Sungkyunkwan University

Clinical experience in the treatment and prognosis of seven cases of Cronkhite-Canada syndrome

Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary gastrointestinal polyposis syndrome. The rarity of CCS has led to a limited understanding of its optimal management and prognosis. We aimed to share our experience with 7 CCS patients, investigating the clinical characteris...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

Engineering a terephthalate-responsive PobR biosensor for discovering PET-degrading microbes via cell-to-cell communication

Abstract Background Poly(ethylene terephthalate) (PET) is one of the most widely used synthetic plastics, yet its environmental accumulation continues to outpace effective recycling. Although PET-degrading enzymes and microorganisms have been reported, discovery of new PET-degrad...

Bio‐Inspired Oligocellulose‐Regulated Ice‐Water Interfaces Enable Sustained Ion Transport in Frozen Aqueous Zinc Batteries

ABSTRACT While highly concentrated salts and organic components enhance the subzero performance of zinc batteries by improving electrolyte fluidity and conductivity, their high cost and environmental pollution negate the inherent sustainability and economy of aqueous electrolytes...

Discovery of Energy‐Localized Trap States via Opto‐Electrical Spectroscopy in UWBG Perovskite La:SrSnO 3 FETs

ABSTRACT Strontium stannate perovskite (SrSnO 3 ) is emerging as a promising material for next‐generation ultra‐wide bandgap (UWBG) semiconductors due to its high electron mobility and optical transparency. However, despite the critical importance of defect analysis to utilize La...

Progression from carbapenemase-producing Enterobacterales colonisation to subsequent clinical isolation in a Korean regional surveillance cohort: a retrospective cohort study

Carbapenemase-producing Enterobacterales (CPE) colonisation may progress to clinical infection. We aimed to determine the incidence of and risk factors for progression from CPE colonisation to clinical isolation in a regional surveillance cohort. From the 2024 mandatory CRE surve...

Danburstotug, an anti‐ PD ‐ L1 antibody, in relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma: The phase 2 DISTINKT study

Summary Relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma (R/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death‐ligand 1 (PD‐L1), was evaluated in adults with R/R ENKTL in a phase 2, open‐label study (NCT04414163). Danburstot...

Clinical Application of Circulating Tumor DNA in Surgically Treated Esophageal Squamous Cell Carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is associated with a high recurrence rate and is one of the most aggressive malignancies. Recurrence is mainly detected via imaging modalities; however, postoperative imaging surveillance has disadvantages, including reduced s...

Identification of a Pathogenic RECQL4 1.6-kb Deletion–Insertion in a Neonate with Atypical Skeletal Phenotype of Baller–Gerold Syndrome Using Rapid Whole-Genome Sequencing

Mi-Ae Jang, M.D., Ph.D., Ja-Hyun Jang, M.D., Ph.D., Jin Kyu Kim, M.D., Ph.D., Joonhong Park, M.D., Ph.D., Go Hun Seo, M.D., Ph.D., Misun Yang, M.D., Ph.D., Yun Sil Chang, M.D., Ph.D., and Hyun Ho Kim, M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2026.0102

ChatGPT for pulmonary rehabilitation in chronic obstructive pulmonary disease is clinically credible but challenging for patients to use

Although interest in applying large language models (LLMs) in healthcare is rapidly growing, their role in supporting pulmonary rehabilitation (PR) for patients with chronic obstructive pulmonary disease (COPD) has not been well established. The primary objective of this study wa...

A Dispersant‐Driven Carbon‐Binder Domains Homogeneity in High‐Energy‐Density Electrodes for Lithium‐Ion Batteries

Achieving high energy density in lithium-ion batteries (LIBs) requires electrodes with a high fraction of active materials. An extreme reduction of inactive components such as conductive additives and binders can limit electron transport and undermine electrode integrity, thereby...

Mitigating Contact‐Constricted Thermal Bottlenecks by Magnetically Programmable hBN Bridge Fillers in Al 2 O 3 /Epoxy Composites

ABSTRACT Thermally conductive polymer composites often suffer from limited heat transport due to contact constriction in spherical particulate networks. To address this challenge, we report a magnetically programmable bridge‐filler architecture that enhances thermal pathways in e...

Microfluidic Cytotongue system enables early, label-free detection of CAR-T–induced mechanical softening in tumor spheroids

Quantitative assessment of chimeric antigen receptor T (CAR-T) activity in solid tumors remains challenging, as immune engagement can induce early mechanical softening of tumor spheroids before overt cell death becomes detectable. To address this limitation, we developed Cytotong...

Electronic Structure Modulation of Ni 2 P Nanospheres via Interfacial Control With Lattice‐Expanded MoS 2 Nanosheets for Enhanced Hydrogen Evolution

ABSTRACT The development of cost‐effective and durable electrocatalysts is a prerequisite for scalable hydrogen production via water electrolysis. In this context, modulating the electronic structure of transition‐metal phosphide electrocatalysts via interfacial engineering with...

Comparative Clinical Outcomes of Various Colorectal Endoscopic Submucosal Dissection Techniques: A Systematic Review and Network Meta-Analysis

Background/Aims: Traction-assisted endoscopic submucosal dissection (T-ESD), hybrid ESD (H-ESD), pocket-creation method ESD (P-ESD), and underwater ESD (U-ESD) were introduced to overcome the limitations of conventional ESD (C-ESD). We conducted a systematic review and network me...

Real-world genomic landscape of FGFR2 amplifications and fusions in solid tumors: analysis of 4,953 patients using clinical-grade NGS

Fibroblast growth factor receptor 2 (FGFR2) alterations, including amplifications and fusions, are actionable oncogenic drivers in multiple cancers, but their prevalence and genomic features are not well defined. Between October 2019 and October 2024 at Samsung Medical Center, 4,...

Evaluating Immunotherapy Outcomes in Elderly Patients with Extensive-Stage Small-Cell Lung Cancer (KCSG LU23-15)

PurposeChemoimmunotherapy has improved outcomes in extensive-stage small-cell lung cancer (ES-SCLC), but its benefit in older adults remains uncertain because this population is underrepresented in clinical trials.We evaluated the real-world efficacy of first-line atezolizumab pl...

Codon Design Online (CoDOn): a comprehensive web application of synthetic gene design with multi-criteria and multi-parameters for heterologous expression

Codon optimization is a routine yet high-impact step in de novo gene design for heterologous expression and serves as an important tool in synthetic biology. Protein expression output depends on multiple sequence-level determinants, such as global codon-usage, codon-pair context,...

Arming the archipelago: explaining A2/AD divergence in the South China Sea

How do secondary powers develop anti-access/area denial (A2/AD) capabilities when facing asymmetric threats? This article explains variation in Southeast Asian maritime defense strategies through a novel framework that distinguishes between anti-access (A2) and area denial (AD) b...