Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens
Open access1 citations
Abstract
Intestinal epithelial cells can present antigen to CD4 T cells. Here the authors show that epithelial cells must present translocated bacterial antigen for local CD4 resident memory T cells to be established.
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Authors: C. Garrett Wilson, M. Pragun Acharya, Laura Karsch, Lennard Wayne Duck, Nana Twumasi-Ankrah, Yuanyou Wang, Hongxing Shen, Blake F. Frey, Annalisse R. McKee, Vishal H. Oza, Stacey N. Harbour, Yoshiko Nagaoka-Kamata, Jeffrey R. Singer, Robin D. Hatton, Jeffrey R. Moffitt, Matthias Gunzer, Carlene L. Zindl, Casey Todd Weaver
Institutions: University of Alabama at Birmingham, University of Duisburg-Essen, Boston Children's Hospital, Vanderbilt University Medical Center, Essen University Hospital