University of Bonn

Algorithm Aversion Towards AI-Generated Multiple-Choice Questions

Abstract Algorithm aversion and anti-AI bias describe the human tendency to evaluate decisions made by human agents more favorably than those made by artificial intelligence (AI) algorithms. This study aimed to examine whether algorithm aversion influences students’ evaluations o...

A Peter–Weyl theorem for compact group bundles and the geometric representation of relatively ergodic compact extensions

We show that a relatively ergodic extension of measure-preserving dynamical systems has relative discrete spectrum if and only if it can be represented as a skew-product by a bundle of compact homogeneous spaces. Our result holds without restrictions on the acting group or the un...

Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care

Abstract Chronic pelvic pain syndrome (CPPS) encompasses a heterogeneous group of debilitating conditions including interstitial cystitis/bladder pain syndrome (IC/BPS), chronic abacterial prostatitis, endometriosis, and pelvic congestion syndrome, among others. Despite advances...

Legacy effects of subsoil compaction and earthworm biopores on soil hydrophysical properties and root density in a temperate silt loam soil

The short- and medium-term effects of agricultural soil compaction are well documented, but its long-term impacts and the role of biopores in subsoil recovery remain poorly understood. This study evaluated legacy effects of subsoil compaction on soil hydrophysical properties and...

MEmilio: a high performance Modular EpideMIcs simuLatIOn software for multi-scale and comparative simulations of infectious disease dynamics

Abstract Epidemic and pandemic preparedness with rapid outbreak response rely on timely, trustworthy evidence. Mathematical models are crucial for supporting timely and reliable evidence generation for public health decision-making with models spanning approaches from compartment...

A Radio-Frequency Ion Trap for Quantum Information Science with Yb+ Ions

In this thesis, the next generation of the ion trapping setup has been designed, constructed, and successfully implemented for studying quantum information science at the University of Bonn. The new setup is designed to include an optical cavity as the endcap electrodes of a line...

Observation of critical scaling in the Bose gas universality class

Critical exponents characterize the divergent scaling of thermodynamic quantities near phase transitions and allow for the classification of physical systems into universality classes. While quantum gases thermalizing by interparticle interactions fall into the XY model universal...

The Space of Desire

The philosophical and theological hermeneutics in Meister Eckhart’s German sermons offer an interesting framework for reflecting on personal formation in education today. His ideas on identity, language, ethics, work, and trust open a “space for desire” that goes beyond academic...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

ALKBH10B mediated epitranscriptomic regulation enhances drought tolerance of Arabidopsis thaliana via hormonal cross-talk and sustained photosynthesis

Abstract Key message The m⁶A demethylase ALKBH10B emerges as a crucial post-transcriptional regulator of hormonal crosstalk, photosynthetic maintenance, and mitochondrial energy metabolism to fine-tune plant stress adaptation to drought . Abstract Epitranscriptomic N⁶-methyladeno...

Non-Abelian Amplification and Bilinear Forms with Kloosterman Sums

Abstract We introduce a new method to bound bilinear (Type II) sums of Kloosterman sums with composite moduli $c$ c , using Fourier analysis on $\mathrm{SL}_{2}(\mathbb{Z}/c\mathbb{Z})$ SL 2 ( Z / c Z ) and an amplification argument with non-abelian characters. For sums of length...

Gustatory and olfactory dysfunctions in ALS-patients

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterised by progressive loss of motor function due to cell death of upper as well as lower motor neurons, resulting ultimately in death due to ventilatory and respiratory insufficiency. Due to lac...

Rapid Two-StepMulticomponent Synthesis and Structure-degradationRelationships of Selective HDAC6 PROTAC Degraders

Abstract This work reports on the development of selective histone deacetylase 6 (HDAC6) degraders based on a peptoid scaffold. Structure-based design identified the isocyanide-derived cap region as suitable exit vector for linker attachment, enabling rapid generation of CRBN-rec...

Predicting Brain Function from Structure with MRI and Supervised Machine Learning

The main goal of this thesis is to develop machine learning based tools that can be used to investigate the relationship between brain structure, with a focus on white matter tracts, and function. In particular, this work introduces novel methodologies that enhance our ability to...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

CCR7-Mediated Dendritic Cell Migration: A Multilevel Analysis of Metabolic and Regulatory Mechanisms

Regulated cellular motility is a defining characteristic of immune cell functionality, which necessitates the intricate coordination of the actin cytoskeleton, metabolic dynamics, and the expression of cell surface receptors. While the cytoskeletal role has been extensively chara...

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Microglia are innate immune cells of the central nervous system (CNS). They extend their processes and migrate toward injuries in vivo. However, how the fractalkine receptor (CX3CR1) influences microglial migration remains unknown. Label-free proteomic profiling predicted changes...

Chemically InterpretableExplanations for MolecularProperty Prediction via Fragment-Level Shapley Values

Abstract Machine learning has emerged as a powerful approach for molecular property prediction and drug discovery. However, the black-box nature of many machine learning models limits their interpretability, trustworthiness, and adoption in interdisciplinary research settings. Th...

TLR2 mediates cell cycle re-entry and survival of neonatal cardiomyocytes in response to injury

Abstract Unlike adult hearts, neonatal hearts can regenerate and adapt to stress. To identify both cardioprotective and regenerative mechanisms, we compared activated genes and related signaling pathways in the neonatal mouse heart after myocardial infarction (MI) and after expos...

A cross-cultural survey of Indigenous views on interspecies communication – Towards a consilience with scientific knowledge

Communication serves as a pivotal means for mutual understanding beyond species boundaries. Definitions of interspecific communication – particularly between humans and non-human organisms – vary not only across research disciplines, but also across cultures and societies driven...