University of Basel

MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography

Abstract Cryo-electron tomography provides unique insights into macromolecular complexes in their native environments, yet membrane analysis remains a major bottleneck due to low signal-to-noise ratios, missing wedge artifacts and the complexity of membrane-associated particles....

Genomic insights into the evolutionary dynamics of Phytophthora infestans lineages after the Irish Potato Famine

Abstract Background Genomic analysis of infected herbarium specimens provides the opportunity to investigate the evolutionary history of plant pathogens, leading to discoveries such as the identification of FAM-1/HERB-1 as the Phytophthora infestans lineage that caused the ninete...

Placenta–Brain Axis Under Heat Stress: Inflammatory Pathways Linking Prenatal Thermal Exposure to Offspring Neurodevelopment

Climate change is increasing the frequency and intensity of extreme heat events, raising concern about prenatal thermal exposure as a potential risk factor for fetal brain development and offspring neurodevelopment. This systematic review aimed to synthesize evidence on prenatal...

Ternary Neurexin-T178-PTPR complexes represent a pre-synaptic core-module of neuronal synapse organization

Abstract Synapses, prototypic sites for neuronal communication, are key to brain function. Their organization and properties are instructed by synaptic cell adhesion molecules (sCAMs) that may operate independently or in coordination through yet unknown linker proteins. Here, we...

eGDR and gastrointestinal cancer mortality in the UK Biobank: a prospective cohort study

Abstract Background This study examined the associations of estimated glucose disposal rate (eGDR), a surrogate of insulin sensitivity, and the insulin resistance indices TG/HDL-C and TyG with gastrointestinal (GI) cancer mortality in the UK Biobank. Methods We included 369,447 p...

Awareness and management of post-bariatric hypoglycemia: an international survey of healthcare professionals

Abstract Postprandial hypoglycemia (PBH) is a recognized complication following bariatric surgery, but real-world data on its management by healthcare professionals (HCPs) is lacking. To address this, a 25-item multilingual questionnaire was developed and distributed online to HC...

Exploring Differential Item Functioning through Machine Learning: A Review of Rasch Trees and Regularized Moderated Rasch Models

Detecting and interpreting differential item functioning (DIF) is critical for ensuring the fairness and validity of measurement instruments. Combinations of psychometric models with data-driven machine learning (ML) approaches have been introduced to facilitate comprehensive DIF...

Sex-specific control of locomotor behavior by neuronal Arhgef10 in aged Drosophila

Mutations and polymorphisms in the Rho guanine nucleotide exchange factor 10 (ARHGEF10) locus are associated with behavioral and locomotor dysfunctions in humans, including psychiatric disorders and polyneuropathies that show age- and sex-specific prevalence. ARHGEF10 encodes a c...

Adverse health outcomes across the life course in individuals with six rare bone diseases: a 10-year population-based cohort study

Abstract Background Rare bone diseases comprise a heterogeneous group of complex and disabling conditions. Evidence on age-specific hospitalization patterns and in-hospital outcomes across multiple rare bone diseases is limited. Methods Population-based cohort study using nationa...

Diagnostic performance of Baermann technique, urine-ELISA, stool-PCR and Strongyloides IgG4 rapid test for diagnosis of strongyloidiasis: a study protocol

Strongyloidiasis is caused by a parasitic worm, primarily Strongyloides stercoralis . In rural settings of Côte d’Ivoire, parasitological surveys have revealed that the prevalence of S. stercoralis infection can reach up to 50%. The World Health Organization has included S. sterc...

Virtues and Narratives in Medicine: An Analysis and Collection of Virtue-Illustrating Stories in Medical Journals

This paper draws from a framework of virtue ethics and narrative medicine to present a content analysis and teaching resource of virtue-illustrating stories found in medical journals. As acquired dispositions, virtues are cultivated not merely by listening to lectures but through...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Regulation of Type VI Secretion Systems of Burkholderia during transition to intracellular lifestyle

Abstract Pathogenic bacteria tightly regulate gene expression in response to environmental cues. In Burkholderia species, the Type VI Secretion Systems (T6SS) mediate interbacterial competition and host cell interactions. Here, we show that B. thailandensis switches from the anti...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation

Importance: Pulmonary vein isolation (PVI) is less effective in persistent than in paroxysmal atrial fibrillation (AF). Objective: To determine whether adding posterior left atrial wall isolation (PWI) to pulsed field ablation (PFA)-based PVI reduces atrial tachyarrhythmia in pat...

Connections: A Smarter Way to Target Influencers

Jacob Goldenberg, Andreas Lanz, Florian Stahl, and Daniel Shapira show that managers and creators who build ties with nearby, low-status influencers outperform those who cultivate high-status influencers. This efficient means of expanding audiences uses the existing dynamics of s...

Multiplicative irreducibility of shifted multiplicative subgroups

Abstract In a recent breakthrough, Kalmynin resolved conjectures of Lev–Sonn and Sárközy on additive decompositions of multiplicative subgroups of prime fields. In this paper, inspired by a related conjecture of Sárközy, we prove multiplicative analogues of Kalmynin's results. We...

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The re...

The relative Manin–Mumford conjecture

Abstract We prove the Relative Manin–Mumford Conjecture for families of abelian varieties in characteristic 0. We follow the Pila–Zannier method to study special point problems, and we use the Betti map which goes back to work of Masser and Zannier in the case of curves. The key...

Radiocarbon in atmospheric CH 4 and CO 2 at Jungfraujoch in 2019–2024: influence of regional nuclear emissions and current global atmospheric 14 CH 4 signal

Abstract. Radiocarbon (14C) is a valuable tracer to determine the relative fossil fractions of emitted carbonaceous greenhouse gases, such as CO2 and CH4. While atmospheric ∆14CO2 measurements have been conducted at multiple sites for several decades, ∆14CH4 measurements remain m...