University of Basel

Large transgene arrays cause aberrant transcription and synthetic molting defects

Abstract Multicopy transgene arrays remain widely used in Caenorhabditis elegans research. It is usually assumed that they behave neutrally, not impacting the phenotype under investigation. Here, we reveal that a previously reported heterochronic extra-molt phenotype associated w...

Associating Mycobacterium tuberculosis genomic variants with minimum inhibitory concentrations to delamanid and pretomanid

Emerging resistance to delamanid (DLM) and pretomanid (Pa) threatens drug-resistant tuberculosis (DR-TB) treatment outcomes. The lack of rapid molecular diagnostics, due to limited knowledge of resistance-conferring mutations, along with standardization challenges for critical co...

Perioperative and Periinterventional Platelet Function Testing

Abstract Purpose of the Review This review summarizes the current knowledge on the use of perioperative and periinterventional platelet function monitoring aiming to individualize antiplatelet therapy. Recent Findings In cardiac surgery, the recent guidelines recommend drug-speci...

Learning curves in robotic and laparoscopic colorectal surgery: a systematic review

Abstract Objective To evaluate and compare learning-curve assessment in laparoscopic and robotic colorectal surgery and to develop a standardized framework for future learning-curve reporting. Background Learning curves in minimally invasive colorectal surgery are widely reported...

Steric Stabilization of Lipid Nanoparticles by Sequence-Defined Polymer−Lipids Enhances Gene Expression

Abstract Polyethylene glycol (PEG) conjugated lipids are frequently used for the design of lipid nanoparticles (LNPs) in the field of gene therapy. However, conventional PEG−lipids contain a distribution of polymer chain lengths. To overcome this limitation, we have prepared a st...

Multi-Field CEST NMR Reconstructs a Protein Folding Landscape

Abstract Protein dynamics are central to their folding and function, yet the sparsely populated conformational states that underpin these processes remain difficult to characterize at atomic resolution. Chemical exchange saturation transfer (CEST) NMR can detect such states and i...

Nucleosynthesis in the fast ejecta of a neutron star merger

Abstract Neutron star mergers are today considered a major production site for rapid neutron capture elements. While the bulk of the matter escapes at fast, but non-relativistic velocities (~0.2 c), a small amount of the dynamically ejected mass reaches mildly relativistic veloci...

Can Intraoperative Therapeutic Window Data Predict Chronic Contact Selection in Deep Brain Stimulation?

Abstract Deep brain stimulation (DBS) programming relies on selecting electrode contacts that maximize clinical benefit while minimizing side effects. The therapeutic window (range of current yielding symptom improvement without adverse effects) is a key criterion in this decisio...

Occupational heat strain among home health care workers: a cross-sectional study

Abstract Background Extreme heat events affect workers’ health. Home health care workers face physically strenuous tasks, mobility demands, and increased workloads during heat events. Yet little is known about the extent of heat strain and the specific symptoms they experience. T...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Best Practices in Nanocrystal Synthesis and Characterization

Conspectus Colloidal nanocrystals exhibit quantum-mechanical phenomena inaccessible in bulk matter, and their properties can be tuned via chemically manipulating their composition, size, shape, and surface chemistry. Decades of development have produced a remarkable synthetic lib...

Robotic versus open mesh-enforced retrorectus ventral hernia repair: a multi-center comparative study

Abstract Mesh-enforced open ventral hernia repair (OVHR) is associated with increased surgical site occurrences and prolonged hospital stay. Robotic-assisted ventral hernia repair (RVHR) may offer benefits compared to OVHR, but comparative literature is scarce. This multicenter p...

Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ

Abstract The arms race of bacteriophages and their bacterial hosts has inspired major breakthroughs in biotechnology and shaped phages as fierce predators with great clinical potential to fight multidrug-resistant bacterial pathogens. However, the large amount of genes of unknown...

Mercury cycling during the last glacial period in Arctic Lake El'gygytgyn, NE Russia

ABSTRACT Tectonic processes play a key role in the global mercury (Hg) cycle on geological timescales, by mobilising Hg from deep Earth reservoirs to the surface. These natural fluxes also introduce a dynamic component to the terrestrial Hg cycle that can interact with other envi...

Full-Dimensional Reactive Potential Energy Surfaces of OCS+ for S+ Dissociation: Ground and Excited States

Abstract Full-dimensional reactive potential energy surfaces (PESs) for the OCS+ cation are constructed to describe S+ loss in the electronic ground state and seven low-lying electronically excited states. High-level ab initio reference energies were computed at the MRCI+Q/aug-cc...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer

Breast cancer progression to visceral organs such as the lung and liver is associated with poor prognosis. Yet, these organs have diverse cellular microenvironments that may differentially influence cancer cell behavior. Here, we show that breast cancer metastases differ in their...

Comparative cost analysis of community-based tuberculosis screening: Computer-Aided Detection (CAD) alone versus CAD with point-of-care C-reactive protein testing in South Africa and Lesotho

Community-based active case finding (ACF) for tuberculosis (TB) is recommended in high-burden settings, yet evidence on implementation costs from prospective programmatic data remains limited. We estimated and compared the costs of two community-based ACF screening approaches: Co...

Retinalysis-Vascx: An Explainable Software Toolbox for the Extraction of Retinal Vascular Biomarkers From Color Fundus Images

Purpose: Automatic extraction of retinal vascular biomarkers from color fundus images (CFIs) is crucial for large-scale studies of the retinal vasculature. We present VascX, an open-source software toolbox that extracts biomarkers from CFI artery-vein segmentations. Methods: From...

The Social Cost of Inequality: Financial Ostracism Experiences Lower Satisfaction with the National Economy Across Eleven Countries

Data analysis scripts and Gini coefficients for "The social cost of inequality: Financial ostracism experiences lower satisfaction with the national economy across eleven countries", published in The Journal of Social Psychology.