University of Alberta

Sex Disparity in Enrolment to Clinical Trials for Onchocerciasis and Trachoma

To determine whether female enrolment in randomized interventional clinical trials for onchocerciasis and trachoma reflects the real-world sex distribution of disease burden, and to evaluate sex-based differences across trial characteristics. We performed a cross-sectional analys...

Leaf–Litter–Soil C:N:P Stoichiometry Varies with Stand Age in Three Subtropical Plantation Types

Stoichiometry provides an integrative framework for evaluating nutrient dynamics in plantation ecosystems. However, whether stand-age-related changes in leaf–litter–soil carbon (C), nitrogen (N), and phosphorus (P) stoichiometry are consistent among plantation types remains uncle...

Gender History: A Necessary Key to Understanding Central Europe

Abstract Seven specialists in Central and East Central European history have come together to discuss the state of the field of gender studies in their subfields. Much emphasis is placed on thinking about how the current political situation in the 2020s is affecting what historia...

Interaction of internal waves impinging upon stratified turbulence

In the ocean, internal wave beams are generated by the barotropic tide passing over steep topography. Observations suggest that these wave beams are dissipated as they propagate into the upper ocean. This differs from idealised numerical simulations of wave propagation, in which...

Seismic Stability of Steel Wide Flange Columns in Concentrically Braced Frames: Response and Design Recommendations

Abstract This paper evaluates the seismic stability response of wide flange steel concentrically braced frame (CBF) columns and proposes drift-based stability design recommendations for such columns under seismic loading. Four full-scale tests were conducted on seismically compac...

Automatic Inspection of Flexible Parts Using Virtual Fixturing

A flexible part has no unique shape until it is constrained, which makes dimensional inspection difficult. Standard practice clamps it in a dedicated jig and probes it with a coordinate measuring machine or a range sensor. We replace the jig with virtual fixturing. From partial r...

Analysis of mixed radiation fields at the MoEDAL experiment based on real-time data from a Timepix detector network

Abstract The primary objective of this work is the determination of fluences and characteristics of fast neutrons, other hadrons, and highly ionizing particles (HIPs) in the environment of the MoEDAL experiment at the Large Hadron Collider. These particles may constitute an exper...

Ser715 Phosphorylation Induces β-Hairpin Unfolding and Destabilization of FOXM1 Autoinhibition.

FOXM1 is a cell proliferation-driving transcription factor activated by phosphorylation-induced conformational changes. In its inactive state, an intramolecular β-hairpin within the transactivation domain (TAD) binds the N-terminal repressor domain (NRD), forming a composite β-sh...

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

OBJECTIVE: We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. METHODS: We enrolled patients within 3 months of JIA diagnosis in th...

Stochastic Reproduction Number and Ergodicity of a Saturated-Incidence SIHR Rumor Model with Optimal Control

This paper develops a stochastic susceptible–infected–hesitating–removed (SIHR) rumor model with Hill-type saturated incidence and compartment-specific Brownian perturbations. The model focuses on when environmental noise changes a rumor’s deterministic fate and how long-run beha...

Soft sensor design using domain-adversarial Gaussian processes—A transfer learning framework

The main objective of this paper is to develop a soft sensor for prediction of quality variables when training and test data come from similar but different distributions. The challenge is to develop a soft sensor when only limited labeled data are available, which requires trans...

Centering equity, diversity and inclusion in environmental evidence synthesis: from awareness to action

Abstract Knowledge generated through evidence synthesis is an approach that decision-makers can take to inform policy and management decisions. Evidence syntheses, such as systematic reviews, provide quantitative and qualitative summaries of this evidence, using structured method...

Sex & Gender Science: integrating the social with the biological

Abstract For decades, researchers have largely studied aspects of sex and gender separately; the former as a basic science and the latter as a social construct with real world consequences, including health inequities. In recent years, as our collective understanding of how the b...

Prophylactic administration of caffeine reduces bronchopulmonary dysplasia in very preterm infants: a single center, randomized controlled trial

Caffeine has been widely used to prevent apnea in very preterm infants (VPIs), but it is not clear whether prophylactic administration of caffeine can prevent bronchopulmonary dysplasia (BPD) in VPIs. This single-center, randomized clinical trial recruited very preterm neonates (...

Elucidating the Requirements for microRNA-Mediated Upregulation Enables Reengineering of Upregulatory Sites

Abstract The post-transcriptional regulation of protein expression by miRNA has given rise to new technologies for therapeutic interventions and synthetic biology. To date, these technologies assume that miRNAs are repressors of protein expression; however, emerging evidence has...

Postpartum cardiac structure and organ homeostasis following regulatory T cell depletion in early pregnancy

Maternal insufficiency in regulatory T (Treg) cells in pregnancy impairs maternal-fetal immune tolerance and uteroplacental vascular adaptation. Whether Treg cell insufficiency in pregnancy has maternal postpartum consequences is unknown. Using Foxp3 DTR mice, wherein diphtheria...

Diagnostic yield of repeat CT pulmonary angiography after a negative examination in the emergency department

PURPOSE: Although repeat CT pulmonary angiography (CTPA) after a negative index examination in the emergency department (ED) is common, its diagnostic utility remains uncertain. This study aimed to determine the incidence and diagnostic yield of repeat CTPA after a negative index...

Leveraging prompt-driven generative AI for systematic reviews in digital psychiatry: A stage-matched comparative proof-of-concept for healthcare researchers and clinicians

The scale and pace of evidence generation in digital psychiatry increasingly exceed the capacity of traditional systematic literature review (SLR) methods. Large language models (LLMs) are gaining traction in evidence synthesis, yet limited guidance exists for integrating generat...

Blue-sky thinking about pronunciation research and teaching

Abstract In the fall of 2024, Ron Thomson and Tracey Derwing invited 15 pronunciation scholars representing several subspecialties to participate in a full-day symposium to discuss directions for pronunciation research. To prepare for the symposium, held in conjunction with the P...

Learning about Democracy through Disputes over the Meaning of Indigenous Consent and Consultation

Abstract Disputes over the meaning of Indigenous consultation and free, prior, and informed consent (FPIC) are disputes about democracy. When states reduce these processes to procedural compliance, they collapse plural democratic traditions into a single, state-centric framework....