Tehran University of Medical Sciences

From chronic disease burden to cognitive decline: a systematic review of multimorbidity in older adults

Abstract Background Multimorbidity is common in older adults and has been associated with adverse cognitive outcomes. However, findings remain heterogeneous because of differences in multimorbidity definitions, cognitive measures, and study designs. This review aimed to synthesiz...

Maternal oral health indicators during pregnancy and childhood allergic outcomes up to three years: a retrospective analysis of a prospective cohort study

Maternal oral health during pregnancy may be associated with offspring allergic outcomes, but evidence linking specific oral health indicators to childhood allergy is limited. We examined associations between maternal oral health indicators during pregnancy and questionnaire-asce...

Changes in intravenous pantoprazole utilization following two sequential interventions in a tertiary referral hospital

Objectives Intravenous (IV) pantoprazole is an effective proton pump inhibitor (PPI) with certain evidence-based indications for acid-related disorders. However, many studies demonstrated the considerable inappropriate administration of IV pantoprazole, resulting in adverse drug...

Strategic analysis of online pharmacy implementation: a scoping review and SWOT-based framework

The expansion of online pharmacies, a key development in digital health, has influenced both patient care and health system operations. Despite their benefits, these platforms face regulatory, infrastructural, and safety challenges. This study aimed to provide a strategic overvie...

Assessing human reliability and estimating evacuation time in hospital emergencies: A Bayesian network and Petri net approach

The complex operational environment of hospitals, characterized by varying patient mobility levels, inconsistent staffing patterns, and resource distribution across departments, creates unique challenges for evacuation planning. This study employs Bayesian networks (BN) to enhanc...

Clinical outcomes of low versus high intensity laser therapy in patients with subacute carpal tunnel syndrome: A randomized, single-blinded, controlled trial

A common entrapment of median nerve that causes pain, numbness, and functional impairment is called Carpal Tunnel Syndrome (CTS). Laser therapy is a noninvasive intervention for neural repair and pain modulation, but comparative evidence between Low-Level Laser Therapy (LLLT) and...

Geometric and morphological assessment of structurally normal tricuspid aortic valves based on body surface area using 3D transesophageal echocardiography

Aortic valve geometry is a key parameter for aortic valve repair, which serves as a surgical alternative to valve replacement for aortic insufficiency treatment. Individuals with different body sizes may exhibit varying geometric parameters of the aortic valve. This study aims to...

Factors affecting adolescent participation in HIV/AIDS prevention services provided by Non-Governmental Organizations in Iran

One of the best ways to reach teenagers with high-risk behaviors and encourage them to use HIV/AIDS prevention services is to seek help from non-governmental organizations (NGOs). Therefore, in Iran, some NGOs active in this field were formed under the name of Adolescent Well-bei...

Design, synthesis, and biological evaluation of novel 4,5-diaryl-1,2,3-thiadiazole derivatives: anticancer activity and molecular docking studies

Malignancies remain a major global health challenge. Microtubule-targeting agents (MTAs) have emerged as a significant therapeutic class, effectively suppressing cancer cell proliferation by interfering with the normal dynamics of microtubules. Combretastatin, particularly combre...

Development and preliminary psychometric evaluation of the postpartum sexual and reproductive health questionnaire (PSRHQ) in Iranian women

Abstract The postpartum period is a critical phase in a woman’s life. This study aimed to develop and psychometrically evaluate a questionnaire designed to assess sexual and reproductive health among postpartum women. This exploratory sequential mixed-method study was conducted i...

Effect of Thermocycling on Color Stability, Fracture Resistance, and Shear Bond Strength of CAD-on Restorations (Lithium Disilicate and Polymer-Infiltrated Ceramic Network) Fabricated on Zirconia Copings

Abstract The goal of the current in vitro investigation was to assess how artificial aging via thermocycling affected color stability, fracture resistance, and shear bond strength of CAD-on restorations made on zirconia copings veneered with polymer-infiltrated ceramic network (P...

Dietary acid load is associated with quality of life in overweight and obese adult in Iranian women: a cross sectional study

Epidemiologic investigations have shown that dietary acid load (DAL) is associated with some limited quality of life (QoL) markers; however, according to the documents available so far, the association of this dietary pattern with QoL among overweight and obese women is not clear...

Family-related Factors Associated With Readmission Among Children and Adolescents With Psychiatric Disorders

Background: Psychiatric readmission among children and adolescents is a major concern in mental health services and is influenced by clinical, familial, and demographic factors. However, the contribution of family-related variables remains insufficiently understood, particularly...

From oncogenesis to approval: the lentiviral gene therapy revolution in Wiskott–Aldrich syndrome

Wiskott–Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by pathogenic variants in the WAS gene, resulting in absent or dysfunctional WAS protein (WASp) and a clinical triad of eczema, recurrent infections, and micro-thrombocytopenia. Allogeneic hematopoietic...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Nano-enabled therapeutics for oral candida infections: a scoping review

Oral candidiasis remains a clinically relevant infection, particularly in drug-resistant strains of Candida . In recent years, nano-enabled therapeutics have been explored as potential alternatives to overcome the limitations of antifungal therapy. The present study aims to ident...

Challenges of parliamentary engagement in health policymaking in Iran: a qualitative study using Gaventa’s power cube framework

Parliaments play an important role in health governance through legislation, budgeting and oversight. However, their practical influence on health policy decisions remains poorly understood in systems where executive institutions and expert actors dominate policy processes. In Ir...

Outcomes of endoscopic sinus surgery (ESS) on sino-orbital osteomas: ophthalmic manifestations and visual outcomes from a 12-year multicenter experience and literature review

Osteomas are the most common benign craniofacial bone tumors that may extend into the orbital cavity. While the majority of them remain asymptomatic, orbital involvement can lead to clinically significant ophthalmologic manifestations. Although endoscopic sinus surgery (ESS) has...

Adiponectin-enriched liver-derived ECM attenuates fibrogenic features of activated hepatic stellate cells in a multicellular 3D model

Abstract Background Adiponectin (ADPN), an adipocytokine expressed in multiple tissues including the liver by quiescent hepatic stellate cells (HSCs) has recognized antifibrotic properties. However, most studies rely on simplified 2D systems that fail to capture the liver microen...

Crafting the DNA of smart hospitals: decoding standards and indicators through a scoping review

The significant global spread of smart hospitals emphasizes the need for clear and well-defined criteria and standards to effectively guide their design, implementation, evaluation, and management. This scoping review aimed to clarify the requirements for smart hospitals by exami...