University of Chicago

Anatomical versus reverse total shoulder arthroplasty for primary glenohumeral osteoarthritis with an intact rotator cuff

Aims Anatomical total shoulder arthroplasty (aTSA) has been the traditional treatment for glenohumeral osteoarthritis (OA) with an intact rotator cuff. However, reverse total shoulder arthroplasty (rTSA) is now being more frequently performed, with its utility in consistent fixat...

Embracing the Enemy

Abstract A principal (such as a centrist political party) can partially influence the allocation of power between two competing parties. The principal is closer to one party, the ``Friend'', than to the other, the ``Enemy''. The principal's optimal contract initially seeks to exc...

Surgeon Characteristics Associated With Average CPT ® 31237 Utilization per Medicare Beneficiary

Background A retrospective cohort study of 69,170 patients who underwent endoscopic sinus surgery between 2015 and 2022 found that 38.7% of the variation in the number of postoperative debridements was explained at the surgeon level. The extent to which postoperative debridements...

Pedagogy in the speech-gesture couplings of caregivers: Evidence from a corpus-based analysis

In face-to-face communication, representational gestures-imagistically evoking properties of referents-support both language comprehension and development. In adult-adult interaction, representational gestures are systematically produced before the words they are semantically rel...

Near-total loss of buttressing stresses observed on Pine Island Ice Shelf, West Antarctica

Ice shelves, the floating extensions of the Antarctic Ice Sheet, provide critical buttressing stresses that resist the seaward flow of ice and help set the position of the grounding line, where the ice goes afloat. As buttressing stresses are diminished by thinning or fracturing...

Palliative care documentation in gastrointestinal bleeding hospitalizations: national trends and associated care patterns

BACKGROUND: Gastrointestinal bleeding (GIB) often affects older, medically complex patients, yet national patterns of inpatient palliative care documentation in GIB are unknown. We aimed to characterize trends and factors associated with palliative care documentation and examine...

Crosstalk between SELENOF and the unfolded protein response in breast epithelium dictates cell fate

Abstract SELENOF is an understudied selenoprotein that contains selenium in the form of selenocysteine. Our previous findings indicate that SELENOF likely functions as a tumor suppressor in breast cancer; however, its precise molecular role and regulatory mechanisms remain poorly...

The Posterior Scrotal Artery Adipofascial Flap for Rectourethral Fistulae

INTRODUCTION: Acquired rectourethral fistulas (RUF) are uncommon but challenging problems in colorectal and urologic surgery. They are most commonly iatrogenic or secondary to trauma, inflammatory bowel disease, or infection. Standard management consists of colonic diversion, fis...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

Canonicalizing the Wrong Thing: Quotient-Aligned Gauge Fixing for Semantic Representations

Preprint, version 1. Modern predictive models often admit a representation gauge: optimization, normalization, or post-processing may select a stable representative without selecting the distinctions required by downstream use. We formalize quotient alignment: a selection criteri...

Canonicalizing the Wrong Thing: Quotient-Aligned Gauge Fixing for Semantic Representations

Preprint, version 1. Modern predictive models often admit a representation gauge: optimization, normalization, or post-processing may select a stable representative without selecting the distinctions required by downstream use. We formalize quotient alignment: a selection criteri...

Reward selectively preserves relational structure in memory

Memories tend to form networks that reflect relationships between experiences. These networks, or cognitive graphs, have been used to study how structural features of memory can bias decisions — analogous to how reward shapes choices by prioritizing reward-associated items in mem...

Exploration of visual analogue scale versions with the EQ-HWB-9 to measure health, social care, and carer-related quality of life: a VASt landscape

Abstract Purpose Visual analog scales (VAS) serve as brief, informative patient reported outcome measures. The EQ VAS is an important component of EQ-5D instruments but is not currently included in the EQ-HWB-9. This study qualitatively assessed perceptions of alternative VAS con...

Spatial Working Memory Across Psychiatric Disorders in Young Adults

Objective: Impairments in spatial working memory (SWM) have been observed in several disparate psychiatric conditions.The present study investigated how SWM varied across a range of psychiatric disorders in a large sample of young adults using the Spatial Working Memory test from...

A Reproducible Evidence-Audit Framework for Leakage, Feature Stability, and Transportability in Translational Omics Classification

Submission-aligned code, outputs, figures, supplements, and manuscript for a reproducible evidence-audit framework in high-dimensional translational omics classification. A naive global-selection workflow is contrasted descriptively with a guarded nested workflow; because the arm...

A Reproducible Evidence-Audit Framework for Leakage, Feature Stability, and Transportability in Translational Omics Classification

Submission-aligned code, outputs, figures, supplements, and manuscript for a reproducible evidence-audit framework in high-dimensional translational omics classification. A naive global-selection workflow is contrasted descriptively with a guarded nested workflow; because the arm...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Structurally competent care for families facing the continuous traumatic stress of community violence and systemic racism

Abstract In racially and economically segregated communities, structural violence and chronic adversity perpetuate the risk for community violence and related trauma exposure. Despite widespread awareness of community violence, urban youth of color are among those least likely to...

EngineeringIntermediate Phases in Topotactic PhaseTransitions of Cobaltite Perovskites

Abstract Topotactic phase transitions in perovskite cobaltites (R1–xAxCoO3−δ; R = rare earth, A = alkaline-earth ion) play a key role in the operation of neuromorphic devices, where oxygen vacancy concentration (δ) modulates resistive switching. However, the emergence of an insul...

The Search for Life Elsewhere: Avoiding Hype and Fostering Public Understanding

The search for life beyond Earth presents unique challenges for science communication due to its interdisciplinary nature, the potential for groundbreaking discoveries, and the inherent uncertainties involved. The Lorentz Center workshop Breaking News: We Found Extraterrestrial L...