Tehran University of Medical Sciences

Evaluation of changes in quality of life, life satisfaction, and anxiety following in-person and virtual dignity therapy in patients with heart failure: a quasi-experimental controlled study

Dignity therapy is a life review intervention that can help reduce existential and spiritual distress in patients with heart failure. However, there is limited evidence comparing the two delivery modes (in-person and virtual) of this intervention. This study aimed to evaluate cha...

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

The tumor microenvironment (TME) is a complex and heterogeneous milieu encompassing biological and biochemical events and diverse physical, chemical, and mechanical interactions between tumor and stromal cells. This heterogeneity plays a pivotal role in regulating tumor progressi...

Personalized Cine Cardiac MRI Protocol Optimization Using a Retrieval‐Augmented Large Language Model: A Prospective Comparison With Technologist‐Optimized Protocol

ABSTRACT Background Cine cardiac magnetic resonance imaging (MRI) protocols are typically based on static templates, which may not optimally address individual patient limitations such as arrhythmia or limited breath‐hold capacity. Purpose To test whether an artificial intelligen...

Association between salivary alkaline phosphatase levels and periodontal disease: a systematic review and meta-analysis

This updated meta-analysis evaluated salivary alkaline phosphatase (ALP) levels in individuals with gingivitis and periodontitis compared to periodontally healthy individuals. The review followed PRISMA guidelines and was registered in PROSPERO (CRD420251273461). Searches were co...

Frequency of positive margins and predictors in breast-conserving surgery in developing countries

Achieving negative surgical margins in breast-conserving surgery (BCS) is crucial due to the risks linked to positive margins, such as the need for reoperation and elevated local recurrence rates. Limited data exist about positive margins after BCS in developing countries, includ...

Fronto-temporal transcranial direct current stimulation reduces symptoms in treatment-resistant schizophrenia: a randomized sham-controlled trial

Treatment-resistant schizophrenia (TRS) remains a major clinical challenge, with limited response to pharmacotherapy. Transcranial direct current stimulation (tDCS) has emerged as a potential adjunctive treatment, although evidence regarding its efficacy remains inconsistent. To...

Familial nemaline myopathy and multiple sclerosis: a case report exploring a novel co-occurrence with familial clustering

Nemaline myopathy (NM) and multiple sclerosis (MS) are distinct disorders with different genetic or epigenetic characteristics, and their co-occurrence has not been priorly documented. We report a 40-year-old male with a notable familial history of both NM and MS who was diagnose...

Combination of Empagliflozin and Resveratrol Mitigates Hepatic Steatosis via Attenuation of Inflammation and Promotion of Adipose Tissue Browning in High‐Fat Diet‐Fed C57BL / 6J Mice

ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major hepatic complication of obesity with a complex pathogenesis. This study aims to investigate the combined effects of empagliflozin (EMPA) and resveratrol (RSV) treatment on obesity‐associated MASL...

HER2-Low Breast Cancer: A Review of Epidemiology, Diagnostic Challenges, Targeted Therapies, and Clinical Outcomes

Background: Breast cancer is the most common malignancy among women. The HER2-low subgroup represents one of its prevalent subtypes; however, due to its unique characteristics, it presents challenges in diagnosis and treatment, complicating clinical management. This narrative rev...

Long‐term clinical outcomes of stem cell‐based interventions in Crohn's‐related perianal fistula: A systematic review and meta‐analysis

BACKGROUND: Perianal fistulas are a debilitating complication of Crohn's disease, frequently refractory to conventional medical and surgical therapy. Stem cell-based interventions, particularly mesenchymal stem cells (MSCs), have emerged as a promising therapeutic alternative, ye...

Machine learning-assisted design of a novel crocin-loaded poloxamer 407/hyaluronic acid in situ forming hydrogel for endometriosis treatment: in vitro characterization and in vivo efficacy evaluation

Our study focused on fabricating and characterizing a crocin in situ forming hydrogel for endometriosis treatment. An artificial neural network (ANN)-based machine learning (ML) approach was employed to determine the effects of poloxamer 407 (P407) and hyaluronic acid (HA) concen...

Stress Distribution Pattern in Implant-Assisted Removable Partial Denture (IARPD): A 3D Finite Element Analysis

Abstract Removable partial dentures (RPDs) held in place by clasps have become a favored option for treating patients with partial tooth loss. However, these dentures have their drawbacks, including the issue of frequent displacement, which can lead to patient dissatisfaction and...

Association between dietary fatty acids and all‐cause mortality in patients with cirrhosis: A cohort study

Abstract Liver cirrhosis imposes a substantial global burden, with complications driving high mortality. Diet is pivotal in managing liver disease progression and cirrhosis‐related death. This study investigated associations between total fat intake, specific dietary fatty acid s...

Neuroprotective Effects of Nanocurcumin in Spinal Cord Injury: Modulation of Inflammatory and Inflammasome-Associated Signaling in an Integrated In Vivo , In Silico , and Machine-Learning Study

Spinal cord injury (SCI) triggers secondary neuroinflammatory and inflammasome-associated responses that contribute to tissue damage and functional impairment. This study evaluated nanocurcumin in experimental SCI using integrated experimental, computational, and exploratory mach...

Childbearing attitudes and associated factors among married couples in Mazandaran Province, Iran: a cross-sectional study

Abstract Background Childbearing attitudes are influenced by various demographic, socioeconomic, and psychosocial factors. This study aimed to examine factors associated with childbearing attitudes among married couples in Mazandaran Province, Iran. Methods A cross-sectional anal...

The Role of Ultra‐Low‐Dose Naloxone as an Additive in Anesthesia and Nerve Block: A Systematic Review

ABSTRACT Background and Aims In anesthesia and analgesia, opioids alone or in combination with local anesthetics (bupivacaine, lidocaine, and ropivacaine) have been investigated to prolong peripheral nerve blocks. Ultra‐low‐dose naloxone administration in local anesthetic solutio...

Exploring medical interns’ perceptions and satisfaction with task-based microlearning in an otolaryngology rotation: a mixed-methods study

Abstract Background The integration of traditional and modern educational approaches in contemporary curricula, particularly in medical education, is becoming increasingly necessary. Medical schools and healthcare institutions are seeking to enhance the effectiveness and efficien...

How internationalization in pharmacy education is delivered: A scoping review of experiences and lessons learned

Background In pharmacy education, global outreach initiatives take diverse forms, each with distinct advantages and challenges. This scoping review examines the literature on international collaborations among pharmacy institutions, highlighting key outcomes, challenges, and insi...

Barriers and facilitators of vector-borne diseases knowledge translation: a scoping review

Vector-borne diseases (VBDs) such as leishmaniasis, dengue, and malaria continue to pose major public health challenges, driven by environmental, socioeconomic, and climatic factors. Although numerous studies have generated valuable evidence, research findings are rarely translat...