University of Chicago

P1.227. A Composite Body Composition Score Independently Predicts Long-Term Survival After Esophagectomy for Cancer

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Body composition (BC) measures are established determinants of esophageal cancer outcomes. Beyond known survival predictors such as cancer stage and performance status, a com...

P1.233. Impact of Preoperative Frailty on Long-Term Survival Following Esophagectomy for Esophageal Cancer

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophagectomy can provide cure for esophageal cancer yet is associated with high rates of perioperative morbidity. Assessing frailty in the preoperative setting provides supe...

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Existence of minimal surfaces in infinite-volume hyperbolic 3-manifolds

Abstract The existence of embedded minimal surfaces in non-compact 3-manifolds remains a largely unresolved and challenging problem in geometry. In this paper, we address several open cases regarding the existence of finite-area, embedded, complete, minimal surfaces in infinite-v...

Tele-Robotic Surgery for Combat Casualty Care

Objective: These experiments test the feasibility of tele-robotic surgery for the shipboard care of combat casualties. Summary Background Data: Limited research on the effects of telecommunications latency on tele-robotics has been a consistent concern in the growth of tele-robot...

Initiation of rotational collective migration in Drosophila through tissue geometry and mechanochemical feedback

Collective migration of epithelial cells drives diverse tissue remodeling processes. In many cases, a free tissue edge works alone or in combination with other external cues to align the cells for collective movement, but how edge-free or closed epithelia become polarized for dir...

Functional Multireference Alignment via Deconvolution

Abstract. This paper studies the multireference alignment (MRA) problem of estimating a signal function from shifted, noisy observations. Our functional formulation reveals a new connection between MRA and deconvolution: the signal can be estimated from second-order statistics vi...

Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions.

T cell infiltration and reduces T cell activation and proliferation; and iii) therapeutic strategies, including D-1MT, that improve intragranulomatous killing hold strong translational potential.

Constraints on Large-Scale White Noise in the Cosmic Density Field

We present observational constraints on large-scale white noise (LSWN) in the cosmic density field, a phenomenon predicted to arise from nonlinear mode coupling during cosmological evolution. Building on the theoretical framework of our companion paper, where we demonstrated that...

History of divergence and gene flow shaping geographic variation in Andean warblers (Myioborus).

Studying how genetic variation is structured across space, and how it relates to divergence in phenotypic traits relevant to reproductive isolation, is important for our understanding of the speciation process. We used ddRAD-seq data to examine genetic variation across the distri...

Profiling maize embryonic leaf development and discovering new genes using high-resolution spatial long-read isoform sequencing

Abstract Profiling transcriptome isoforms in their spatial context is instrumental for deciphering plant embryogenesis. By combining high-throughput full-length isoform sequencing and spatial transcriptomics (spatial MAS-IsoSeq) in maize embryogenesis, we identified 285,639 isofo...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

Efficacy and Safety of Time-Restricted Eating in Adults With Type 1 Diabetes: A Randomized Controlled Trial

OBJECTIVE: Many adults with type 1 diabetes (T1D) have overweight or obesity, underscoring the need for effective dietary weight loss strategies in this population. Time-restricted eating (TRE) has emerged as a popular approach for weight loss; however, its efficacy and safety in...

Enhancement of cytokine-mediated beta-cell apoptosis by free fatty acids

Type 1 diabetes (T1D) results from dysfunction and loss of the insulin-producing pancreatic β cells. The body’s lipid metabolism is strongly regulated during this process but there is a need to understand how this regulation contributes to the β-cell death. Here, we investigated...

An engineered Clostridial mini consortium modulates intestinal inflammation

Modern lifestyle factors have altered gut microbiota composition and function. Bacteria in the Clostridia class modulate mucosal immune responses through various mechanisms including production of secondary bile acids (SBA). Here, we present a novel system to study how the SBA is...

Structure and Dynamicsof the HIV-1 EnvelopeProtein on the Virion Envelope

HIV-1 buds from infected cells as immature virion particles with a scattered envelope glycoprotein (Env) distribution on their envelope. It then undergoes maturation, during which the viral protease cleaves the Gag polyprotein at multiple sites, leading to structural reorganizati...

Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR

Adhesion G protein–coupled receptors (aGPCRs) transduce signals via engagement of their large extracellular regions (ECRs) with adhesion partners. ADGRG6 (GPR126) is an aGPCR vital for the development of multiple organs and myelination. ECR conformational dynamics of ADGRG6 has b...

Error Estimates of an Exponential Wave Integrator for the Nonlinear Schrödinger Equation with Singular Potential

Abstract. In this paper we analyze a first-order exponential wave integrator (EWI) for the nonlinear Schrödinger equation (NLSE) with a singular potential that is locally in [Formula: see text], which might be locally unbounded. A typical example is the inverse power potential su...

Quantitative computed tomography improves prediction of survival across ILD subtypes

Background Quantitative computed tomography (CT) methods are recognized as valuable tools for risk stratification in fibrotic interstitial lung disease (ILD). Data-driven textural analysis (DTA) is one such approach that correlates with worse lung function and shorter survival in...

Configuring the Geography of Social Service Provision: Neighborhood Characteristics, Nonprofit Spatial Strategies, and Public Funding

Social services in the United States are delivered jointly by government and nonprofits. Prior research examines either the location or the resources of nonprofits; it rarely examines how these factors jointly influence social service availability or access. We leverage a unique...