University of Bonn

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

Gustatory and olfactory dysfunctions in ALS-patients

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterised by progressive loss of motor function due to cell death of upper as well as lower motor neurons, resulting ultimately in death due to ventilatory and respiratory insufficiency. Due to lac...

Non-Abelian Amplification and Bilinear Forms with Kloosterman Sums

Abstract We introduce a new method to bound bilinear (Type II) sums of Kloosterman sums with composite moduli $c$ c , using Fourier analysis on $\mathrm{SL}_{2}(\mathbb{Z}/c\mathbb{Z})$ SL 2 ( Z / c Z ) and an amplification argument with non-abelian characters. For sums of length...

ALKBH10B mediated epitranscriptomic regulation enhances drought tolerance of Arabidopsis thaliana via hormonal cross-talk and sustained photosynthesis

Abstract Key message The m⁶A demethylase ALKBH10B emerges as a crucial post-transcriptional regulator of hormonal crosstalk, photosynthetic maintenance, and mitochondrial energy metabolism to fine-tune plant stress adaptation to drought . Abstract Epitranscriptomic N⁶-methyladeno...

Rapid Two-StepMulticomponent Synthesis and Structure-degradationRelationships of Selective HDAC6 PROTAC Degraders

Abstract This work reports on the development of selective histone deacetylase 6 (HDAC6) degraders based on a peptoid scaffold. Structure-based design identified the isocyanide-derived cap region as suitable exit vector for linker attachment, enabling rapid generation of CRBN-rec...

Predicting Brain Function from Structure with MRI and Supervised Machine Learning

The main goal of this thesis is to develop machine learning based tools that can be used to investigate the relationship between brain structure, with a focus on white matter tracts, and function. In particular, this work introduces novel methodologies that enhance our ability to...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

CCR7-Mediated Dendritic Cell Migration: A Multilevel Analysis of Metabolic and Regulatory Mechanisms

Regulated cellular motility is a defining characteristic of immune cell functionality, which necessitates the intricate coordination of the actin cytoskeleton, metabolic dynamics, and the expression of cell surface receptors. While the cytoskeletal role has been extensively chara...

Chemically InterpretableExplanations for MolecularProperty Prediction via Fragment-Level Shapley Values

Abstract Machine learning has emerged as a powerful approach for molecular property prediction and drug discovery. However, the black-box nature of many machine learning models limits their interpretability, trustworthiness, and adoption in interdisciplinary research settings. Th...

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Microglia are innate immune cells of the central nervous system (CNS). They extend their processes and migrate toward injuries in vivo. However, how the fractalkine receptor (CX3CR1) influences microglial migration remains unknown. Label-free proteomic profiling predicted changes...

A cross-cultural survey of Indigenous views on interspecies communication – Towards a consilience with scientific knowledge

Communication serves as a pivotal means for mutual understanding beyond species boundaries. Definitions of interspecific communication – particularly between humans and non-human organisms – vary not only across research disciplines, but also across cultures and societies driven...

TLR2 mediates cell cycle re-entry and survival of neonatal cardiomyocytes in response to injury

Abstract Unlike adult hearts, neonatal hearts can regenerate and adapt to stress. To identify both cardioprotective and regenerative mechanisms, we compared activated genes and related signaling pathways in the neonatal mouse heart after myocardial infarction (MI) and after expos...

The parameter estimation tables (PEtab) format version 2

Abstract Parameter estimation is a central task in data-driven computational modeling, and a clear, unambiguous, and commonly understood specification of parameter estimation problems is essential for reproducibility and interoperability. PEtab provides a standardized framework f...

Medial Axis Aware Learning of Signed Distance Functions

Abstract We propose a novel variational method to compute a highly accurate global signed distance function (SDF) to a given point cloud. To this end, the jump set of the gradient of the SDF, which coincides with the medial axis of the surface, is explicitly taken into account th...

Stand structural differences along a degradation gradient in the National forest inventory of Georgia

Abstract Forest degradation assessments grounded in measurable structural indicators provide a more reproducible basis for management decisions than qualitative field classifications alone, particularly in ecologically diverse forest systems. Based on data from the first National...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation

CDC42 is an evolutionarily conserved guanosine triphosphatase (GTPase) regulating critical cellular and immune processes. Variants in CDC42 therefore cause a spectrum of developmental phenotypes, including hematological and immunological symptoms. Here, we identify a previously u...

EFECT enables reliable and reproducible stochastic simulations across disciplines

Stochastic simulations underpin computational research in fields from systems biology and epidemiology to finance and physics-informed machine learning, yet their reproducibility is hard to quantify because each run yields different outcomes. Existing practices to improve computa...

Platelets as regulators of anti-tumor immunity: mechanisms and clinical implications

Platelets are increasingly recognized as important contributors to tumor progression and metastatic dissemination. Platelets facilitate cancer cell survival, their safe transit through the hostile bloodstream, arrest at distant organ sites, and ultimate outgrowth into metastatic...

Toward Personalized Regenerative Therapies for Parkinson's Disease

Parkinson's disease (PD) represents one of the most common neurodegenerative disorders, significantly impacting the quality of life of millions of people worldwide, and posing growing challenges for healthcare systems. Driven by demographic shifts and increasing numbers of patien...