University of Alberta

Altered Complement and Tubular Mitochondrial Proteins Are Linked to Graft Loss in DSA+ Antibody–Mediated Rejection

Background: Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly associated with AMR. However, 30-60% of DSA + patients do not develop AMR, raising the possibility of local tissue adaptations to...

The Metabolic Revolution in Dermatology: Obesity, Insulin Resistance, and Ultra-Processed Diets as Drivers of Skin Inflammation

Inflammatory dermatoses are increasingly linked to systemic metabolic factors. Obesity and insulin resistance create a pro-inflammatory milieu that affects the skin. Adipose tissue functions as an endocrine organ secreting adipokines and cytokines that drive chronic inflammation...

Pollutant-induced changes in fish pigmentation and spatial patterns

Abstract Pigmentation abnormalities, ranging from hypo- to hyperpigmentation, can serve as biomarkers of developmental disruption in fish exposed to environmental contaminants. However, the mechanistic pathways underlying these alterations remain poorly understood. Studies have s...

Associations Between Client Characteristics, Service Utilization and Health-Related Quality of Life of Older Adults Accepting Home Care

Introduction: Currently, little is known about interactions between older home care (HC) clients health-related quality of life (HRQoL) and home care (HC) services accessed. Objective: This study aims to address the knowledge gap by evaluating changes in the HRQoL of older adult...

Chronic Mild Circadian Disruption Alters Anxiety-Like Behavior and Spatial Navigation in Adult Mice

Sleep and circadian disruption adversely impacts mental health and physiology. Such disruption varies in degree and emerges from numerous causes, ranging from severe disruption arising from rotating shift work or frequent jetlag to more mild circadian stress experienced by people...

Reconciling nitrogen fertilization effects on soil nitrification with acidification

Nitrogen (N) fertilization supports nearly half of the global population but disrupts the N cycle. While N addition is assumed to stimulate soil nitrification by increasing substrate supply and nitrifier activity, it may also inhibit nitrification via soil acidification. Resolvin...

Youth experiences and preferences for sexual health education and digital support: a community-based qualitative study

BACKGROUND: Many adolescents rely on digital sources for sexual and reproductive health (SRH) information; yet, online content is often inconsistent, inaccurate, or difficult to interpret. Digital knowledge translation strategies offer promising approaches to deliver accessible a...

Vocabulary and Input Quality Shape the Farsi Heritage Narrative Macrostructure in Farsi–English School-Aged Children

Aims and Objectives: Narrative skills are essential for literacy and academic success and are shaped by linguistic knowledge and environmental factors such as input quantity and quality. This study compares narrative macrostructure skills in heritage Farsi–English bilingual child...

Synthesis of β‐Thiolated Amino Acids: Investigation Toward the Total Chemical Synthesis of Lasso Peptide Microcin J25

Microcin J25 (MccJ25) is of special interest due to its "lariat" topology. The lasso architecture is thought to be responsible for its remarkable thermal stability (100°C for 30 min incubation) and potency against Gram-negative bacteria (i.e., MBC of ~4.75 µM against E. coli stra...

Reconstructing Solvation Structure via Strongly Nucleophilic Anions for High‐Rate and Low‐Temperature Graphite||LFP Pouch Cells in PC‐Based Electrolyte

ABSTRACT Regulating Li + solvation structure in Propylene carbonate (PC)‐based electrolytes modulates solid‐electrolyte interphase (SEI) formation and desolvation, enabling compatibility with graphite anodes. However, existing high‐ and localized high‐concentration strategies rem...

Patient-physician sex concordance and real-world disparities in cancer treatment practices and outcomes in medical oncology

The impact of sex inequities in healthcare may be magnified in medical oncology, where patients and physicians often navigate life-limiting illnesses and intensive treatments. We examined the associations among patient-physician sex concordance, treatment practices, and cancer ou...

Balanced Mix Design for RAP-Rich High-Modulus Asphalt Concrete: Comparative Analysis of Rutting, Intermediate- and Low-Temperature Cracking

The balanced mix design (BMD) framework allows engineers to incorporate high reclaimed asphalt pavement (RAP) contents by using performance tests that capture multiple distress modes. This study developed a high-performance asphalt concrete (HPAC) inspired by the French High Modu...

IRI Estimation across Varying Point Densities in LiDAR-Derived Point Clouds: Effects of Profile Extraction and Transformer-Based Classification

Abstract The international roughness index (IRI) is a widely adopted metric for quantifying road surface irregularities and assessing pavement ride quality. Traditional IRI estimation methods have relied on vehicle-mounted inertial profilers that collect data along wheel paths. W...

Common pathways and outliers in glucose catabolism across Trypanosomatidae

Glucose catabolism in trypanosomatids differs significantly from that in most other eukaryotes. Here, the first few enzymes of the pathway are all located inside glycosomes, that is, the peroxisome‐like microbodies uniquely present in the Kinetoplastida and Diplonemida of the Eug...

Linking Magmatism and Gold Mineralization at the Fenelon Gold Deposit, Northern Abitibi, Canada: Insights from Pyrite Chemistry, U-Pb and Re-Os Geochronology

Abstract The Fenelon gold deposit, located in the underexplored northern region of the Abitibi greenstone belt, hosts an estimated 4.09 Moz at 3.20 g/t Au and is spatially associated with the 2697 ± 0.96 Ma Jeremie diorite (isotope dilution-thermal ionization mass spectrometry [I...

The Hoof as the Sentinel of Systemic Failure: The Lameness Triad and the Susceptibility–Resilience Gate in Dairy Cows

Lameness is a major welfare and economic disorder in dairy production and a clinical sign with multiple causes. This review focuses on claw horn disruption lesions (CHDL), a major cause of periparturient lameness. Although hoof-centered prevention and treatment remain essential,...

Sociodemographic factors associated with anticipatory perceived labor vulnerability related to the Russia–Ukraine war among workers in Latin America

Abstract Introduction The COVID-19 pandemic disrupted labor markets in Latin America, a region characterized by high informality, socioeconomic inequality, and uneven social protection. Shortly afterward, the Russia–Ukraine war generated global uncertainty regarding inflation, co...

Performance of the 2025 ASAS-Spartan Revised Classification Criteria for Axial Spondyloarthritis in a Canadian Multicenter Inception Cohort with Psoriasis, Uveitis, or Colitis Presenting with Undiagnosed Back Pain

Objectives To test the performance of the 2025 ASAS-SPARTAN Revised Classification Criteria for Axial Spondyloarthritis (axSpA)[1] in a multicenter inception cohort of patients with undiagnosed chronic back pain attending dermatology, ophthalmology, and gastroenterology clinics w...

End of life in the ICU: A scoping review of factors associated with moral distress in critical care nurses

BACKGROUND: Moral distress is common among critical care nurses providing end-of-life (EOL) care, yet contributing factors are not fully synthesized. PURPOSE: To summarize the literature on factors influencing moral distress in adult ICU nurses delivering EOL care. METHODS: A sco...

Patient Perspectives on the Environmental Impact of their Advanced Therapy Injection Device

Objectives Data demonstrates there is a significant environmental impact using medications requiring injection, including the injecting device and needle. Rheumatology patient perspectives on this impact have not been previously explored. As part of a larger study, we aim to repo...