University of Alabama at Birmingham

Porphyromonas gingivalis Promotes Lipid Droplet–Mediated Microglial Dysfunction

Growing evidence supports a strong association between periodontitis and Alzheimer’s disease (AD), yet the mechanisms linking these conditions remain poorly defined. In neurodegenerative disorders, including AD, microglia are often characterized by increased accumulation of lipid...

Research Priorities for Neuroscience Nursing: 2026 Update

BACKGROUND: The American Association of Neuroscience Nurses established a 6-member Research Agenda Task Force in 2025 to update and define neuroscience nursing research priorities to lead the field for the next 5 years. The last research priority setting was completed in 2021. ME...

Financial Toxicity and Quality of Life After Bone Marrow Transplant: A Longitudinal, Prospective Study

PURPOSE Financial toxicity is common after bone marrow transplant (BMT) and is associated with worse quality of life, but longitudinal patterns remain poorly understood. METHODS We conducted a prospective cohort study of insured adults undergoing allogeneic BMT (2018-2023). Finan...

Comparative effectiveness of GLP-1 receptor agonists, SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas on weight change among people with HIV: a real-world longitudinal cohort study

Obesity is common among people with HIV (PWH), yet evidence on weight loss with newer antidiabetic medications in this population is limited. We compared bodyweight change associated with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium–glucose cotransporter-2 (SGLT2)...

Development of a Self-administered Sexual Behavior Assessment Tool to Facilitate Self-reflection by Young Women in South Africa About HIV/STI Risk

Abstract Self-assessment of sexual behavior may empower adolescent girls and young women (AGYW) to reflect on HIV/STI risk and adopt prevention strategies. We developed a web-based sexual behavior self-assessment tool providing real-time feedback based on a numeric score and exam...

Heat-Inactivated Lactiplantibacillus plantarum (RSB11) as a Multifunctional Postbiotic: Anti-Inflammatory Effects Compared with Live RSB11 Across Multiple Human Cell Models

The clinical potential of probiotics is increasingly recognized; however, dependence on microbial viability, formulation and storage constraints, and safety considerations in vulnerable populations can limit their broader application. Postbiotics offer an alternative by providing...

Children with sickle cell disease hospitalized for acute pancreatitis have an increased disease burden

Abstract Objectives Children with sickle cell disease (SCD) are at increased risk of developing gallstones, a common etiology of acute pancreatitis (AP). We aimed to determine if children with SCD admitted to children's hospitals for AP will have an increased burden of AP compare...

Effect of Semaglutide on Thigh Skeletal Muscle Volume, Fat Infiltration and Physical Function in People With Obesity: Secondary Analysis of STEP UP

ABSTRACT Aims To assess the effect of semaglutide on body composition and physical function. Materials and Methods The phase 3b STEP UP trial randomised adults with body mass index ≥ 30 kg/m 2 to once‐weekly subcutaneous semaglutide 7.2 mg, semaglutide 2.4 mg or placebo for 72 we...

Multiscale model calibrated with a Bayesian algorithm predicts long-term outcomes of treatments for mitral valve regurgitation in animal models

In primary mitral valve regurgitation (MR), a failing valve induces volume overload (VO) of the left ventricle (LV), triggering neurohormonal responses and myocardial remodeling. Surgical valve repair is the most effective therapy for MR, improving symptoms and in some patients r...

Tangier Disease

Abstract Purpose of Review We describe two patients with Tangier disease (TD) and provide a narrative review of its clinical features, genetics, diagnosis, and management. A literature search of PubMed and Google Scholar was performed to identify English-language publications on...

Ameloblastoma With Glandular Differentiation

Ameloblastoma with mucinous and/or glandular differentiation is exceedingly rare and not currently recognized by the World Health Organization (WHO) as a morphologic subtype. We report a KRASG12R -mutated mandibular ameloblastoma with mucinous glandular differentiation in a 72-ye...

On-Surface Molecular Design and Synthesis of Discrete Metal–Fullerene Complexes on Graphite

Abstract On-surface synthesis enables the fabrication of molecular complexes, which cannot be obtained through traditional solution chemistry. Generally, metal substrates have been used due to their catalytic properties. Here, a tripod-like magnetic molecular complex, (C60)3–Co,...

Closing the Gap: Improving Access to Parathyroidectomy for Secondary and Tertiary Hyperparathyroidism

Background Patients with secondary and tertiary hyperparathyroidism (SHPT/THPT) may encounter unique demographic and geographic barriers to timely parathyroidectomy that differ from those experienced by patients with primary hyperparathyroidism (PHPT). Methods A retrospective coh...

Development and pilot implementation of an educational program for concurrent use of non-steroidal anti-inflammatory drugs and glucocorticoids in older veterans with rheumatic diseases

Abstract Background Polypharmacy is common among aging Veterans with rheumatic and musculoskeletal diseases (RMDs). Veterans who concurrently use glucocorticoids (GCs) and non-steroidal anti-inflammatory drugs (NSAIDs) have higher risk of adverse events. We created the ScaLable M...

Renal Imaging Characteristics Predicting Percutaneous Access for Staghorn Stone Management

Abstract Purpose of Review Preoperative planning in staghorn stones treated with percutaneous nephrolithotomy (PCNL) can improve efficiency and minimize complications. We summarized the current evidence on imaging features to guide the selection of optimal access for managing sta...

A Causal Model for Prehospital Blood Transfusion and Mortality in Traumatic Hemorrhagic Shock

OBJECTIVES Utilization of prehospital blood transfusion (PBT) as a treatment for traumatic hemorrhagic shock (THS) has been expanding nationally, yet evidence supporting the practice in some operational environments remains limited. Development of strong scientific evidence to su...

School Readiness and Home Visiting: A Scoping Review of Definitions, Outcomes, and Contextual Moderators

Abstract This scoping review examined empirical research on the relationship between participation in home visiting programs and children’s school readiness at the time of school entry. Specifically, we explored how school readiness is defined across studies, which domains are as...

Developmental Sialylation in Neuroblastoma and Neural-Crest-Derived Tumors

Pediatric malignancies are often closely linked to developmental cell states, differentiation trajectories, and restricted developmental windows. This relationship is especially evident in neural-crest-derived tumors, where malignant cells may retain, remodel, or reacquire glycos...

Apolipoprotein E Mimetic Peptide-Mediated Modulation of Lipid Homeostasis

Lipid homeostasis is essential for maintaining cellular function and metabolic balance in all organisms, and its dysregulation can contribute to hypercholesterolemia, atherosclerosis, and cardiovascular disease. Adverse health outcomes are associated with elevated levels of low-d...

Outcomes of AO/OTA 43C Pilon Fractures Treated With Open Reduction Internal Fixation or Tibiotalocalcaneal Nailing

Background: AO/OTA 43C pilon fractures are severe intra-articular distal tibia injuries associated with high complication rates. Although open reduction internal fixation (ORIF) remains the standard treatment, tibiotalocalcaneal (TTC) nailing has been used in select patients; thi...