The University of Osaka

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

The parent bodies of Ryugu and Ivuna formed before those of other carbonaceous chondrites

Most carbonaceous chondrite (CC) meteorites contain abundant chondrules, millimeter-scale spherical inclusions of previously molten material. Ivuna-type carbonaceous chondrites (CIs) do not contain chondrules, nor do samples of the carbonaceous asteroid Ryugu. CIs and Ryugu share...

Discovery of an intrinsic non-Hermitian phase transition in a bulk condensed-matter system

Across regular phase transitions, systems remain in thermal equilibrium. However, when a system is driven far from equilibrium, non-Hermitian phase transitions may arise where the dynamical behavior—rather than steady properties—undergoes a qualitative change at a critical, so-ca...

Hierarchical Electronic Transport in Giant Mixed-Valence {Mo154} Rings Revealed in Anhydrous Single-Molecule-Layer Networks

Abstract Polyoxometalates (POMs) are redox-active metal–oxo clusters of central interest in molecular and materials chemistry. The giant mixed-valence {Mo154} ring, built from 14 repeating subunits, is a prototypical system expected to exhibit rich electronic functionality; howev...

A collagen orientation switch reshapes fin architecture

Fibrillar-collagen architecture is a fundamental determinant of vertebrate tissue morphology; yet, its organizational principles remain poorly understood because collagen structures are challenging to visualize in vivo . Actinotrichia, the fibrillar-collagen structures in fish fi...

Japanese translation of lindop parkinson’s disease mobility assessment (LPA): validity and reliability study

Abstract Introduction The Lindop Parkinson’s Disease Mobility Assessment (LPA) is a Parkinson’s disease (PD)-specific clinical scale. The LPA was designed to assess core functional mobility in rehabilitation, including gait and bed mobility. This study aimed to develop a Japanese...

Determinants of donation intentions on second-hand trading platforms: the roles of psychological ownership, empathy and product layout

Purpose While loss aversion has long served as the dominant explanation for the endowment effect, a growing body of research proposes that ownership fosters a cognitive and affective linkage between the object and the self, often termed the “possession-self connection,” thereby e...

Age and sex estimation from Japanese femoral computed tomographic images using foundation models

OBJECTIVE: This study evaluated the feasibility and performance of a deep learning-based multitask framework for estimating sex and age using femoral CT images in a Japanese population. MATERIALS AND METHODS: Postmortem CT (PMCT) data from 1,489 Japanese individuals (1,003 males,...

Ternary Liquid-Crystalline Mixture Showing Broad Antiferroelectric Smectic CA* and Glassy Hexatic Smectic XA* Phases

Abstract A ternary liquid crystalline mixture was designed to obtain a tilted hexatic smectic phase in the glassy state. Structural, electro-optic, and dielectric properties of the mixture are investigated, and selected measurements are also performed for its pure components. In...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Development of the Japanese version of the Manchester short assessment of quality of life (MANSA) among people with self-reported severe mental illness

The Manchester Short Assessment of Quality of Life (MANSA) is a quality-of-life (QOL) instrument developed for people with mental illness. This study aimed to develop a Japanese version of the MANSA for people with severe mental illness (SMI) and examine associations between indi...

Autoparallelity of quantum statistical manifolds in light of quantum estimation theory

In this paper we study the autoparallelity w.r.t. the e-connection for an information-geometric structure called the SLD structure, which consists of a Riemannian metric and mutually dual e- and m-connections, induced on the manifold of strictly positive density operators. Unlike...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their re...

Positive selection of IgG over IgM plasma cells through BCR isotype–specific antigen presentation and signaling

During a primary immune response, B cells can undergo isotype switching from an immunoglobulin M (IgM) B cell receptor (BCR) to an IgG BCR. B cells that have switched to IgG give rise to more bone marrow long-lived plasma cells (PCs) compared with those expressing IgM, but how BC...

Dynamic capacity investment and debt financing

It is common for companies to conduct multiple capacity expansions in a growing market. In this article, we study how firms make optimal multi-stage investment timing, scale, and capital structure decisions in the context of multiple growth options and existing assets. We show th...

Safety design approach for sodium-cooled fast reactor coupled to thermal energy storage system with sodium-molten salt heat exchanger improving heat transfer performance

A sodium-cooled fast reactor (SFR) can make flexibility with variable renewable energy by coupling a thermal energy storage (TES) system with molten salt. One of technical issues for the SFR coupled with TES is a heat exchanger (HX) between sodium and molten salt. In particular,...

Age-dependent sex differences in acute kidney injury among patients with chronic kidney disease

Patients with chronic kidney disease (CKD) are susceptible to acute kidney injury (AKI), which worsens clinical prognosis. Sex differences in AKI incidence and subsequent kidney prognosis remain uncertain in CKD. This multicenter, retrospective cohort study analyzed outpatients w...

MRI Proton Density Fat Fraction as a Biomarker of Marrow Recovery Following Organ‐Sparing Total Marrow Irradiation in Sickle Cell Disease

BACKGROUND: Noninvasive quantitative assessment of marrow recovery after curative therapies such as total marrow irradiation (TMI) and bone marrow transplantation (BMT) remain poorly defined, particularly in sickle cell disease (SCD). PURPOSE: To evaluate MRI-derived proton densi...

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

ABSTRACT Background Oral squamous cell carcinoma (OSCC) progression is accompanied by bone invasion. Therefore, maintaining oral function is necessary to regulate tumor progression. Also, interleukin-12 (IL-12), a well-known anti-tumor cytokine, can suppress osteoclast differenti...

Evaluation of joint quality and shear performance of high-frequency induction-heating riveting

This study evaluates the joint quality and shear performance of riveted joints fabricated using induction heating (IH) through experiments and simulations. Riveting specimens fabricated using three IH processes (IHA, IHB, and IHC) were compared with coke-heating (CH) specimens. T...