Tehran University of Medical Sciences

Association between dietary phytochemical index and pancreatic steatosis in patients with common bile duct stones

The dietary phytochemical index (DPI) may protect against pancreatic steatosis (PS), but evidence is limited. This study examined the association between DPI and PS risk. This case-control study included 278 patients with common bile duct stones at Taleghani Hospital, Tehran, bet...

A hemicrania continua‑like headache as an early signal of anti‑NMDA receptor encephalitis: a case report

Trigeminal autonomic cephalalgia (TAC) syndromes, although rare in the spectrum of headache disorders, are of great importance to recognize, because they can be debilitating and may be linked to potentially serious underlying causes. We present a patient with a TAC-like headache,...

Global prevalence of colistin resistance, mcr gene variants, and sequence types in Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Stenotrophomonas maltophilia: a systematic review and meta-analysis

Abstract Background Due to the increasing prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria, colistin has become an important therapeutic option. However, the rapid emergence of resistance to this antimicrobial agent, mediated by mechanisms such...

Incremental Prognostic Value of CT Indices Derived from Midline Shift and Hematoma Thickness in Acute Subdural Hematoma

Background: In acute subdural hematoma (ASDH), early risk stratification relies heavily on hematoma thickness (HT) and midline shift (MLS). Composite indices derived from these measures have been proposed to better characterize mass effect, but their incremental prognostic value...

Association between preoperative hypoalbuminemia and postoperative complications in spinal fusion surgery: an approach- and spinal level-stratified meta-analysis

While hypoalbuminemia is recognized as a risk factor for adverse postoperative outcomes in various surgeries, its specific impact on spinal fusion outcomes has not been systematically synthesized. This meta-analysis aimed to evaluate the association between preoperative hypoalbum...

Design of a prediction system for intravenous immunoglobulin resistance in hospitalized Kawasaki disease patients with artificial intelligence based on machine learning

Machine Learning (ML) algorithms are widely used as a prediction tool in medicine to support clinical decisions. In this study, the machine learning methods are used to investigate IVIG resistance in Kawasaki disease in a referral center of Iran. This is a retrospective cross-sec...

Comparison of novel visceral adiposity indices with body mass index for identification of prevalent diabetes: findings from the 2021 Iran STEPS survey

Diabetes mellitus (DM) is a major contributor to global morbidity and mortality, particularly in developing regions. Effective identification of high-risk individuals is crucial for targeted prevention and resource allocation. This population-based study aimed to compare the asso...

Comparison of adding magnesium sulfate versus dexmedetomidine to intrathecal bupivacaine in patients undergoing total knee arthroplasty: a randomized double-blind clinical trial

Total knee arthroplasty is frequently associated with substantial postoperative pain, and spinal anesthesia with intrathecal bupivacaine is commonly used to provide effective perioperative analgesia. Adjuvants such as magnesium sulfate and dexmedetomidine may enhance block qualit...

Frequency of Human Brucellosis Complications in West Asia: A Systematic Review and Meta‐Analysis

ABSTRACT Background Brucellosis is a multi‐systemic zoonotic infection. The West Asia/Middle East region is an important global hotspot for brucellosis. This systematic review and meta‐analysis aimed to aggregate and synthesize all the available evidence regarding the complicatio...

Dual topical therapy with doxepin and allopurinol mouthwash for severe methotrexate-induced oral mucositis: a pediatric case report

High-dose methotrexate (HD-MTX) is a cornerstone of chemotherapy for pediatric osteosarcoma but frequently induces severe oral mucositis, a dose-limiting toxicity characterized by painful ulceration and impaired oral function. While standard supportive care includes leucovorin re...

The association between perceived social support and glycemic status transitions: a 3-year longitudinal study of Iranian adults

This three-year longitudinal study investigates the association of Perceived Social Support and its subscales with changes in blood-glucose status among Iranian adults. In a three-year cohort of 1,458 Iranian adults, perceived social support was measured with the 12-item Iranian...

Temporal trends and patterns of pre-hospital emergency medical service utilization in Yasuj, Southwest Iran: a four-year registry-based cross-sectional study

Pre-hospital Emergency Medical Services (EMS) are essential for the timely management of traumatic injuries and acute medical emergencies. This study evaluated temporal trends, epidemiological characteristics, and utilization patterns of pre-hospital EMS missions in Yasuj, Southw...

Physical exercise as a therapeutic strategy in animal models of Alzheimer's disease: Molecular, behavioral, and histopathological evidence

Background Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide, imposing a substantial economic burden. As the population ages and cases rise, interest in early identification, prevention, and treatment has intensified. After establishing that patholog...

Hematologic Indices of Hemoglobin D Co-Inheritance with α and β Thalassemia: A Comparative Study of 202 Patients

To characterize the hematologic effects of hemoglobin D (HbD) alone and in the presence of co-inherited α- or β-thalassemia, and to quantify associations with anemia, microcytosis, and hypochromia relative to normal-CBC controls. This retrospective comparative study included 202...

Evaluation of CD10 Expression in Endometrial Carcinoma: A Systematic Review.

Background & Objective: CD10 is a membrane-bound metalloproteinase that plays a role in tumor progression and differentiation. Its diagnostic significance in endometrial carcinoma, especially in distinguishing between histological subtypes and invasion patterns, is still being st...

Quantitative Susceptibility Mapping‐Based Characterization of Lesion Heterogeneity in Multiple Sclerosis

ABSTRACT Background Quantitative susceptibility mapping (QSM) characterizes multiple sclerosis (MS) lesions through susceptibility changes related to iron and myelin. However, the prevalence, regional distribution, and relationship of QSM‐defined lesion subtypes with choroid plex...

Illness perception in advanced heart failure: a hermeneutic phenomenological study

Heart failure (HF) is a chronic, progressive condition that profoundly affects patients’ physical functioning and their psychological, social, and existential well-being. Beyond its clinical manifestations, patients continuously interpret and assign meaning to their illness, and...

Brain MRI Changes Following Continuous Positive Airway Pressure Therapy in Adults with Obstructive Sleep Apnea: A Systematic Review

Abstract Study Objectives Obstructive sleep apnea (OSA) is associated with structural, microstructural, functional, vascular, and metabolic brain alterations. Continuous positive airway pressure (CPAP) is the first-line treatment for OSA, but whether OSA-related abnormalities on...

Combination of CIK cells with oncolytic viruses: A potential Immunovirotherapy strategy for the treatment of solid tumors

Cytokine-induced killer (CIK) cells represent a promising cellular immunotherapy, characterized by potent cytotoxicity, major histocompatibility complex (MHC)-unrestricted tumor recognition, and ease of ex vivo expansion. Despite these properties, their clinical efficacy against...

Situation analysis of breast cancer screening in Iran: a mixed-methods study

Breast cancer is the leading cause of cancer death among Iranian women, yet national screening remains opportunistic and unevenly implemented. This study assessed Iran’s breast cancer screening system to identify gaps and opportunities for establishing an organized, population-ba...