The University of Osaka

Therapeutic Efficacy and Safety of Intraperitoneally Administered 211At-Labeled Gold Nanoparticles for Peritoneally Disseminated Malignancies

Background/Objectives: Peritoneal dissemination of malignancies leads to poor prognoses, and no effective treatment currently exists. The difficulty of treating such malignancies is likely because systemically administered drugs cannot easily target malignant cells in the abdomin...

Structural inhomogeneity and inter-chromophore electronic/protein-mediated coupling in the Gloeobacter rhodopsin–canthaxanthin complex: Insights from resonance Raman spectroscopy

Microbial rhodopsins are photoreceptive membrane proteins that utilize retinal as a chromophore to absorb light and drive diverse photochemical functions. Recent studies have revealed that some microbial rhodopsins bind carotenoids in addition to retinal. The bound carotenoids ma...

Cryogenic time-division-multiplexed voltage control for scalable trapped-ion quantum processors

Trapped-ion quantum computers based on the quantum charge-coupled device architecture require on the order of ten trap electrodes per qubit, making the number of vacuum feedthroughs a bottleneck at the system scale. Time-division multiplexed (TDM)-based voltage control for trap e...

Efficacy and Safety of Stereotactic Body Radiation Therapy for Metastatic Bone Tumors in Clinical Practice

Abstract Background: The development of radiation techniques has demonstrated that stereotactic body radiation therapy (SBRT) effectively achieves good local control and long-term pain palliation for metastatic bone tumors. This study evaluated the efficacy and safety of SBRT for...

Type-II-like ultrafast demagnetization behavior in NiCo2O4 thin films

Rare-earth-free ferrimagnetic oxides are emerging as attractive platforms for investigating ultrafast spin dynamics. Here, we study the photoinduced magnetization dynamics of epitaxial NiCo2O4 (NCO) thin films by the time-resolved magneto-optical Faraday effect using two independ...

Submucosal Lidocaine Injection in Colonic Endoscopic Submucosal Dissection: A Single‐Center, Double‐Blind, Randomized Controlled Trial

OBJECTIVES: Colonic spasm is one of the major technical challenges encountered during colonic endoscopic submucosal dissection (ESD), impairing visualization of the dissection plane and scope maneuverability. Submucosal lidocaine injection may help to overcome this challenge. Thi...

Nipocalimab for warm autoimmune hemolytic anemia: results from the phase 2/3 randomized, double-blind ENERGY study

Warm autoimmune hemolytic anemia (wAIHA) is a rare, life-threatening disease characterized by autoantibody-mediated destruction of red blood cells with no approved treatments. Nipocalimab, an immunoselective neonatal Fc receptor blocker, reduces circulating IgG levels, including...

Structural insights into fosfomycin efflux by a streptococcal ABC transporter

ABSTRACT Gram-positive bacteria encode a broad array of ABC transporters that mediate substrate translocation across the cell membrane, with some contributing to their survival under environmental stresses such as antimicrobial exposure. While several of these transporters have b...

Treatment-dependent and independent prognostic value of inflammation-based nutritional indices in immune checkpoint inhibitor-based therapy for esophageal cancer

Abstract Background Phase III trials have established the efficacy of immune-based therapies for unresectable advanced or recurrent esophageal squamous cell carcinoma (ESCC). However, real-world evidence comparing regimens and clinically applicable prognostic biomarkers remains l...

Hip anteroposterior radiographic indices for effective osteoporosis screening in female patients undergoing total hip arthroplasty

Abstract Summary Osteoporosis in patients awaiting total hip arthroplasty remains undiagnosed. Although hip radiographic indices have been proposed for screening, they have not been compared. We compared the diagnostic accuracy of eight indices for osteoporosis. The canal–bone ra...

Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study

Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly...

Robotic repair of an esophago–left main bronchial fistula using a pedicled autologous pericardial patch and latissimus dorsi muscle flap: a novel technique after chemoradiotherapy for cT4b esophageal cancer

Abstract Once an esophago–airway fistula develops during chemoradiotherapy for cT4b esophageal cancer, further curative treatment is often precluded. We describe a robotic technique for closure of a large esophago–left main bronchial fistula using a pedicled autologous pericardia...

Multipolar Light-Matter Coupling in Nanostructures: From Ultrafast Radiative Decay to Forbidden Molecular Transitions

We review optical responses in the nano-to-bulk crossover, where bulk translational symmetry no longer applies and the long-wavelength approximation (LWA) often fails. In this regime, the response must be treated nonlocal, and a self-consistent solution of Maxwell’s equations and...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

Parkinsonism-like delayed neurotoxicity after idecabtagene vicleucel therapy for multiple myeloma: clinicopathological, cerebrospinal fluid, and autopsy analyses

Not available.

Circadian temperature compensation is intrinsically linked with metabolism and redox signaling

Abstract Circadian rhythms are a universal property of organisms, and a defining property of these oscillators is the ability to maintain a precise period at different temperatures. Indeed, the discovery in the 1950s of this property, known as “temperature compensation,” was a wa...

Boundedness of Composition Operators in Orlicz–Morrey Spaces

ABSTRACT In this paper, we investigate the necessary and sufficient conditions for the boundedness of composition operators on Orlicz–Morrey spaces. Our results encompass Lebesgue and generalized Morrey spaces as special cases. In addition, we characterize the boundedness of comp...

Multi‐fidelity Monte Carlo fusion for BNCT dose calculation using a dual‐branch network

BACKGROUND: Boron neutron capture therapy (BNCT) is a binary radiotherapy that selectively kills tumor cells. Its clinical implementation relies on Monte Carlo (MC)-based treatment planning systems, which are time-consuming and limit clinical workflow efficiency. PURPOSE: To addr...

Clonal evolution from primary to locally recurrent rectal cancer reveals recurrence-acquired potentially actionable alterations in treatment-naïve tumors

BACKGROUND: Locally recurrent rectal cancer (LRRC) occurs in 6-10% of patients after curative surgery. It is often regarded as a simple residual disease, yet accumulating evidence suggests that LRRC is biologically distinct from primary tumors. Clonal evolution in matched primary...

Thermomechanical Properties of Natural Rubber/OPEFB Composites With Hybrid Latex–Starch Coupling Agent

ABSTRACT Natural rubber composites remain essential for industrial applications in Indonesia, particularly in tire manufacturing, where improved rigidity and strength are required. This study investigates the use of oil palm empty fruit bunch fiber as a sustainable filler to enha...