Sungkyunkwan University

Exercise-Induced Activation of IGF-1/mTOR Signaling and Hippocampal BDNF/PGC-1α Expression Reverses Age-Related Motor Decline

Purpose: Aging is associated with a progressive decline in skeletal muscle function and motor coordination, contributing to reduced mobility and quality of life. While exercise is a well-established intervention to counteract age-related deterioration, the underlying molecular me...

Dimethylacetamide-Associated Liver Injury in Workers: Clinical Patterns of Latency, Selective Occurrence, and Implications for Occupational Surveillance

OBJECTIVES: N,N-Dimethylacetamide (DMAc) is a widely used industrial solvent and recognized occupational hepatotoxicant. Human evidence, however, appears inconsistent: clinically oriented reports describe overt liver injury in selected workers, whereas large epidemiologic studies...

Colchicine Use and Risk of Cancer in Patients with Gout: A Nationwide Cohort Study

Preclinical studies suggested that colchicine possesses anti-mitotic and anti-inflammatory properties that can inhibit tumor cell proliferation and metastasis across various cancer models.However, real-world evidence on its potential anticancer effect remains limited.To evaluate...

Clinical utility of endorectal balloons in prostate cancer external beam radiotherapy: a systematic review and meta-analysis

Purpose: This study aimed to systematically evaluate the clinical utility of endorectal balloons (ERB) for motion management and organ-at-risk sparing in prostate cancer patients receiving external beam radiotherapy (EBRT) or stereotactic body radiotherapy (SBRT). Materials and M...

Development and Validation of a Novel Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Method for Serum 3-Epi-25-Hydroxyvitamin D 3 , 25-Hydroxyvitamin D 3 , and 25-Hydroxyvitamin D 2

Background: The epimeric form of 25-hydroxyvitamin D3 (3-epi-25-hydroxyvitamin D3, 3-epi-25-OH-D3) can interfere with the accurate measurement of total vitamin D. Therefore, reliable quantification of epimeric metabolites is important for improving measurement accuracy.Here, we d...

Comparative Diagnostic Performance of Atherogenic Indices and the Fatty Liver Index for Metabolic Dysfunction-Associated Fatty Liver Disease in a Korean Population

Background: Lipid metabolism abnormalities are a major risk factor for metabolic dysfunction-associated fatty liver disease (MAFLD) and cardiovascular disease.The atherogenic combined index (ACI) has been proposed as a novel predictor of coronary artery disease.We compared the di...

Chemical Constituents from Suaeda glauca and Their Protective Effects against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes

As part of our ongoing efforts to discover biologically active compounds from natural sources, we conducted a phytochemical investigation of Suaeda glauca, a halophytic plant widely distributed throughout Asia.Phytochemical investigation of the water extract of S. glauca led to t...

Distribution of VerifyNow Aspirin and P2Y12 Reaction Units in Adults Undergoing Preoperative Evaluation: A Single-Institution Retrospective Study

Background: VerifyNow Aspirin and P2Y12 assays (Werfen, Spain) measure residual platelet reactivity and may complement preoperative bleeding-risk assessment, but baseline values of aspirin reaction units (ARU) and P2Y12 reaction units (PRU) in individuals without antiplatelet exp...

Factors Affecting Palliative Care Needs Among Individuals With Head and Neck, Lung and Oesophageal Cancers Undergoing Radiotherapy

ABSTRACT Aim(s) To identify the palliative care needs of individuals with head and neck, lung and oesophageal cancers undergoing radiotherapy and explore the factors associated with these needs. Design This cross‐sectional descriptive study involved a survey. Methods Data were co...

Unveiling the Structural Advantages in PTFE‐Based Dry‐Processed Electrodes for Sulfide‐Based All‐Solid‐State Batteries via 3D Microstructure‐Resolved Analysis

ABSTRACT All‐solid‐state batteries (ASSBs) employing sulfide‐based solid electrolytes (SEs) are promising candidates for next‐generation lithium‐ion batteries owing to their high energy density and safety. Their electrochemical performance is strongly influenced by the electrode...

Report of 21 unrecorded bacterial species in Korea belonging to the phylum Actinobacteria, discovered during the survey in 2020

Ham, You Ju, Jeong, Ji Won, Im, Wan-Taek, Kim, Won-Yong, Yoon, Jeong-Hun, Kim, Myung Kyum, Seong, Chi Nam, Kim, Seung Bum (2022): Report of 21 unrecorded bacterial species in Korea belonging to the phylum Actinobacteria, discovered during the survey in 2020. Journal of Species Re...

Uncertainty quantification and parameter optimization of a plasma etching process using a heteroscedastic Gaussian process

This study presents an uncertainty-aware framework for the reliability-based robust design optimization (RBRDO) of plasma etching processes in semiconductor manufacturing. The framework is demonstrated using experimental measurements of the remaining thickness collected at nine w...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Ligand-Mediated Control of Zn x Se y Intermediates for Defect-Free ZnSe Heteroepitaxy on Quantum Dots

Abstract ZnSe is a cornerstone shell material for enhancing the efficiency and stability of quantum dots (QDs). However, the chemical mechanisms governing detrimental zinc vacancy (VZn) formation remain unclear, limiting the predictive synthesis of high-quality heterostructures....

Multidentate Coordination Enables Coupled Bulk Solvation and Interfacial Regulation for Stable Zinc Metal Anodes

ABSTRACT Aqueous Zn metal batteries are fundamentally constrained by the coupled instability of Zn 2+ solvation chemistry and interfacial reactions, which induces parasitic side reactions and non‐uniform Zn deposition. Here, we report a multidentate‐coordination electrolyte strat...

Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial

Evorpacept blocks the CD47–signal regulatory protein α interaction, enhancing antibody-dependent cellular phagocytosis. In the phase 2 portion of ASPEN-06 (a multicenter, open-label, randomized phase 2/3 study), 127 patients with pretreated, human epidermal growth factor receptor...

2D materials with rational design: Advancing electro- and photocatalytic CO2 reduction

CO 2 conversion is central to closing the anthropogenic carbon cycle. However, practical CO 2 RR remains limited by slow molecular activation, competing hydrogen evolution, and dynamic catalyst evolution under operating conditions. Two-dimensional (2D) materials are well suited t...

Classification of real plastic waste using machine learning-assisted laser-induced breakdown spectroscopy

Plastic type classification using laser-induced breakdown spectroscopy (LIBS) was evaluated using actual waste samples under non-optimized experimental conditions designed to approximate laser-sample variability encountered in industrial operation. The study addresses challenges...

BetaDAPR: An AI-based Expert Support System for Art Therapists with Qualitative and Quantitative Assistance

Sketch-based drawing assessments are valuable for understanding cognitive and psychological states but rely on therapists’ expertise, making them labor-intensive. While a few automated methods have been proposed, their capability is limited to supporting quantitative analysis, wh...

Endpoint genotyping of A2063G and A2064G mutations in Mycoplasma pneumoniae

Abstract Macrolide resistance in Mycoplasma pneumoniae is primarily associated with point mutations in domain V of the 23S rRNA gene, most commonly A2063G and A2064G. Rapid detection of these mutations is important for appropriate antimicrobial therapy. In this study, we develope...