Tehran University of Medical Sciences

Barriers and facilitators of vector-borne diseases knowledge translation: a scoping review

Vector-borne diseases (VBDs) such as leishmaniasis, dengue, and malaria continue to pose major public health challenges, driven by environmental, socioeconomic, and climatic factors. Although numerous studies have generated valuable evidence, research findings are rarely translat...

Mechanistic insights into the inhibition of insulin amyloidogenesis and associated toxicity by the p. M14L variant of exenatide

Insulin fibrillation and the subsequent formation of toxic amyloid aggregates are significant challenges in therapeutic development and are associated with cellular proteotoxicity. In this research, we explored how the p.M14L exenatide variant affects the formation of insulin amy...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Short‐Term Clinical Comparison of Scapular Stabilization With and Without Added Kinetic‐Chain Exercises on Pain, Scapular Kinematics, and Upper‐Extremity Function in Overhead Athletes With Subacromial Pain Syndrome: A Randomized Controlled Trial

BACKGROUND AND PURPOSE: Scapular stabilization exercises are commonly used in the rehabilitation of athletes with subacromial pain syndrome (SAPS) and scapular dyskinesis. Whether supplementing scapular stabilization with kinetic-chain exercises provides greater short-term benefi...

Contemporary global prevalence and genotype distribution of human papillomavirus among female sex workers, 2015–2025: an updated systematic review and meta-analysis

Abstract Background Female sex workers experience disproportionate exposure to human papillomavirus (HPV), but estimates of HPV prevalence and genotype distribution vary according to geography, specimen type, diagnostic method, and genotype coverage. This updated systematic revie...

Bifidobacterium longum prevent the progression of colon cancer via inhibiting metastasis and angiogenesis

Colorectal cancer (CRC) is one of the most common reasons for cancer-related death, and both angiogenesis and metastasis have established roles in CRC progression. Recent findings suggest that probiotics, like Bifidobacterium longum, are capable of suppressing anti-cancer activit...

From knowledge to action: health literacy and health-promoting behaviors in parents of autistic children, a cross-sectional study in Iran

Children with Autism Spectrum Disorder (ASD) depend on their parents for their health and well-being, especially in Iran where formal services for children with ASD are limited and families play a central role in daily care. The most effective diagnostic and therapeutic intervent...

Low serum levels of C1q/TNF-related protein-14 (CTRP14) in newly diagnosed type 2 diabetes patients

To measure serum C1q/tumor necrosis factor (TNF)-related proteins (CTRPs) levels in newly diagnosed, treatment-naïve men with type 2 diabetes mellitus (T2DM) and healthy controls, and to investigate their associations with metabolic parameters, the presence of T2DM and insulin re...

Unveiling the antiviral activity of Adiantum capillus-veneris L. against influenza A(H1N1)

The influenza virus poses a global health threat, with current management involving antiviral drugs and annual vaccination, although challenges of resistance exist. Herbal medicine, particularly Adiantum capillus-veneris L., traditionally used for respiratory diseases, shows anti...

Feedback loops as a core driver: rethinking organizational readiness for knowledge translation in Iranian medical universities

Bridging the gap between research evidence and healthcare decision-making, knowledge translation (KT) is a critical process. However, despite advances in research production, many universities in low- and middle-income countries face significant challenges in implementing KT due...

Evaluating the Role of Exosome Therapy in Reproductive Aging:A Narrative Review of Recent Advancements.

INTRODUCTION: Exosome therapy shows promise as a non-hormonal treatment to restore ovarian function and combat reproductive aging. This review aims to explore recent advances, mechanisms, and clinical potential of exosome therapy in reproductive aging. METHODS: This narrative rev...

From Classroom to Clinic: A Qualitative Study on Newly Graduated Nurses' Transition to Practice.

BACKGROUND: The global nursing shortage and high turnover rates among newly graduated nurses (NGNs) pose significant challenges to their transition into professional roles. Understanding NGNs' experiences is crucial for identifying the factors contributing to turnover and develop...

Computational multi-omics integration in neurocognitive disorders from machine learning to graph-based approaches

Neurocognitive disorders (NCDs) pose a major global health challenge. This review summarizes computational methods for multi-omics data integration in NCD research, including conventional machine learning, deep learning, and graph-based approaches. We highlight their strengths, l...

Patient- and care-related factors associated with central line-associated bloodstream infection in adult intensive care units: a retrospective matched case-control study at a tertiary referral center

Central line-associated bloodstream infection (CLABSI) is an important preventable healthcare-associated infection in intensive care units (ICUs). This study evaluated patient- and care-related factors associated with CLABSI and described the causative microorganisms in adult ICU...

Modeling organizational capacity development through faculty development programs

INTRODUCTION: Faculty development programs are widely recognized for enhancing individual academic competencies in higher education. However, their systemic influence on organizational capacity, especially within complex academic institutions, remains underexplored. This study ai...

A multicenter cross-sectional study of job satisfaction and associated factors among nurses in selected hospital settings in Germany, Iran, and Canada

This study aimed to examine job satisfaction and its associated factors among nurses working in selected hospital settings in Germany, Iran, and Canada. A multicenter cross-sectional study was conducted from April 2017 to June 2019 across four tertiary-care teaching hospitals. A...

Ultra-processed food consumption (NOVA index) and the odds of diabetic nephropathy in women: a case-control study

diabetic nephropathy (DN) is a major complication of diabetes mellitus associated with increased morbidity and mortality. Dietary factors, particularly unhealthy food consumption, may contribute to kidney dysfunction. This study aimed to investigate the association between the NO...

From Bench to Bedside: A Critical Appraisal of Somatostatin Receptor Antagonists in the Theranostic Management of Neuroendocrine Neoplasms

Neuroendocrine neoplasms are increasingly assessed using somatostatin receptor (SSTR) antagonists as an alternative to conventional agonists in molecular imaging and targeted radiopharmaceutical therapy. Radiolabeled SSTR antagonists, such as [68Ga]Ga-NODAGA-JR11 and [68Ga]Ga-NOD...

Typology of learning styles in medical students: a systematic review of 33 countries

Understanding students' learning styles is crucial for guiding the teaching–learning process according to their individual needs and preferences, and for creating effective pedagogical situations. Therefore, this systematic review aimed to identify learning styles in medical stud...

Sex disparities in cardiovascular risk among older adults: insights from the Tehran cohort study (TeCS)

Cardiovascular disease (CVD) is the leading cause of death in Iran and is expected to increase with population aging. However, sex-specific data on CVD risk in older adults are limited. This study examined differences between men and women in major CVD risk factors, and predicted...