autosomal dominant polycystic kidney disease (ADPKD) are frequently good PD candidates who are often young and have few comorbid conditions. However, clinicia...

Novel Placental Functional Capacity Score: A Single Quantitative Score Estimating Placental Function and Its Association with Pregnancy Outcomes

BACKGROUND: Determining placental functional capacity from a typical pathology report can be difficult. Our goal was to create a new way to report on the functional capacity of the placenta, using much of the typical information obtained in a routine placental pathology assessmen...

Implant-Related Complications After Robotic-Assisted Versus Manual Revision Knee Arthroplasty: A Propensity-Matched Cohort Study

INTRODUCTION: As robotic-assisted total knee arthroplasty (TKA) gains traction in revision procedures, the urgent need to investigate its effectiveness compared with manual methods becomes apparent. METHODS: Data were retrospectively obtained from the TriNetX Collaborative Networ...