University of Alabama at Birmingham

Circadian Systems and Neural Control of Blood Pressure

Abstract Purpose of Review Blood pressure (BP) follows a robust circadian rhythm and disruption of this rhythm is associated with hypertension and increased cardiovascular disease risk. This review discusses the current understanding of how circadian mechanisms regulate the neura...

Widespread Loss of Heterozygosity and Endoreduplication in Odontogenic Myxoma

Odontogenic myxoma (OM) is an uncommon, locally aggressive odontogenic neoplasm with characteristic histologic and clinico-radiographic features but with potential for histologic overlap with other odontogenic and non-odontogenic entities and a non-specific immunoprofile. Widespr...

Early Palliative Care Is Feasible and Acceptable in Pediatric Neuro‐Oncology

BACKGROUND: Children with central nervous system (CNS) tumors face high morbidity and mortality, yet often do not receive palliative care (PC). There is evidence of the benefit of PC in pediatric oncology, though the ideal timing remains unknown. We aimed to evaluate the feasibil...

Congenital Syphilis at a Tertiary Care Center in Alabama

BACKGROUND: Congenital syphilis (CS) remains a preventable yet increasing public health concern in the United States. Previous studies have indicated that CS management itself is frequently not consistent with Centers for Disease Control and Prevention (CDC) recommendations. In A...

Laryngeal Carcinoma Treatment Outcomes in Female Patients

ABSTRACT Objective This study aims to describe characteristics of female patients with laryngeal cancer and to compare surgical and non‐surgical treatment. Methods A retrospective cohort study was performed as a multicenter study with data collected from all female patients diagn...

Chemical Editing Reveals Atomic-Level Control of Supramolecular Structure in Self-Assembling Peptides

Abstract Can replacement of single atoms within amino acid sequences redirect peptide self-assembly into different supramolecular structures? To address this question, we investigated a compositionally similar class of bola-amphiphilic peptides that were designed to self-assemble...

Translocator protein targeted molecular imaging in idiopathic pulmonary fibrosis

Targeted molecular imaging utilizing positron emission tomography (PET) technology may provide a non-invasive biomarker in idiopathic pulmonary fibrosis (IPF). Translocator protein (TSPO, 18 kDa), a mitochondrial outer membrane protein, is upregulated in persistent injury and inf...

Recruitment and Engagement in Care to Impact Practice Enhancement for Patients with Sickle Cell Disease: Study Protocol

Abstract Objectives To adapt an evidence-based linkage coordinator model used in HIV care to identify, engage, and link adults with sickle cell disease (SCD) who are unaffiliated from specialty care to SCD specialists, and to assess implementation readiness, processes, outcomes,...

Burden and Risk Factors for Severe Respiratory Syncytial Virus Infection Among Pediatric Hematopoietic Cell Transplant Recipients

BACKGROUND: Respiratory syncytial virus (RSV) causes substantial morbidity in pediatric hematopoietic cell transplant (HCT) recipients; however, risk factors for severe disease remain incompletely characterized. METHODS: We conducted a multicenter retrospective cohort study acros...

In Situ Multiscale Imaging Reveals Cellular Selection and Remodeling of Peptide Assemblies from Membrane Perturbation to Actin Dysregulation

Abstract Enzyme-responsive peptide nanomaterials can induce non-apoptotic cancer cell death, yet the supramolecular states that mediate activity in cellular environments are usually inferred rather than directly resolved. Here, we integrate multiscale in situ imaging with biochem...

Maternal neighborhood deprivation and its association with early childhood neurodevelopmental impairment in extremely preterm infants

Abstract Objective Evaluate whether maternal Area Deprivation Index (ADI) is associated with neurodevelopmental impairment (NDI) at age 2 in extremely preterm infants. Study design Retrospective cohort study of infants <29 weeks’ gestation at four NICUs spanning multiple US regio...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Updated COVID ‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions

OBJECTIVE: We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECMO), and death in people with autoimmune rheumatic conditions. METHODS: We conduct...

Optimizing Treatment of Infective Endocarditis in Patients Who Inject Drugs

The treatment of infective endocarditis (IE) in patients who inject drugs (PWID) is complex and challenging. These patients face stigma in the healthcare system, as well as higher mortality, longer length of hospital stay, higher rates of recurrent infections, and lower likelihoo...

European Association of Palliative Care White Paper on research priorities for family caregiving in palliative care: A systematic review of reviews

BACKGROUND: Family carers are central to providing high quality palliative care. However, gaps remain in our understanding of how best to support carers. In 2010, the European Association for Palliative Care published a White Paper on 'Improving Support for Family Caregivers'. Th...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Comparison of Empiric Antibiotics With and Without MRSA Coverage in Staphylococcal Scalded Skin Syndrome

PURPOSE: Treatment of staphylococcal scalded skin syndrome (SSSS) typically covers methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA). However, limited data exist to show an optimal antibiotic regimen. We hypothesized that empiric antibi...

Cholesterol Management Gaps Among Patients With Established Coronary Artery Disease Hospitalized for Acute Coronary Events

BACKGROUND: Suboptimal cholesterol management in patients with coronary artery disease (CAD) may contribute to future cardiovascular events and increased health care utilization and costs. OBJECTIVES: The objectives of the study was to assess lipid-lowering medication use and low...

Programmatic access to ICTV virus taxonomy through a public ontology API

Abstract Background The International Committee on Taxonomy of Viruses (ICTV) is responsible for developing and maintaining a universal virus taxonomy. As the reference framework for organising the viral world, it is essential for virology and related fields. Despite its widespre...

Menopausal Hormone Therapy and Cardiovascular Risk: Current Evidence and Treatment Recommendations

In 2025, the US Food and Drug Administration (FDA) removed its prior class-wide boxed warnings for menopausal hormone therapy (MHT), paving the way for increased clinical use. Menopause accelerates cardiovascular risk independently of chronological aging, manifesting as a 7.5% in...