University of Bonn

Medial Axis Aware Learning of Signed Distance Functions

Abstract We propose a novel variational method to compute a highly accurate global signed distance function (SDF) to a given point cloud. To this end, the jump set of the gradient of the SDF, which coincides with the medial axis of the surface, is explicitly taken into account th...

The parameter estimation tables (PEtab) format version 2

Abstract Parameter estimation is a central task in data-driven computational modeling, and a clear, unambiguous, and commonly understood specification of parameter estimation problems is essential for reproducibility and interoperability. PEtab provides a standardized framework f...

Stand structural differences along a degradation gradient in the National forest inventory of Georgia

Abstract Forest degradation assessments grounded in measurable structural indicators provide a more reproducible basis for management decisions than qualitative field classifications alone, particularly in ecologically diverse forest systems. Based on data from the first National...

An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation

CDC42 is an evolutionarily conserved guanosine triphosphatase (GTPase) regulating critical cellular and immune processes. Variants in CDC42 therefore cause a spectrum of developmental phenotypes, including hematological and immunological symptoms. Here, we identify a previously u...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Platelets as regulators of anti-tumor immunity: mechanisms and clinical implications

Platelets are increasingly recognized as important contributors to tumor progression and metastatic dissemination. Platelets facilitate cancer cell survival, their safe transit through the hostile bloodstream, arrest at distant organ sites, and ultimate outgrowth into metastatic...

Toward Personalized Regenerative Therapies for Parkinson's Disease

Parkinson's disease (PD) represents one of the most common neurodegenerative disorders, significantly impacting the quality of life of millions of people worldwide, and posing growing challenges for healthcare systems. Driven by demographic shifts and increasing numbers of patien...

EFECT enables reliable and reproducible stochastic simulations across disciplines

Stochastic simulations underpin computational research in fields from systems biology and epidemiology to finance and physics-informed machine learning, yet their reproducibility is hard to quantify because each run yields different outcomes. Existing practices to improve computa...

Genotype-dependent growth promotion by Kribbella and Nocardioides in maize under low-phosphorus conditions

Abstract Background and Aims Phosphorus (P) deficiency limits crop productivity. Root hairs are crucial for P acquisition and may influence plant–microbe interactions. We investigated how root-hair defects affect plant responsiveness to beneficial bacteria under low-P conditions,...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Analysing the Evolution of Kenya’s Road Network since the 1950s using Historical andContemporary Road Datasets

Abstract. Kenya’s road network has undergone substantial but uneven transformation since the 1950s. This study compares historical road data derived from topographic maps using a deep learning-based extraction method with contemporary datasets from the Kenya Roads Board, in order...

The Crystal Structures of High‐ and Low‐Temperature Silver Pyrophosphate: Structural Instability and Its Consequences

The crystal structures of the low‐temperature (LT) and high‐temperature (HT) modifications of silver pyrophosphate, Ag 4 P 2 O 7 , were determined from single‐crystal X‐ray data. Thermal analysis, vibrational and 31 P‐MAS‐NMR spectroscopy studies, and density functional theory ca...

How Identity-Specific Workplace Support and Authenticity Drive Individual Entrepreneurial Orientation: Evidence From Sexual and Gender Minoritized Employees

Research on individual entrepreneurial orientation (Ind.EO) has yet to reveal the psychological conditions under which employees demonstrate Ind.EO in the workplace. Addressing this gap, we theorize that authenticity is a crucial mechanism linking identity-specific support to Ind...