University of Chicago

Overlapping Schwarz Scheme for Linear-Quadratic Programs in Continuous Time

We present an optimize-then-discretize framework for solving linear-quadratic optimal control problems (OCPs) governed by time-inhomogeneous ordinary differential equations. Our method employs a modified overlapping Schwarz decomposition based on the Pontryagin Minimum Principle,...

Chiral discrimination of amino acids in meteorite and desert soil extracts via single-molecule nanogap conductance

Life on Earth uses L-amino acids and D-sugars, whereas abiotic processes produce equal abundances of both enantiomers. Detecting enantiomeric excess among molecules of biological interest has therefore been proposed as a potential biosignature for life beyond Earth. However, robu...

Establishment of a seedling-based regeneration system for Taiwan oil millet (Eccoilopus formosanus) to support crop domestication and C4 biology

Taiwan oil millet (TOM; Eccoilopus formosanus) is a semi-domesticated orphan crop with potential as a resilient crop species and a model for C4 biology. However, the lack of an efficient tissue culture system has limited its use in genetic and functional studies. In this study, w...

Catalytic Redox-Neutral Decarboxylative Aromatization via Transfer Dehydrogenation

Abstract Arenes are fundamental structural motifs in organic molecules; therefore, methods for introducing aromatic rings are of broad importance. Traditional approaches that install arenes early followed by postfunctionalization sometimes struggle to achieve diverse substitution...

Hostile attribution biases are resistant to manipulations of momentary loneliness.

Loneliness, a perceived discrepancy between desired and actual social relationships, shifts cognition in ways that support heightened sensitivity to potential social threat. These cognitive biases are thought to perpetuate loneliness and subsequent long-term health risk. One such...

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Pilomatrix-like high grade carcinomas involving urinary bladder: a novel divergent differentiation in urothelial carcinoma

Abstract The full morphologic spectrum of divergent differentiations in urothelial carcinoma is still unknown. Herein, we describe two cases of pilomatrix-like high grade carcinomas (PiMLC) involving bladder. Case #1 was a 55-year-old male with a bladder tumor with basaloid nests...

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Robert Marteau and the French Blank Alexandrine

Thanks to the inspiring Three Thousand Years of Hebrews Versification: Essays in Comparative Prosody by Benjamin Harshav (Yale University Press, 2014) and in particular its first chapter, “Basic Aspects of Meter and Rhythm,” it is possible to take a fresh look at the history of F...

The DESI Y1 RR Lyrae Catalog. I. Empirical Modeling of the Cyclic Variation of Spectroscopic Properties and a Chemodynamical Analysis of the Outer Halo

Abstract We present the catalog of RR Lyrae stars (RRLs) observed in the first year of operations of the Dark Energy Spectroscopic Instrument (DESI) survey. This catalog contains 6240 RRLs out to ∼120 kpc from the Galactic center and over 12,000 individual epochs with homogeneous...

Modeling decision dynamics disentangles working memory, cognitive control and reinforcement learning and reveals clinical differences

Various neurocognitive processes contribute to reinforcement learning (RL) and decision making, requiring careful task designs and computational modeling to disentangle them. People rely on capacity-limited working memory (WM) to rapidly and flexibly adapt behavior during learnin...

Towards On-Device Evidence Gathering for Intimate Partner Infiltration: A Feasibility Study for Joint Identity-Action Detection

Intimate Partner Infiltration (IPI) refers to phone-side privacy infiltration in intimate or close relationships, often enabled by physical access to a person's smartphone and discussed in technology-facilitated Intimate Partner Violence (IPV) contexts. Unlike conventional cybera...

A Hybrid Quantum–AI Framework for Protein Structure Prediction on NISQ Devices

Variational quantum algorithms provide a direct, physics-based approach to protein structure prediction, but their accuracy is limited by the coarse resolution of the energy landscapes generated on current noisy devices. We propose a hybrid framework that combines quantum computa...

Agentic AI—Physicist Collaboration in Experimental Particle Physics: A Proof-of-Concept Measurement with LEP Open Data

We present an agentic measurement of the thrust distribution in \(e^+e^-\) collisions at \(\sqrt{s}=91.2\) GeV using ALEPH archived data. This work was carried out through an AI agent–physicist collaboration, using interactive natural-language prompting of Anthropic Claude and Op...

MEGATRON: Reproducing the Diversity of High-Redshift Galaxy Spectra with Cosmological Radiation Hydrodynamics Simulations

We present the MEGATRON suite of cosmological radiation hydrodynamics simulations following the formation of Milky Way-mass galaxies from the earliest cosmic epochs when Population III stars form to Cosmic Noon. The suite represents the first set of cosmological simulations that...

AppetiteCheck: Feasibility of Momentary Vagus Nerve Stimulation as an Implicit Intervention for Eating Behavior

Overeating and emotional eating are common health issues that affect people even without an eating disorder. The vagus nerve plays a critical role in the gut-brain axis, and implanted vagus nerve stimulators have been associated with reduced appetite. In this paper, we propose tr...

From α,β-Unsaturated Amide to Enamide: Intramolecular Alkene Translocation via Iridium-Catalyzed Transfer Hydrogenation

Abstract Site-selective alkene translocation between two separate segments of a molecule has been a rare and mechanistically intriguing transformation. Herein we report the direct conversion of electrophilic α,β-unsaturated amides to nucleophilic enamides via an Ir-catalyzed alke...

Canonicalizing the Wrong Thing: Quotient-Aligned Gauge Fixing for Semantic Representations

This preprint studies when prediction-equivalent representations are interchangeable under a declared downstream interface. It formalizes quotient-aligned representative selection, shows that factor-balance invariants can fail to distinguish operationally different coordinates, a...