Comparison of prenatal self-report of tobacco use to direct measurement of umbilical cord cotinine
Abstract
Abstract Objective This study compared maternal self-reports of prenatal tobacco product use with biochemically confirmed cotinine in umbilical cord tissue in newborns exposed to opioids in utero and unexposed controls. Study design Secondary data analysis on 179 pregnant women and newborns. Chi-square and t -tests were used to compare sociodemographic factors of those who did and did not self-report tobacco use. Results Mean (SD) maternal age was 29.5 years (5.0); 85.2% had public insurance, and 92 (51.4%) took opioids prenatally. Ninety-five (53.1%) mothers self-reported prenatal tobacco product and/or e-cigarette use, with cord cotinine detected in 98.9%. Of the 84 reporting no use, cotinine detection was 34.5%, resulting in moderate agreement (Gwet’s AC1 = 0.68 (0.571, 0.788), p < 0.001). Of those reporting no use, 27 (32.9%) had cotinine detected ( p = 0.038). Conclusions Biochemically verified cotinine detection was much higher than maternal self-reports of prenatal tobacco use. Inquiring about household and community smoke exposure may help inform optimal care.
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Authors: E. Melinda Mahabee‐Gittens, Nicole Mack, Carla Bann, Jamie E. Newman, Hongying Daisy Dai, Junfang Zhao, K D Setchell, Lara Stone, Namasivayam Ambalavanan, Myriam Peralta-Carcelén, Sara B. DeMauro, Scott A. Lorch, Deanne E. Wilson-Costello, Brenda Bradley Poindexter, Catherine Limperopoulos, Jonathan M. Davis, Stephanie L. Merhar
Institutions: University of Alabama at Birmingham, Cincinnati Children's Hospital Medical Center, Children's Hospital of Philadelphia, University of Cincinnati Medical Center, Perinatal Institute, Emory University, Case Western Reserve University, Children's National, RTI International, University of Cincinnati, Tufts Medical Center, University of Nebraska System