Sungkyunkwan University

Survival impact of repeated endobiliary radiofrequency ablation in patients undergoing durvalumab plus gemcitabine and cisplatin for extrahepatic cholangiocarcinoma (BRAVE trial): study protocol for an international multicenter randomized controlled trial

Extrahepatic cholangiocarcinoma (eCCA) often presents with unresectable disease and obstructive jaundice. Systemic therapy with gemcitabine–cisplatin plus durvalumab (GCD) is an international standard; however, the median overall survival (OS) remains about 1 year. Endobiliary ra...

Antimony-contact MoS2 FET gas sensors for reinforcement-learning–driven hazard perception at room temperature

Two-dimensional van der Waals semiconductors promise low-power chemical perception at room temperature, yet contact-limited on-currents and slow recovery impede closed-loop decision making in hazardous environments. Here we propose antimony (Sb)-contact two-dimensional (2D) monol...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Season of sampling and the interpretation of serum homocysteine results: a within-person analysis of 268,877 health-screening examinations

OBJECTIVES: Serum total homocysteine (tHcy) is interpreted against fixed reference intervals and a decision limit. Whether the month of blood collection is a material source of variation, and whether it reflects the seasonal cycle of 25-hydroxyvitamin D [25(OH)D], is unresolved b...

Coupling Atomic Confinement With CO 2 Pressure for Selective and Stable CO 2 Electroreduction

ABSTRACT Electrochemical reduction of CO 2 (CO 2 RR) offers a promising route to convert waste carbon into valuable chemical feedstocks while mitigating greenhouse emissions. However, achieving high activity and selectivity in CO 2 RR remains challenging due to the low solubility...

A Simple and Scalable Approach to High-Resolution Breathable Nanomesh Electrodes for Skin-Attachable Bioelectronics

Abstract Skin-attachable nanomesh electrodes with breathability and biocompatibility are promising for next-generation wearable healthcare systems. However, they face challenges to achieve reliable high-resolution micropatterning. Here, we propose a simple approach to fabricate b...

Surface Ligand‐Mediated Carrier Balance for Stable Inverted Red InP Quantum Dot Light‐Emitting Diodes

ABSTRACT Indium phosphide (InP)‐based quantum dots (QDs) are cadmium (Cd)‐free emitters for display applications, but their operational stability is limited by surface defects and imbalanced carrier injection. Here, we introduce a [2‐(9H‐carbazol‐9‐yl)ethyl]phosphonic acid (2PACz...

Quantum Dot-Induced Kinetic Bottleneck in Singlet Exciton Relaxation of Conjugated Polymer Aggregates

Abstract We designed hybrid aggregate model systems with cascade energy alignment from conjugated polymers (CPs) to quantum dots (QDs) to investigate the effects of QDs on CP singlet (S1) excitons. Radiative recombination of S1 excitons occurs within 1 ps in the chlorinated CP/QD...

Does a Multi-Location CT Scan Provide a Survival Benefit as Surveillance after Curative-Intent Surgery in Early-Stage Non-Small Cell Lung Cancer?

Purpose: The NCCN guidelines recommend a chest computed tomography (CT) scan every 6 months for 2-3 years for patients with early-stage non-small cell lung cancer (NSCLC). This study aimed to evaluate whether multi-location CT scans offer a survival benefit. Materials and Methods...

Low-Temperature Plasma-Induced Oxygen-Vacancy Engineering Enables Orthorhombic-Phase Stabilization in Hf0.5Zr0.5O2 for 2D FeFETs toward Monolithic 3D Integration

Abstract The rapid growth in artificial intelligence and large-scale data processing has driven the urgent demand for energy-efficient electronic devices. Ferroelectric materials, especially hafnium zirconium oxide (Hf0.5Zr0.5O2, HZO), have emerged as promising candidates due to...

A compact, wireless fluorimeter system for continuous, real-time monitoring of tissue perfusion via in vivo fluorescence signals

In vivo fluorescence signals provide physiological and pathological insights for the interpretation of biological states associated with anatomical abnormalities or disease. Conventional methods for measuring fluorescence signals rely on bulky, costly instrumentation for imaging...

Revealing the Role of Ion Transport Properties through Ion-Exchange Membranes for Aqueous Zinc-Ion Battery

Abstract The separator material is a critical component that governs the cycling performance of aqueous zinc-ion batteries (AZIBs); however, how its ion transport properties dictate specific electrochemical behaviors remains poorly understood. Here, we investigated the relationsh...

Optimizing the Hinge Length of Chimeric Antigen Receptor with a DdFP-Based Immunological Synapse Biosensor

Abstract Chimeric antigen receptor (CAR)-T cell therapy has emerged as a transformative cancer immunotherapy, employing genetic engineering to express CARs in patient T cells. CARs are composed of a single-chain variable fragment (scFv), hinge, transmembrane, and intracellular si...

Interface-driven boost in the performance and stability of protonic ceramic electrochemical cells

Abstract Interfacial resistance remains a key challenge in developing high-performance and durable protonic ceramic electrochemical cells (PCECs), especially at low temperatures. Here, we present a systematic interface engineering strategy that quantitatively correlates interfaci...

Anatomical patterns and sequence of distant metastasis in myxoid liposarcoma: a Korean single-center retrospective cohort study

Myxoid liposarcoma (MLS) is a distinct soft tissue sarcoma subtype with a predilection for extrapulmonary metastasis. Cohort data describing the metastatic pattern in Korean patients are limited, and the within-patient temporal sequence of pulmonary and extrapulmonary metastasis...

Wide‐Bandgap Carbon Dots for Ultraviolet Photodetection: Structural Origins and Design Rules

ABSTRACT Tunable ultraviolet (UV) selectivity in solution‐processable photodetectors remains difficult because absorption, carrier transport, and interfacial extraction are tightly coupled. Carbon dots (CDs) offer broad structural and chemical tunability, yet their structure–stat...

Machine learning–driven decoding of maternal immune signatures in repeated pregnancy loss

Repeated pregnancy loss (RPL) is a multifactorial condition in which the underlying immunological mechanisms, particularly the disruption of maternal-fetal tolerance, remain incompletely understood. Although immune tolerance is critical for pregnancy success, the specific immune...

Residential indoor air monitoring to assess long-term exposure to air pollution in susceptible populations for epidemiology: overview and early findings

While there has been accumulating evidence of the association between long-term exposure to air pollution and various health endpoints, most epidemiological studies relied on ambient air pollution which showed substantial deviation from indoor. This difference could lead to biase...

Medical conflicts and their effect on Korean liver-related publications: A 2019–2024 analysis

Background: Concerns have arisen about a potential decline in Korean liver-related research output in 2024, possibly attributable to recent and severe medical conflicts.We investigated whether liver-related publication rates in Korea, particularly in the capital versus non-capita...

Guidelines for Meta‐Analytic Structural Equation Modeling: Steps, Resources, and Illustrations

ABSTRACT The goal of science is to build incremental, structured, and reliable knowledge over time. Yet, many strands of marketing and related disciplines exhibit symptoms of cumulative stagnation, including lack of replicability and weak theoretical integration. Existing remedie...