University of Alberta

Tree-based structural equation model for assessing measurement invariance in patient-reported outcome measures

Evidence of measurement invariance (MI) is essential to ensure that scores based on patient-reported outcome measures (PROMs) are comparable across groups or over time. Conventional methods for evaluating MI in PROMs are mostly group-based methods that require that relevant diffe...

Prescription Patterns of Cardiovascular Medications in the Adolescent and Adult Population With Fontan Circulation—A Report From the Multicenter Single Ventricle Outcomes Network

BACKGROUND: There are limited data on prescription patterns in adolescents and adults with Fontan circulation. METHODS: We conducted a retrospective analysis of patients 13 years of age and older enrolled between 2022 and 2024 in the Fontan Outcomes Network (now SV-ONE [Single Ve...

Rationale and design of the: breast cancer, fitness and exercise for heart health (BE-FITTER trial)

As breast cancer (BC) survivorship improves, cardiovascular disease (CVD), has become the leading cause of non-cancer death in older survivors. This risk is driven by cardiotoxic treatments, underlying CVD risk factors, and sedentary deconditioning. Despite the established benefi...

Associations between a mixture of trace elements and bladder cancer occurrence

Background: The association between trace elements and bladder cancer risk is not well understood. Individuals are typically exposed to a mixture of multiple elements simultaneously, such as through water pollution or diet. While previous studies have explored associations betwee...

Noncarbohydrate Inhibitors of Sialic Acid-Binding Immunomodulatory-Type Lectin-7 (Siglec-7) Discovered from Genetically Encoded Bicyclic Peptide Libraries

ABSTRACT Glycan-binding proteins (GBP) are among the most difficult to drug targets. This deficiency delays clinical progress for therapeutically important GBPs. We employed bicyclic genetically encoded libraries (BiGELs), produced by chemical modification of phage-displayed libr...

Anion–π Interaction‐Regulated Ion Generation and High Piezoionic Response in Ultrasoft Low‐Salinity Hydrogels

ABSTRACT Anion–π interactions play important roles in underwater cohesion and selective ion recognition and transport in biological systems. Inspired by these functions, we report the first hydrogel system employing anion–π interactions as a design motif for piezoionic energy con...

One of the Best Parts – Workplace Walk-Throughs: Findings from a 2025 Canadian Survey of Physicians Practicing in Occupational Medicine

Objective: Workplace walk-throughs (WWs) are a sine qua non for gaining experience on how workplace hazards affect health. This study examines physicians’ experiences participating in WWs. Methods: This cross-sectional study examined responses from a module on WWs in a 2025 onlin...

Presumptive Coverage Policies and Workers’ Compensation of Post‐Traumatic Stress Disorder and Other Mental Health Conditions: A Retrospective Time‐Series Study in Canada 2001–2019

BACKGROUND: The impact of presumptive coverage policies for work-related mental health disorders has not been extensively studied to date. Using data from the Association of Workers' Compensation Boards of Canada (AWCBC), our objectives were to describe the evolution of compensat...

An ABA /auxin regulatory module controlled by nitrogen governs symbiotic organogenesis in the bryophyte species Ricciocarpos natans

Summary During the terrestrialization of plants c. 470 Ma, overcoming nitrogen limitation was a major evolutionary challenge. While nonvascular plants may acquire nitrogen through rhizoids and surface diffusion, symbiotic interactions likely provide an important strategy to overc...

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Abstract Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor,...

Development and usability testing of digital knowledge translation tools for parents on sexual orientation and gender identity

Abstract Background Parents play a critical role in supporting children’s understanding of sexual orientation and gender identity (SOGI), yet many report lacking the confidence, language, or resources to initiate these conversations. Arts-based digital knowledge translation (KT)...

Absolute and Amplified Virus Detection by Isotope Dilution after Catalytic Hairpin Assembly

Abstract The detection of viruses is of great significance for the diagnosis of related diseases. However, current virus detection often faces two challenges: first, due to the complex matrix of physiological samples, detection methods often fail to provide accurate quantitative...

High-cell density two-stage self-cycling fermentation system for the enhanced production of ethanol from steam-exploded poplar hydrolysate

Abstract The economics of lignocellulosic ethanol production by Saccharomyces cerevisiae remain a challenge which can be partially addressed by improving the performance of pretreatment optimization and fermentation systems, an aspect that is too often overlooked. In this study,...

Impact of Moisture Content on the Withdrawal Resistance of Self-Tapping Screws in Timber

Abstract Self-tapping screws (STS) have emerged as the state-of-the-art connector for mass-timber structures, often taking advantage of their ability to resist high loads parallel to their axis in withdrawal. This withdrawal resistance is affected by the timber moisture content....

Fractionated Ablative Laser-Assisted Methyl Aminolevulinate Photodynamic Therapy with 532-nm KTP Activation for Multiple Basal Cell Carcinomas in Gorlin Syndrome: A Case Report

Basal cell carcinomas (BCCs) in Gorlin syndrome are often numerous, recurrent, and difficult to manage with repeated surgery because cumulative procedures may produce substantial morbidity, scarring, and disfigurement. Methyl aminolevulinate photodynamic therapy (MAL-PDT) is an e...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

A Portable Colorimetric Biosensor Platform for Urinary Colorectal Cancer Biomarker Testing in Low-Resource Settings

Early detection of colorectal cancer (CRC) is challenging in low-resource settings because access to colonoscopy and centralized laboratory testing is limited. Urine-based metabolite biomarkers offer a non-invasive alternative for CRC triage, but translating a laboratory assay in...

Ammonia as a hydrogen carrier: Engineering liquid-phase storage in underground salt caverns

Ammonia (NH 3 ) provides a complete energy value chain, but its large-scale use is constrained by the absence of a viable grid-scale storage method. This study shows that intermittent renewable production and the diverse purity demand of end-use technologies make long-duration, h...

Fluid Injection Triggers Large‐Scale Slow‐Slip Activation of the Rocky Mountain Fold and Thrust Belt

Abstract Using interferometric synthetic aperture radar (InSAR) we show that hydraulic fracturing treatments near the subsurface deformation limit of the Rocky Mountain Fold and Thrust Belt produced 12 intraplate, aseismic, slow‐slip events with magnitudes 4.71–5.06 at 1,640–2,41...

Decoding complex gold mineralization in the Pitangui Greenstone Belt, Brazil: overprinting systems revealed by pyrite trace elements and sulfur isotopes

Tracing the sources of metals and sulfur in orogenic gold deposits remains debated due to the diversity of these systems. This study constrains the origin and evolution of mineralizing fluids through trace element and sulfur isotope (δ34S) analyses of pyrite from the Papagaios go...