University College London

Political Economy of Manchesterism

ABSTRACT This paper presents an intellectual history of Manchesterism. It explains the ruling ideas that have shaped the recent development of Greater Manchester and critically assesses their application. It pays particular attention to the evolution of inequality in Greater Manc...

Distribution of device-measured 24-hour movement behaviours across the cognitive spectrum in older adults: the HUNT study

Abstract Background Key daily physical activities (e.g., standing and walking), postures (sitting and lying), and sleep constitute the 24-h day and have distinct health effects and functional implications. Traditionally studied separately, the distribution of these movement behav...

Modeling driver cognitive states for shared-control vehicles in intelligent transportation systems

This study aims to model driver cognitive states for shared-control vehicles operating within intelligent transportation systems. We introduce driving activity level as an interpretable state variable that combines attention allocation, steering behavior, and perceived situationa...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

Element-Specific DonorNumbers for Anions

Abstract Anion interactions with cations/molecules are crucial across chemistry and biology: in battery electrolytes, synthesis, atmospheric processes, and protein denaturation. Selecting the optimum anion represents an immense challenge, as anion interactions are diverse and com...

Pedagogy in the speech-gesture couplings of caregivers: Evidence from a corpus-based analysis

In face-to-face communication, representational gestures-imagistically evoking properties of referents-support both language comprehension and development. In adult-adult interaction, representational gestures are systematically produced before the words they are semantically rel...

Does the AMPD1 C34T Polymorphism Influence Physical Performance in Elite Athletes?

Background/Objectives: Adenosine monophosphate deaminase deficiency has been implicated in impaired exercise capacity. We examined whether the AMPD1 C34T (rs17602729) genotype was associated with athlete status and performance in distance runners (DR) and rugby union (RU) athlete...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Tear Cytokine Signature in Vernal Keratoconjunctivitis: A Chemokine-Remodeling Axis Associated with Disease Severity

Vernal keratoconjunctivitis (VKC) is a chronic pediatric ocular allergy that can progress from seasonal to persistent inflammation with vision-threatening complications. Although Th2-associated mechanisms have been implicated, the immune correlates of disease severity are not wel...

Deciphering the Roleof Hydrophobic Amino Acid l -Methionine in Tuning CO2 Hydrate Kinetics:Insights from Molecular Dynamics Simulations

Abstract CO2 clathrate hydrate has emerged as a promising medium for carbon sequestration owing to its exceptionally high CO2 storage capacity and intrinsic stability in subsea environments. Sluggish growth kinetics hinder its field application and large-scale deployment. The hyd...

Automatic value learning results in counterproductive human behavior

Abstract Humans are adept at accurately estimating the value of available choices from accumulated experience. However, cognitive processing also incorporates irrelevant information during deliberation, undermining decision accuracy. Here, we show that credit assignment operates...

Exploring new measures of accuracy in second language task-based spoken performance

Abstract This article focuses upon the measurement of accuracy in second-language task-based spoken performance, with measures related to unit of analysis, error gravity, and accuracy linked to clause length. Building on established indices, three new measures of accuracy, all li...

The Co-Occurrence of Postural Orthostatic Tachycardia and Functional Neurological Disorder: A Meta-Analysis and Narrative Synthesis

Background: Functional Neurological Disorder (FND) and Postural Orthostatic Tachycardia Syndrome (POTS) are both complex, often debilitating conditions that frequently affect young women and involve high symptom burdens and psychiatric comorbidity. Although clinical overlap betwe...

Tell Your Story: Strengthening Scientific Engagement and Welfare Leadership among Animal Technologists

<ns5:p>Background Animal Technologists (ATs) are vital in the scientific community, offering crucial expertise in animal care, welfare, and experimental procedures. As projects become more complex, there is an increasing opportunity for ATs to engage actively in scientific projec...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

“The university is the foundation of ethics”: Views of postgraduate students on an MA Education course towards research ethics

Scholarship has emphasised the importance of teaching research ethics within the university context, yet also highlights the challenges involved. Two key barriers may be identified: the conceptualisation of research ethics, and the language found on applications for ethical appro...

Awake craniotomy for drug-resistant non-oncological epilepsy: a systematic review of feasibility, reported safety, and seizure outcomes

Abstract Introduction Complete resection of the epileptogenic zone offers the best chance of seizure control in patients with drug-resistant epilepsy. However, surgical management remains challenging when the epileptogenic zone is located within or adjacent to eloquent brain regi...

Early Longitudinal Brain Network Changes in Huntington's Disease Before Clinical Motor Onset

Abstract Background Longitudinal studies of seed‐based functional connectivity (SBFC) in young adult Huntington's disease gene‐expanded (HDGE) individuals are rare, and none, to our knowledge, have examined adult cohorts decades from predicted clinical motor diagnosis. Objectives...

Where Does the City Grow? Residual Floor Area and the Determinants of Residential (Re)development in São Paulo

Using a novel block-level dataset covering all residential (re)developments in São Paulo, this paper examines why some blocks are (re)developed while others are not. Consistent with development-viability theory, the results show that blocks with greater residual development poten...