University of Basel

Retinalysis-Vascx: An Explainable Software Toolbox for the Extraction of Retinal Vascular Biomarkers From Color Fundus Images

Purpose: Automatic extraction of retinal vascular biomarkers from color fundus images (CFIs) is crucial for large-scale studies of the retinal vasculature. We present VascX, an open-source software toolbox that extracts biomarkers from CFI artery-vein segmentations. Methods: From...

Comparative cost analysis of community-based tuberculosis screening: Computer-Aided Detection (CAD) alone versus CAD with point-of-care C-reactive protein testing in South Africa and Lesotho

Community-based active case finding (ACF) for tuberculosis (TB) is recommended in high-burden settings, yet evidence on implementation costs from prospective programmatic data remains limited. We estimated and compared the costs of two community-based ACF screening approaches: Co...

The Social Cost of Inequality: Financial Ostracism Experiences Lower Satisfaction with the National Economy Across Eleven Countries

Data analysis scripts and Gini coefficients for "The social cost of inequality: Financial ostracism experiences lower satisfaction with the national economy across eleven countries", published in The Journal of Social Psychology.

Incidence and Risk Factors of Late‐Onset Hypoglycemia in Extremely Low Gestational Age or Extremely Low Birth Weight Infants

ABSTRACT Aim To determine incidence and risk factors associated with late‐onset hypoglycemia in extremely preterm or extremely low birth weight infants. Methods Retrospective single‐center cohort study including infants with a gestational age < 28 weeks or birth weight < 1000 g....

Adolescents’ help-seeking intentions for mental health problems: a mixed-methods study of attitudes and barriers

Abstract Background Adolescents frequently experience mental health problems, yet many do not receive professional support, highlighting the need to understand their attitudes, barriers, and help-seeking intentions. Existing work has rarely combined mixed-method approaches using...

Exploring patients' and family members’ perspectives on intensive care unit experiences through unsolicited feedback: A qualitative content analysis

Background Intensive care unit (ICU) stays are profound and distressing experiences for critically ill patients and their family members, often resulting in physical, psychological, cognitive, and social sequelae. Existing knowledge stems largely from structured interviews or que...

FOXC1 and its lncRNA FOXCUT link DNA methylation to a chondrocyte phenotype dysfunction

Abstract Objective With current osteoarthritis (OA) therapies limited to symptom management, understanding molecular drivers of disease progression is critical. As epigenetic mechanisms increasingly appear central to OA pathogenesis, this study aimed to identify epigenetically dy...

High-density mapping of his-ventricular intervals: impact of recording site and sex-specific differences

Abstract Background Accurate assessment of the His–ventricular (HV) interval is essential to diagnosing infranodal conduction disease, but the influence of recording site and sex on HV values is not well defined. Objective To evaluate the impact of measurement location and sex on...

A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins

J-domain proteins (JDPs) direct Hsp70 functions through a conserved J-domain that engages and activates Hsp70. JDPs support proteostasis and are linked to development and disease, yet how they are regulated remains unclear. Here, we identify a conserved tyrosine motif outside the...

Epistasis and the changing fitness landscapes of SARS-CoV-2

Abstract Since its emergence in late 2019, millions of SARS-CoV-2 genomes have been generated as part of global efforts to monitor the evolution and spread of the virus. This unprecedented volume of data provides a unique opportunity to study viral evolution at unparalleled resol...

Using social dimensions to inform the development of engagement tools for energy communities

The development of digital tools for energy communities is crucial as these can play a significant role increasing efficiency and leading to less grid congestion. However, these tools frequently suffer from a disconnect between technical design and end-user social contexts, leadi...

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

Dimensional accuracy and flexural strength of 3D-printed photopolymer resins for point-of-care surgical guides after steam and plasma sterilization: an in-vitro comparative study

Abstract Background Three-dimensional (3D) printing enables the fabrication of patient-specific guides (PSGs) for oral and craniomaxillofacial procedures. Before clinical use, guides must be sterilized, which may compromise dimensional accuracy and mechanical performance. The eff...

Left atrial anatomy and atrial arrhythmia recurrence after pulsed-field ablation

Abstract Background The impact of left atrial (LA) anatomical features on atrial arrhythmia (AA) recurrence after pulsed-field (PF)-based pulmonary vein isolation (PVI) is unknown. This study aimed to assess LA anatomical features associated with long-term AA recurrence after PVI...

210Pbex in lacustrine sediments: A half-century global synthesis (1977-2024)

Unsupported 210 Pb ( 210 Pb ex ) is a naturally occurring radionuclide widely used to establish sediment chronologies spanning the past ∼150 years, thereby providing high-resolution temporal frameworks for palaeolimnological reconstructions. Since the late 1970s, numerous hypothe...

Not all previous surgeries are the same: Procedure‐specific infection risk in total knee arthroplasty patients with a history of previous knee surgery

Abstract Purpose While patient‐level factors for prosthetic joint infections (PJIs) following total knee arthroplasty (TKA) are well‐established, prior ipsilateral knee procedures are typically treated as a uniform risk factor despite likely variation in risk profile across proce...

Hairy Roots Cultures from the Slow-Growing and Protected Panax ginseng, Leontopodium alpinum and Gynostemma pentaphyllum as an Alternative Source of Antimicrobials

Background/Objectives: Although the potential of hairy roots in secondary metabolite including antimicrobal production has been demonstrated in many laboratories, the scale-up to industrial production might lead to undesired phenomena affecting the final products. Methods: Here,...

Postmortem dental health in a Swiss population: a 10-year retrospective cross-sectional computed tomography study

Abstract Background Population-based studies have reported improved oral health and tooth retention in Switzerland over recent decades, yet little is known about dental status at the end of life and how it can be assessed using postmortem imaging. This study used postmortem compu...

CAF-mediated immune exclusion in osteosarcoma: mechanisms, translational vulnerabilities, and therapeutic strategies

Abstract Background Osteosarcoma remains a highly aggressive bone malignancy with limited therapeutic progress in metastatic and treatment-refractory disease. Beyond tumor-intrinsic drivers, the tumor microenvironment has emerged as a critical determinant of immune escape, therap...

Exploring heterogeneity in mosquito exposure and attraction and its implications for malaria transmission

Abstract Background Malaria transmission exhibits significant heterogeneity within communities, with small proportions of individuals experiencing disproportionate mosquito exposure. Methods This study addresses critical knowledge gaps in characterising and modelling this heterog...