The University of Sydney

Predictive validity of the Addenbrooke’s cognitive Examination III for on-road driving outcomes in a clinical fitness-to-drive population: a prospective cohort study

Background Evidence-based fitness-to-drive assessment must balance public safety and fairness. Cognitive screens are commonly used, but must be accurate in high-stakes contexts. The predictive utility of the Addenbrooke’s Cognitive Examination III (ACE-III) for driving outcomes r...

Transdiagnostic symptoms of psychopathology interact with changes in environmental uncertainty

Abstract Uncertainty is a potential driver of poor mental health outcomes, and uncertainty is mounting across domains of daily life. It remains unclear how symptoms of anxiety and depression emerge in response to uncertainty in real-life contexts. The current study investigated h...

Newcastle disease virus is a safe and immunogenic respiratory-delivered vaccine against SARS-CoV-2 in a ferret model

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused close to 800 million infections and over 7 million deaths worldwide. In addition to its impact on human health, the virus has shown cross-species transmission, including spillover into mustelids such as m...

Factors associated with bowel cancer screening participation among First Nations Peoples receiving home health care services in New South Wales, Australia

First Nations Australians consistently exhibit lower bowel screening participation rates than non-First Nations Australians. However, limited studies have been conducted to understand the factors associated with bowel cancer screening participation among First Nations Australians...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

Why are there so many different guidelines? A qualitative study of the low back pain policy landscape in Australia

Low back pain is a major cause of disease burden around the world. The sheer number and variety of back pain guidelines developed in Australia suggests that there are drivers within the low back pain care landscape to promote development of guidelines which are produced by a wide...

Tinkering at the margins? Korea’s reform strategies to close the gap between labour market insiders and outsiders

Over a relatively short period, Korea has developed a comprehensive welfare state centred on eight social insurance schemes. However, its heavy reliance on contributory social insurance has become increasingly inadequate for protecting atypical and non-regular workers, an expandi...

Gender Inequality and Social Capital in Academic Finance Networks

Abstract Finance academia remains heavily male dominated, yet the mechanisms driving women’s underrepresentation are not fully understood. This study examines how co-authorship networks shape gendered access to and mobilisation of social capital by integrating Social Capital Theo...

Approved Monoclonal Antibody Therapies for Hidradenitis Suppurativa

Importance Biologic therapies are increasingly used for moderate to severe hidradenitis suppurativa (HS), yet their high cost presents challenges for health systems and payers. Comparative economic evaluations of these therapies are limited. Objective To evaluate the efficiency f...

Implementing evidence in residential aged care facilities: a longitudinal multi-method evaluation of knowledge broker evolution

Background Knowledge brokers act as intermediaries to bridge evidence-to-practice gaps. Limited evidence describes how the knowledge broker role in health settings evolves over time. This study aimed to (a) examine the evolution of knowledge broker activities over a 12-month impl...

Reimagining land system science in seascapes

Abstract Context Terrestrial concepts often guide the science and management of marine systems, as exhibited by the influence of landscape ecology on seascape ecology. However, the theoretical assumptions that inform these concepts have not been sufficiently interrogated within t...

Global trade-offs between consumption, carbon prices and equity

As the remaining carbon budget continues to dwindle, economic growth strains efforts to limit global warming to 1.5 °C. Reducing unnecessary production and consumption in high-income regions and among the wealthy, and organising production more around human needs and human well-b...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

How Feasible is the Use of Saliva for Antiviral Therapeutic Drug Monitoring? A Systematic Review and Analysis

Immunosuppressed patients are susceptible to serious viral infections, often necessitating antiviral prophylaxis and/or treatment. Therapeutic drug monitoring (TDM) has been proposed to optimise drug exposure and clinical outcomes and is typically performed on full blood/plasma s...

Progress in reaching zero-dose children: analysis of population-modifiable risk factors and inequity trends in low- and lower-middle-income countries

Zero-dose (ZD) children remain concentrated in low- and lower-middle-income countries (LLMICs) and are a major focus of the Immunization Agenda 2030 (IA2030), which aims to halve their number by 2030. Despite this commitment, progress has stalled in many high-burden settings. Thi...

Development and preliminary evaluation of a digital platform for surgical anatomy education

The transition from foundational anatomy education to applied surgical anatomy remains a persistent challenge in medical and surgical training. This study describes the development and preliminary evaluation of Anatomy Unlocked , a mobile-first, clinically oriented digital anatom...

Impact of Continuous Positive Airway Pressure Treatment on Retinal Vasculature in Obstructive Sleep Apnea: A 7-Year Follow-Up

Purpose: In previous studies, obstructive sleep apnea (OSA) severity at diagnosis was independently associated with retinal arteriolar narrowing and reduced retinal pulse amplitude. Participants with severe untreated OSA showed progressive retinal arterial narrowing 2 years post...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Rehearsing Responsiveness: Coaching Preservice Teachers to Work Within and Beyond Standardized Lesson Plans

ABSTRACT Centrally developed English lesson plans provide structure and ensure curriculum coverage, yet they can constrain preservice teachers' creativity, responsiveness, and capacity to engage students meaningfully. Although this tension is well documented, there is limited pra...

Photometry for highly saturated TESS stars

Saturation in TESS complicates simple aperture photometry, as flux can be lost to bleeding outside the target pixels. Halo photometry can nevertheless reconstruct good light curves of these stars, as a weighted linear combination of pixel time series from the unsaturatedwings of...