The University of Sydney

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Peptide binders provide a versatile modality for modulating protein targets that are poorly addressed by small molecules, but their discovery is constrained by sample-intensive screening or reliance on structural templates. Sequence-first generation offers a scalable alternative...

Physical activity from bus travel: objective estimates linking accelerometer and travel card data

Background Low physical activity contributes to chronic disease and premature death. Public transport can integrate activity into daily routines, but robust methods are needed to estimate physical activity during public transport trips. This study quantified duration, intensity,...

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo‐Controlled Trial

BACKGROUND: Lower testosterone concentrations in older men are associated with poorer health outcomes. OBJECTIVE: We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing,...

Hyperbolic confinement: self-assembly of asymmetric diblock co-polymers on triply periodic minimal surfaces

Abstract We investigate the self-assembly of compositionally asymmetric AB diblock co-polymers confined to thin hyperbolic films on the three cubic minimal surfaces: the primitive, the diamond and the gyroid. To analyse and quantify the assemblies, we use a computational pipeline...

Steric stabilizers inhibit or enhance enzymatic digestion depending on the internal nanostructure of lipid nanoparticles

Abstract Lipidic nanoparticles (LNPs), including liposomes and cubosomes, are widely employed drug delivery systems owing to their biocompatibility and capacity for stimuli-responsive ‘smart’ drug release. Steric stabilizers, including DSPE-PEG-2000 and Pluronic F127, are commonl...

Effects of a neuromuscular warm-up on Y-balance, countermovement jump performance, and stroke velocity in adolescent table tennis players

Background/Objective Adolescent table tennis players are exposed to substantial physical and psychological demands during a period of ongoing growth and development, placing high demands on movement control, explosive performance, and sport-specific stroke execution. This study i...

Upward single-nozzle sprays: Droplet count, size, and velocity under flash pressures with directional conditional filtering

This study investigates the influence of pressure variation on droplet characteristics (count, size) and dynamics (velocity) in upward atomised full-cone sprays. The challenges of understanding the fundamental droplet behaviour in spray-flash desalination systems further imposes...

Seeing Inequalities: Self-Reported Visual Difficulty and Eye Care Utilization Among Women in Malawi, a Secondary Analysis of the 2024 Demographic and Health Survey Data

Background: This study aimed to identify the factors associated with self-reported visual difficulty and uptake of spectacle/contact lens correction among women of reproductive age in Malawi. Methods: We conducted a cross-sectional secondary analysis of the 2024 Malawi Demographi...

Prenatal Genomics for Sonographers: Enhancing Confidence, Communication, and Clinical Care

ABSTRACT Genomic medicine is advancing rapidly, bringing significant changes to prenatal care and expanding the role of health professionals. As clinicians responsible for performing prenatal ultrasounds which may detect fetal anomalies and ultimately lead to genetic diagnoses, s...

The impact of fuel prices and supply availability on user behavioural change in Australian household travel amidst global turmoil

The global conflict in the Middle East is having a significant impact on the availability of oil to many countries, with Australia feeling the impact more than most countries. Fuel prices escalated during the first three weeks of the war (up to the end of March 2026), typically b...

Dissolved organic matter composition and mineral surface chemistry modulate organic retention and formation of mineral associated organic matter

The interaction between dissolved organic matter (DOM) and minerals governs OM stabilisation in soils. Heterogeneous composition of DOM and diverse mineral surface characteristics in soils make it challenging to determine reaction mechanisms at mineral-organic interfaces. To dete...

I Will Listen to Your Emotions, But I Will Hide My Own: People’s Different Strategies to Regulate Their Own Versus Others’ Emotions

Abstract: We can regulate our own and other people's emotions, but it is not clear whether we use the same strategies to regulate others’ emotions as we do to regulate our own. In three preregistered studies, we compared participants’ preferences for eight different emotion regul...

Shifting the Paradigm: From ‘Best Practice’ to ‘Best Beliefs’ for Autism Within Inclusive Early Childhood Education

Abstract This study explores the role of early childhood teachers’ beliefs in shaping inclusive practices for autistic children within Australian early childhood education and care (ECEC) settings. While national frameworks such as the Early Years Learning Framework (AGDE, 2022)...

Functional Assessment of a Constitutively Activating CASR Variant Causing Autosomal Dominant Hypocalcaemia

Abstract Context A rare cause of hypocalcaemia, autosomal dominant hypocalcaemia type 1 (ADH1) arises from a gain-of-function variant of the calcium sensing receptor gene (CASR). Objective Three patients from two unrelated families, presenting with hypocalcaemia and other biochem...

TrivalentAl Insertion into Layered-Oxide-DerivedPerovskite Oxynitrides for Defect-Controlled Dielectric Response

Abstract Al-containing perovskite oxynitrides, SrAl0.2M0.8O2.4N0.6 (M = Nb, Ta), were synthesized by ammonolysis of layered Sr5M4O15 precursors with α-Al2O3. This reaction demonstrates that the cation-insertion chemistry of layered-perovskite-derived oxynitrides can be extended t...

Stochastic generation of velocity fields to reproduce the energy spectrum in wall turbulence

Leveraging experimental measurements in rough-wall turbulent boundary layers that provided the spatial distribution and statistics of uniform momentum zones (UMZs), we previously introduced a stochastic model to generate two-dimensional modal velocity fields representative of the...

Optimizing Informed Consent for Australian Newborn Bloodspot Screening and Research: Consensus Workshop Insights and Recommendations

Informed consent is fundamental to Australian newborn bloodspot screening (NBS), but emerging genomic screening technologies pose new challenges to clinical care and research. Optimizing consent processes is necessary to support ethical practice and maintain public trust as NBS e...

Maximising the ‘co’ in co-design through facilitator actions: co-designers’ perspectives on what makes their participation in co-design meaningful

Co-design is a participatory approach to service development and research that is increasingly expected within the mental health sector. It involves end users being involved throughout a design process, not simply by providing opinions, but through shared decision making. Evidenc...

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive...

Enhanced Reactivation of Non-Pyrophoric Lanthanum-Modified AB2 Alloys for Hydrogen Storage

Abstract AB2 as hydrogen storage materials could provide an alternative path to compressed and liquid hydrogen for stationary applications. However, applications of these alloys are limited by the highly pyrophoric nature of AB2 powders once hydrogen-activated. Self-ignition and...