University of Alberta

Mastering a simulation-based parametric method to obtain bias-corrected point estimates and sampling variance for effect sizes

Abstract Meta-analyses require an effect-size estimate and its corresponding sampling variance from primary studies. For some effect size statistics, however, estimators of sampling variance are unavailable, requiring new derivations. Traditionally, such formulas are obtained usi...

Adaptive Output Tracking Control System Design With SPR‐Based Adaptive PFC

ABSTRACT Adaptive output feedback control based on an Almost Strictly Positive Real (ASPR) condition has been developed. In the control method based on the ASPR condition, its distinct feature is that an ASPR system can be stabilized by merely applying static output‐feedback cont...

Developmental Origins of Health and Disease: The role of Clostridioides difficile Colonization of Gut Microbiota During Infancy

The DOHaD theory was originally proposed to explain the link between fetal development and risk for non-communicable disease - NCD. With advancements in human microbiome research, this theory has been extended to consider postnatal development of the infant gut microbiome and how...

Reconsidering the Alberta study of the closure of the Red Deer supervised consumption site

Supervised consumption sites (SCS) are interventions supported by decades of evidence and yet remain subject to considerable politicization. Recently, researchers from Alberta, Canada published a study in the journal Addiction that sought to assess the impacts of the closure of a...

A Two-Step Synthesis of Covalent Genetically Encoded Libraries of Peptide-Derived Macrocycles Enables the Use of Electrophiles with Diverse Reactivity

Abstract Genetically encoded libraries of peptide-derived macrocycles containing electrophile “warheads” (cGELs) can be used to identify potent and selective covalent ligands for protein targets. Such cGELs are synthesized either by incorporation of unnatural amino acids that dis...

Z ‐Retentive Enantioselective Rh‐Catalyzed Hydroarylation of E,Z ‐Dienes

ABSTRACT Metal‐catalyzed additions to alkenes are among the most versatile methods to prepare enantioenriched small molecules. Processes that selectivity functionalize an E ‐alkene in the presence of a Z ‐alkene remain elusive, however, they would be an attractive approach to acc...

Thermodynamic Drivers of Rapid Transition From Drought to Flood in Siberia, Russia

Abstract Siberia is a warming hotspot under the impact of climate change, and faces growing threats from hydroclimatic extremes. The rapid transition from drought to extreme wet conditions (hereafter RTDFs) could exacerbate compound hazards, as intense rainfall on drought‐weakene...

Unveiling high functional group utilization in trace-level electrolyte additives for stable zinc anodes in aqueous zinc-ion batteries

Aqueous zinc-ion batteries suffer from zinc dendrite formation, parasitic reactions, and interfacial corrosion, which greatly hinder cycling stability. Herein, a tiny amount of small-molecule glycolic acid (GA, 0.1 wt%) with multiple functional groups as a trace-level additive is...

Multimode and Random-Access Optical Quantum Memory via Adiabatic Phase Imprinting

A photonic quantum memory that can store multiple qubits and later recall any randomly chosen subset is essential for large-scale quantum networking and computing. This capability, similar to random-access memory in classical computers, has been difficult to achieve due to the la...

Changes in the knowledge, attitudes, and practices of school teachers following an educational intervention in Skardu: a quasi-experimental study

To evaluate within-participant changes in knowledge, attitude, and practice (KAP) among school teachers following a structured educational intervention on children’s eye health in Skardu District, Gilgit-Baltistan (GB), Pakistan. This single-group pre–post quasi-experimental stud...

Revealing interphase-driven stiffness and stability in hybrid CNT/CF polymer composites via multiscale FEM

A finite element-based multiscale modeling framework is developed to investigate the effect of the interphase on the mechanical behavior of carbon nanotube/carbon fiber-reinforced polyimide (CNT/CF-RP) composites. The modeling approach consists of two hierarchical steps: (i) nano...

Anthocyanins/MgO–carbon dots obtained from Rosa canina fruit to enhance the performance of locust bean gum-sodium caseinate aerogels for intelligent packaging application

Abstract The aims of the current study were to develop locust bean gum-sodium caseinate (LBG-SC) aerogels containing anthocyanins/MgO–carbon dots extracted from Rosa canina fruit for monitoring beef meat freshness. The LBG-SC aerogels containing R. canina fruit extract (RCE, 5%)...

A MORC2 Variant Associated With Severe Intellectual Disability and Unusual Phenotype

The microrchidia CW-type zinc finger protein 2 (MORC2) gene encodes an epigenetic regulator, variants in which are often associated with Charcot-Tooth-Marie (CMT) disease type 2Z. In recent years, notable phenotypic variation has been identified in patients with different MORC2 v...

Clinical Improvement, No Improvement, and Worsening at 24 Hours Following Reperfusion in Patients With Stroke due to Large-Vessel Occlusion

BACKGROUND: Restoring blood flow to ischemic tissue is the cornerstone of acute stroke therapy and is usually beneficial. However, when reperfusion is achieved for severely injured tissue, it is often futile and may occasionally cause harm. We aim to determine the prevalence and...

Comparing Cardiac Genetic Testing Pathways: Impacts on Access, Informed Choice, and Decisional Satisfaction

Abstract Background Mainstreaming genetic testing has emerged as a strategy to improve access and reduce wait times for patients who may benefit from genetic testing. Ensuring patients fully grasp the implications of testing when formal genetic counselling is not provided, remain...

Gravitational torque drives multidecadal variations in length of day

Multidecadal fluctuations in Earth’s length of day are shown to be driven by gravitational torque and resisted by electromagnetic and topographic forces, improving our understanding of the material properties and dynamics of Earth’s deep interior.

Statistical Methods for Assessing Non-Replicable, Outlying, and Influential Studies

Quantitative evidence synthesis has become a central tool for integrating findings across multiple studies, multi-centre trials, and multi-source cohort data. However, the identification and interpretation of non-replicable, outlying, and influential studies remain insufficiently...

Agricultural practices as natural climate solutions in the Canadian Prairies

Management practices focused on environmental outcomes in agriculture can increase soil organic carbon (SOC) and reduce greenhouse gas (GHG) emissions, complementing farm production practices that provide food and a wide variety of other social-ecological services. However, evide...

A Comparison of Machine Learning Models for ICH Prognostication: An Analysis of ATACH-2 and Qatar Stroke Database

INTRODUCTION: Multiple prognostic scores have been developed to predict morbidity and mortality in patients with spontaneous intracerebral hemorrhage (sICH). These scoring models were traditionally based on statistical methods involving a limited set of variables. The advent of m...

The frequency of spawning and skipped migration in a central Canadian population of anadromous Arctic char inferred using acoustic telemetry

Understanding spawning frequency and migration behaviour is essential for managing iteroparous anadromous fishes such as Arctic char (Salvelinus alpinus). Using a decade of acoustic telemetry data from southern Victoria Island, Nunavut, we examined the frequency of marine migrati...