The University of Osaka

Tight-binding analysis of the structural dimension dependence of the optical bandgap in ZnSe/ZnS core-shell quantum dots

The structural dimension dependence of the optical bandgap in ZnSe/ZnS core–shell quantum dots is examined using a valence force field model combined with an atomistic tight-binding approach. We demonstrate that increasing shell thickness enhances compressive strain within the Zn...

Manufacturing Paradigm III—From Conception to the Academic Frontier

The theory of the “three paradigms of manufacturing development” is derived from a systematic analysis of the evolution of manufacturing precision and controllable feature size. It posits that Manufacturing Paradigm III is grounded in quantum theory as its new theoretical foundat...

Cord Blood‐Derived Fibroblast Activation Protein‐Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo

ABSTRACT Cancer‐associated fibroblasts (CAFs) have been recognized as key contributors to tumor progression. Chimeric antigen receptor (CAR) T‐cell therapy targeting fibroblast activation protein (FAP), a marker of CAFs, has gained attention and is being evaluated in both preclin...

Diboron‐Embedded Heteroacenes With Systematically Varied Central π‐Skeletons and Fusion Modes

ABSTRACT Diboron‐embedded heteroacenes with systematically varied central π‐skeletons and fusion modes were synthesized via one‐pot cyclative borylation using benzene, thieno[3,2‐ b ]thiophene, or dithieno[3,2‐ b :2′,3′‐ d ]thiophene cores, affording six derivatives with C 2h or...

Controlling site-selectivity in C—C bond formation of cyclohexa-2,4-dienones and ortho -quinones

Abstract C–C bond formation involving phenol-derived oxidative intermediates has steadily advanced in recent years. This review focuses on the site-selectivity of C–C bond formation in cyclohexa-2,4-dienones and ortho-quinones generated via oxidative transformations of phenols. T...

Thalamic projections from the cerebellar nuclei receiving proprioceptive signals from the jaw muscles in rats

The neural mechanisms involved in transmission of proprioceptive information from muscles are not fully understood. Proprioceptive signals from jaw-closing muscle spindles (jcms) are relayed to the supratrigeminal nucleus (Su5), and, then, from the Su5 to the thalamus including t...

Ultrahigh flow strength in shocked nanopolycrystalline diamond

Extreme pressures and temperatures create conditions that allow even hard and brittle materials to flow plastically. Despite extensive research, the limits of flow strength under such conditions remain uncertain, and the mechanisms driving deformation at the relevant stresses are...

In vitro induction of human germinal center B cells

During antibody responses, germinal centers (GCs) act as a key site for somatic hypermutation (SHM) and affinity maturation of B cells. However, their lymphoid tissue localization has made experimental manipulation of human germinal center B (GCB) cells difficult. Here, we descri...

Prognostic value of AI-derived probability of interstitial lung abnormalities and interstitial lung disease in patients with esophageal cancer

Abstract Purpose To investigate the association between AI-derived probability of interstitial lung abnormalities (ILA), including interstitial lung disease (ILD), and prognosis in an esophageal cancer cohort re-evaluated according to the 2025 American Thoracic Society (ATS) Clin...

Spatial Control of Spontaneous Orientation Polarization for Efficient Charge Separation in Organic Photovoltaics

ABSTRACT Spontaneous orientation polarization (SOP) offers a unique approach to generating internal electric fields in organic photovoltaics (OPVs). However, in conventional high‐performance OPVs based on bulk heterojunction architectures, the complex nanoscale morphology makes i...

Expanding the genotypic and phenotypic spectrum of PGAP1 deficiency: clinical and functional insights from 15 patients

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are essential for neuronal development, synaptic organization and signaling. Defects in GPI-anchor biosynthesis or remodeling cause rare neurodevelopmental disorders, including post-GPI attachment to proteins 1 (PGAP1) defi...

Fusion of a non-specific DNA-binding domain enhances Cas12a trans-cleavage for robust nucleic-acid diagnostics

CRISPR–Cas12a underlies powerful genome-editing and nucleic-acid detection technologies, yet its performance is limited by inefficient target engagement and low catalytic turnover, particularly at low target abundance and elevated temperatures. Here, we report a modular protein-e...

Control of fatigue-critical defect size by pulsed current parameters in GTAW-based wire arc additive manufacturing of Ti-6Al-4V

Abstract Wire arc additive manufacturing (WAAM) can suffer from lack of fusion (LoF) and gas porosity, which degrade fatigue performance. Although pulsed arc current has been widely used for defect reduction in welding, its mechanistic role in controlling molten-pool dynamics and...

Ground states of the defocusing nonlinear Schrödinger equation with a point interaction in dimensions 2 and 3

Abstract This paper is concerned with ground states of the defocusing nonlinear Schrödinger equation with a point interaction, $$ \textrm{i} \partial _t \psi = -\Delta _\alpha \psi + \psi |\psi |^{p - 2} \quad \text {in} \quad \mathbb {R} \times \mathbb {R}^N, $$ i ∂ t ψ = - Δ α...

Impact of Inhibitor Size and Flexibility on the Binding Pathways to c-Src Kinase

Abstract The conformational plasticity of protein kinases poses a challenge for inhibitor design, motivating the use of molecular dynamics (MD) simulations to study their dynamic binding processes. While conformational changes are increasingly discussed, the impact of drug compou...

A multicenter phase II trial of ramucirumab plus irinotecan for early recurrence of gastric cancer during or after adjuvant chemotherapy with docetaxel plus S-1 therapy: the RAMIEL trial (OGSG1901)

Abstract Background There is currently no established chemotherapy regimen for early recurrence of pathological stage III gastric cancer (GC) following adjuvant chemotherapy with docetaxel plus S-1 (DS) after D2 gastrectomy. We aimed to evaluate the efficacy and safety of ramucir...

Complement profiling and neutrophil single-cell analysis reveal inflammation via the classical complement pathway in Behçet’s syndrome

Behçet’s syndrome (BS) is a systemic immune-mediated disorder characterised by recurrent mucocutaneous, skin, and ocular inflammation, with severe neurological, vascular, or gastrointestinal involvement in some individuals. Although neutrophilic inflammation is considered central...

Smartphone step-count patterns and later QMCOO-defined frailty-related risk

Smartphone steps offer low-burden signals. Their incremental value for later frailty-related risk defined by the Questionnaire for Medical Checkup of Old-Old (QMCOO) remains uncertain. We analyzed users of Osaka’s Asmile app. Step-count features from November–December 2024 were r...

Effect of thermal modeling assumptions on prediction accuracy and computational efficiency in laser-arc hybrid welding simulation

Laser-arc hybrid welding (LAHW) imposes steep, localized thermal gradients demanding computationally expensive thermo-elastic-plastic (TEP) finite element analysis. To quantify the trade-off between physical fidelity and computational efficiency, three TEP models of LAHW on a 300...

The parent bodies of Ryugu and Ivuna formed before those of other carbonaceous chondrites

Most carbonaceous chondrite (CC) meteorites contain abundant chondrules, millimeter-scale spherical inclusions of previously molten material. Ivuna-type carbonaceous chondrites (CIs) do not contain chondrules, nor do samples of the carbonaceous asteroid Ryugu. CIs and Ryugu share...